Study reinforces drug's potential to treat hypertrophic cardiomyopathy
(Washington State University) WSU research sheds new light on a molecule that may be used to treat heart conditions that can lead to stroke, heart attack and other forms of heart disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 27, 2020 Category: International Medicine & Public Health Source Type: news
Oct 23 2020 This Week in Cardiology Oct 23 2020 This Week in Cardiology
COVID, tocilizumab, hypertrophic cardiomyopathy, cerebral microbleeds, and surrogate endpoints are the topics discussed by John Mandrola, MD, in this week ’ s podcasttheheart.org on Medscape (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 23, 2020 Category: Consumer Health News Tags: Cardiology Commentary Source Type: news
What Causes Hypertrophic Cardiomyopathy?
Title: What Causes Hypertrophic Cardiomyopathy?Category: Diseases and ConditionsCreated: 10/21/2020 12:00:00 AMLast Editorial Review: 10/21/2020 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - October 21, 2020 Category: Cardiology Source Type: news
Surgery Still Best Option in Obstructive HCM Surgery Still Best Option in Obstructive HCM
Promising results for a novel drug should not push surgical options aside for patients with obstructive hypertrophic cardiomyopathy, argue two surgeons.theheart.org on Medscape (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - October 15, 2020 Category: Cardiology Tags: Cardiology Commentary Source Type: news
Cell Therapy for Anthracycline Cardiomyopathy Safe, Feasible Cell Therapy for Anthracycline Cardiomyopathy Safe, Feasible
In a small phase 1 study, administration of allogeneic bone marrow-derived mesenchymal stromal cells was safe and feasible in patients with anthracycline-induced cardiomyopathy heart failure.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 2, 2020 Category: Consumer Health News Tags: Cardiology News Source Type: news
Cardiovascular adverse events associated with hydroxychloroquine and chloroquine: A comprehensive pharmacovigilance analysis of preCOVID19 reports
This analysis of the FAERS database found use of hydroxychloroquine and chloroquine was associated with a higher reporting rate of major CV adverse events, including cardiomyopathy (reporting OR 29.0), QT prolongation (4.5), cardiac arrhythmias (2.2) and heart failure (2.2). (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 24, 2020 Category: Consumer Health News Source Type: news
COVID-19: Analysis reveals heart-related side effects of hydroxychloroquine, chloroquine
In the analysis of real-world data from the Food and Drug Administration Adverse Events Reporting System, a global database of post-marketing safety reports, hydroxychloroquine and chloroquine were associated with higher rates of various cardiovascular problems, including life-threatening heart rhythm events, heart failure, and damage to the heart muscle itself (termed cardiomyopathy). (Source: The Economic Times)
Source: The Economic Times - September 22, 2020 Category: Consumer Health News Source Type: news
Fighting cardiovascular disease with acne drug
(European Molecular Biology Laboratory) Researchers from the European Molecular Biology Laboratory (EMBL) in Heidelberg and Stanford University have found the cause of dilated cardiomyopathy - a leading cause of heart failure - and identified a potential treatment for it: a drug already used to treat acne. The study was published on 8 September in Cell Reports. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 8, 2020 Category: International Medicine & Public Health Source Type: news
14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban
The cardiac membrane protein phospholamban (PLN) is targeted by protein kinase A (PKA) at Ser16 and by Ca2+/calmodulin-dependent protein kinase II (CaMKII) at Thr17. β-Adrenergic stimulation and PKA-dependent phosphorylation of Ser16 acutely stimulate the sarcoplasmic reticulum calcium pump (SERCA) by relieving its inhibition by PLN. CaMKII-dependent phosphorylation may lead to longer-lasting SERCA stimulation and may sustain maladaptive Ca2+ handling. Here, we demonstrated that phosphorylation at either Ser16 or Thr17 converted PLN into a target for the phosphoadaptor protein 14-3-3 with different affinities. 14-3-3 ...
Source: Signal Transduction Knowledge Environment - August 31, 2020 Category: Science Authors: Menzel, J., Kownatzki-Danger, D., Tokar, S., Ballone, A., Unthan-Fechner, K., Kilisch, M., Lenz, C., Urlaub, H., Mori, M., Ottmann, C., Shattock, M. J., Lehnart, S. E., Schwappach, B. Tags: STKE Research Articles Source Type: news
Study finds asymptomatic Chagas patients are at a high risk for cardiac disease
(University of Colorado Anschutz Medical Campus) People living with Chagas disease without symptoms or signs of cardiac injury are at high risk of developing cardiomyopathy, a progressive heart disease, and the risk more than doubled among patients with acute infections, according to a new study from the University of Colorado School of Medicine at the Anschutz Medical Campus. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - August 31, 2020 Category: Infectious Diseases Source Type: news
Preparticipation CV Screening: Who Gets the Red Card? Preparticipation CV Screening: Who Gets the Red Card?
Which cardiac conditions are disqualifying for kids who play sports? From hypertrophic cardiomyopathy to heart transplant, Mayo Clinic ' s Jonathan Johnson and Bernard Gersh have answers that may surprise you.Mayo Clinic (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - August 12, 2020 Category: Orthopaedics Tags: Cardiology Commentary Source Type: news
What Are Common Fatty Acid Oxidation Metabolic Disorders?
Discussion
All cells and particularly their mitochondria need an energy source. Glucose is one of the most common ones, but also fatty acids, lactate, pyruvate, ketones, and amino acids.
Fatty acids are formed with a carboxylic acid with a long aliphatic carbon chain usually with even numbers of carbon atoms (usually 4-28 most commonly).
Most are unbranched and in foods are usually found in the form of esters.
Fatty acids are important energy sources for the heart (50-70%) but also skeletal muscle where resting muscle uses both glucose and fatty acids. During fasting or increased stress fatty acids become a major source o...
Source: PediatricEducation.org - July 27, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
UCalgary research study finds MRI effective in predicting major cardiac events
(University of Calgary) An international study led by Dr. James White, a clinician and researcher at the University of Calgary finds magnetic resonance imaging can be used to predict major cardiac events for people diagnosed dilated cardiomyopathy. White's study confirms about 40 per cent of patients with DCM have scarring patterns on their heart muscle which can be seen with MRI. These patterns are associated with higher risk of future heart failure admissions, life-threatening heart rhythms and death. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 15, 2020 Category: International Medicine & Public Health Source Type: news
Can COVID-19 Promote Takotsubo Syndrome? Perhaps Not Directly Can COVID-19 Promote Takotsubo Syndrome? Perhaps Not Directly
The prevalence of stress cardiomyopathy, perhaps underappreciated as part of the pandemic ' s toll, seemed to turn sharply upward in patients presenting with ACS in March and April.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - July 13, 2020 Category: Cardiology Tags: Cardiology News Source Type: news
Incidence of Takotsubo Cardiomyopathy Up During COVID-19
FRIDAY, July 10, 2020 -- The incidence of Takotsubo cardiomyopathy has increased during the COVID-19 pandemic, according to a study published online July 9 in JAMA Network Open.
Ahmad Jabri, M.D., from Cleveland Clinic Akron General, and colleagues... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 10, 2020 Category: Pharmaceuticals Source Type: news
