Could statins ease deadly heart condition in rare neuromuscular disease?
(University of Pennsylvania School of Medicine) Decreased HDL and ApoA-l levels in the general population are associated with an increased risk of death from cardiomyopathy and heart failure. Researchers found the FA patients had serum ApoA-I levels lower than healthy control subjects. In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol-lowering drug increased a precursor of HDL (high-density lipoprotein), the " good cholesterol. " (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 17, 2018 Category: International Medicine & Public Health Source Type: news

High-Intensity Exercise Harmful in Arrhythmogenic Cardiomyopathy
FRIDAY, April 6, 2018 -- High-intensity exercise in an independent marker for ventricular arrhythmia (VA) in arrhythmogenic cardiomyopathy (AC), according to a study published online March 28 in JACC: Clinical Electrophysiology. Øyvind H. Lie,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 6, 2018 Category: Pharmaceuticals Source Type: news

Thrombolysis Deniers; Stroke Visor; Genetic Cardiomyopathy Drug
(MedPage Today) -- Recent developments of interest in cardiovascular medicine (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - April 2, 2018 Category: Cardiology Source Type: news

Methamphetamine Abuse Exacts Heavy Toll on the Heart Methamphetamine Abuse Exacts Heavy Toll on the Heart
A large case series sheds light on pulmonary arterial hypertension and dilated cardiomyopathy associated with methamphetamine abuse.Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - March 27, 2018 Category: Pathology Tags: Cardiology News Source Type: news

A Diagnostic Dilemma: Sometimes You ’ ll Never Know
Patient Presentation A 9-year-old male came to clinic with a 1 month history of painful joint swelling. One month ago he started having right ankle pain that was intermittent but consistent. One day ago his right wrist, right ankle and bilateral knees had some swelling but no erythema or warmth. He says that he has pain in them when he moves but not when he is resting and he denies any joint stiffness or gelling. He also had 1-2 days of multiple red skin lesions on his extremities and trunk, not overlying the affected joints. The skin lesions do not come and go and do not itch. They are mainly discrete circular lesions wi...
Source: PediatricEducation.org - March 19, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Chinese Medicine prescription found to improve heart function in those with dilated cardiomyopathy
(Natural News) The efficacy of Chinese versus western medicine has been a subject of debate for years. Traditional Chinese Medicine (TCM) banks on plant roots, fruits and herbs to cure illnesses. Western medicine, on other hand, consists of lab-synthesized chemical drugs. A recent study focused on the effect of TCM, using Yiqi Yangyin (a mixture of  various... (Source: NaturalNews.com)
Source: NaturalNews.com - March 10, 2018 Category: Consumer Health News Source Type: news

Genetic Testing for Cardiomyopathy Less Useful for Minorities
(MedPage Today) -- Dearth of data from non-white groups may reduce conclusive testing (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - February 28, 2018 Category: Cardiology Source Type: news

Gender, Other Factors Tip Meth Users Toward PAH or Cardiomyopathy
(MedPage Today) -- Mechanism by which methamphetamine affects heart still poorly understood (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - February 26, 2018 Category: Psychiatry Source Type: news

FDA Expands Impella Pump Indications in High-Risk PCI, Shock FDA Expands Impella Pump Indications in High-Risk PCI, Shock
The catheter-delivered temporary ventricular support pumps are now indicated for high-risk PCI regardless of LV function, and for shock secondary to cardiomyopathy, Abiomed announced.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 14, 2018 Category: Consumer Health News Tags: Cardiology News Alert Source Type: news

Abiomed wins expanded Impella FDA nod for elective, urgent high-risk PCI
Abiomed (NSDQ:ABMD) said today it won expanded FDA premarket approval for its Impella 2.5 and Impella CP heart pumps, now cleared for use during elective and urgent high risk percutaneous coronary intervention procedures. With the expansion, the Impella heart pump is cleared for use with patients with severe coronary artery disease, complex anatomy and a number of co-morbidities with or without depressed ejection fractions, the Danvers, Mass.-based company said. “This expanded FDA approval with moderately reduced ejection fraction validates our real-world experience using hemodynamic support in patients turned d...
Source: Mass Device - February 14, 2018 Category: Medical Devices Authors: Fink Densford Tags: Cardiac Assist Devices Cardiovascular Catheters Food & Drug Administration (FDA) Regulatory/Compliance Abiomed Source Type: news

FDA OKs Impella Heart Pump for Cardiomyopathy with Shock
(MedPage Today) -- Percutaneous devices expand beyond post-MI or procedural shock (Source: MedPage Today Nephrology)
Source: MedPage Today Nephrology - February 13, 2018 Category: Urology & Nephrology Source Type: news

Abiomed Receives Approval for Expanded FDA Indication for Cardiomyopathy with Cardiogenic Shock
DANVERS, Mass., Feb. 13, 2018 -- (Healthcare Sales & Marketing Network) -- Abiomed, Inc. (NASDAQ:ABMD), a leading provider of breakthrough heart support and recovery technologies, announced today that it has received an expanded U.S. Food and Drug Administ... Devices, Cardiology, FDA Abiomed, Impella, ventricular support, Cardiomyopathy, Cardiogenic Shock (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 13, 2018 Category: Pharmaceuticals Source Type: news

Abiomed touts expanded Impella heart pump indication, launches Women ’s Initiative
Abiomed (NSDQ:ABMD) said today it won expanded FDA premarket approval for its Impella 2.5, Impella CP, Impella 5.0 and Impella LD heart pumps, now cleared to provide treatment for heart failure associated with cardiomyopathy leading to cardiogenic shock, including peripartum and postpartum cardiomyopathy. The approval follows a previous FDA indication the Danvers, Mass.-based company won in April 2016 that cleared the device for treating acute myocardial infarction cardiogenic shock and post-cardiotomy cardiogenic shock. Abiomed touts its Impella heart pumps as the only percutaneous temporary ventricular support ...
Source: Mass Device - February 13, 2018 Category: Medical Devices Authors: Fink Densford Tags: Cardiac Assist Devices Cardiovascular Catheters Food & Drug Administration (FDA) Regulatory/Compliance Abiomed Source Type: news

FDA OKs Heart Pump for Cardiomyopathy with Shock
(MedPage Today) -- Percutaneous devices expand beyond post-MI or procedural shock (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - February 13, 2018 Category: Cardiology Source Type: news

ECG Challenge: Cardiomyopathy and an Irregular Pulse ECG Challenge: Cardiomyopathy and an Irregular Pulse
A patient with dilated cardiomyopathy presents with an irregular pulse. What does his ECG show?Medscape Cardiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 12, 2018 Category: Consumer Health News Tags: Cardiology Clinical Case Source Type: news

From the heart: The tale of a three-time transplant recipient
Playing youth hockey and Little League in the spring of 1988, I started to become easily fatigued. I became very weak and could no longer run around. By May, a visit to my pediatrician resulted in a trip to the Boston Children’s Hospital Cardiology Clinic on Fegan 6 and the first of many cardiac catheterizations I would receive in my life. The results of that first procedure were shared in my corner room across from the nurses’ station on 6 East (the cardiac step-down at the time): I would need a heart transplant for cardiomyopathy. It was Friday the 13th. I was 10 years old. Tim, before he ...
Source: Thrive, Children's Hospital Boston - February 7, 2018 Category: Pediatrics Authors: Tim Gallagher Tags: Our Patients’ Stories cardiac catheterization cardiomyopathy heart transplant Heart transplant program kidney transplant Pediatric Transplant Center (PTC) Source Type: news

SCD in Nonischemic Cardiomyopathy: Assessing Risk SCD in Nonischemic Cardiomyopathy: Assessing Risk
The authors suggest improvements to risk stratification among patients with nonischemic causes of cardioymopathy, focusing on the importance of etiology and identification of myocardial scarring.Journal of Cardiovascular Electrophysiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 6, 2018 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Takotsubo cardiomyopathy associated with work-place bullying - Malik H, Kangaharan N, Agahari I.
BACKGROUND: Takotsubo cardiomyopathy (TC) is a condition of transient left ventricular dysfunction precipitated by acute physical or emotional stress. The pathogenesis of TC is not well understood, but it is known to predominantly affect postmenopausal wom... (Source: SafetyLit)
Source: SafetyLit - January 22, 2018 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

MyoKardia Announces Appointment of Cynthia Ladd as General Counsel
SOUTH SAN FRANCISCO, Calif., Jan. 19, 2018 -- (Healthcare Sales & Marketing Network) -- MyoKardia, Inc. (Nasdaq:MYOK), a clinical-stage biopharmaceutical company pioneering a precision medicine approach for the treatment of heritable cardiovascular disease... Biopharmaceuticals, Cardiology, Personnel MyoKardia, cardiomyopathy, mavacamten (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - January 19, 2018 Category: Pharmaceuticals Source Type: news

Jim Lynskey has been fitted with a battery-operated heart
Jim Lynskey, from Redditch, Worcestershire, has an enlarged heart, known as dilated cardiomyopathy, after he and his twin sister, Grace, caught viral meningitis at just two weeks old. (Source: the Mail online | Health)
Source: the Mail online | Health - January 10, 2018 Category: Consumer Health News Source Type: news

Cardiomyopathy and Anaesthesia Cardiomyopathy and Anaesthesia
Learn about the different classifications of cardiomyopathy and their impact on perioperative management in this review.BJA Education (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 28, 2017 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Array BioPharma spins off cardiovascular myopathy drug research into new subisidiary
Boulder drug development company Array BioPharma has spun off its research into a treatment for a rare degenerative heart disease into a separate company. Array BioPharma (Nasdaq: ARRAY), in a filing to the U.S. Securities& Exchange Commission on Chistmas Eve, revealed that it had contributed intellectual property, inventory, equipment, clinical trial data and other material about its experimental cardiomyopathy drug to a subsidiary it ’s calling Yarra Therapeutics. The oral drug, known only… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - December 27, 2017 Category: American Health Authors: Greg Avery Source Type: news

Array BioPharma spins off cardiovascular myopathy drug research into new subisidiary
Boulder drug development company Array BioPharma has spun off its research into a treatment for a rare degenerative heart disease into a separate company. Array BioPharma (Nasdaq: ARRAY), in a filing to the U.S. Securities& Exchange Commission on Chistmas Eve, revealed that it had contributed intellectual property, inventory, equipment, clinical trial data and other material about its experimental cardiomyopathy drug to a subsidiary it ’s calling Yarra Therapeutics. The oral drug, known only… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - December 27, 2017 Category: Biotechnology Authors: Greg Avery Source Type: news

A different kind of heart attack: New research finds a broken heart permanently weakens the organ in a similar way
(Natural News) Researchers discover that severe emotional distress can damage the heart physically like a heart attack. At least 3,000 adults in the U.K. suffer from Takotsubo cardiomyopathy, colloquially termed as the “broken heart syndrome,” each year. It is caused by bereavement and severe emotional distress, which stuns and weakens the heart. This causes the... (Source: NaturalNews.com)
Source: NaturalNews.com - December 14, 2017 Category: Consumer Health News Source Type: news

Nigeria:Heart Failure - the Leading Cause of Death in New Mothers From Northern Nigeria?
[Vanguard] Peripartum cardiomyopathy (a type of heart failure that occurs during the last month of pregnancy or up to five months after delivery in young women) was one of the issues discussed at the just concluded Heart Failure awareness event, supported by Novartis on the 24th of November, 2017. Consultant cardiologists from all over Nigeria and several representatives from media houses in the country were present to discuss heart failure, risk factors and its impact on the lives of patients and the economy. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 12, 2017 Category: African Health Source Type: news

CHOP researchers highlight advances in pediatric heart disease at 2017 AHA scientific sessions
(Children's Hospital of Philadelphia) Physician-researchers from the Cardiac Center at Children's Hospital of Philadelphia (CHOP) recently presented new findings on pediatric cardiovascular disease at the American Heart Association's Scientific Sessions 2017 in Anaheim, Calif. Among many abstracts presented were research on racial disparities in bystander CPR methods in children with sudden cardiac arrest, and findings that children with hypertrophic cardiomyopathy may be at risk for sudden cardiac death. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 28, 2017 Category: International Medicine & Public Health Source Type: news

When Heart Disease Runs in the Family
Treatment TermsCardiomyopathy Overview Anne Goodes knew her heart beat faster than normal, but it wasn ’t until her local cardiologist detected a heart murmur that she discovered she was at risk for sudden cardiac death. At Duke, she learned the cause was hypertrophic cardiomyopathy, a common heart condition that can run in the family. Goodes soon discovered her children may need to take precaution s as well. Hero Image2017_anne_heart_596.jpg Preview Image Content Blocks Header Learning to Live with Hypertrophic Cardiomyopathy ContentHypertrophic cardiomyopathy affects the cells that make up the heart muscle,...
Source: dukehealth.org: Duke Health News - November 27, 2017 Category: Consumer Health News Authors: dg62 at duke.edu Source Type: news

Cell Therapy Shows'Hope' for Duchenne Cardiomyopathy Cell Therapy Shows'Hope' for Duchenne Cardiomyopathy
In HOPE-Duchenne, patients with Duchenne cardiomyopathy who received an infusion of cardiosphere-derived cells plus usual care had a 7% reduction in myocardial scars 1 year later.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 22, 2017 Category: Consumer Health News Tags: Cardiology News Source Type: news

Male Triathletes May Be Harming Their Hearts
Source: HealthDay Related MedlinePlus Pages: Cardiomyopathy, Men's Health, Sports Injuries (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - November 21, 2017 Category: Consumer Health News Source Type: news

MRI discovers heart damage among male triathletes
Using late gadolinium-enhanced MRI scans, German researchers found myocardial...Read more on AuntMinnie.comRelated Reading: Some cardiac MRI findings predict future heart events Stress cardiac MR matches 320-row CCTA results Study shows feasibility of cardiac PET/MRI -- with caveats Cardiac MR tops ECG in finding hidden myocardial infarctions Late MRI enhancement predicts death risk in hypertrophic cardiomyopathy (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 21, 2017 Category: Radiology Source Type: news

Practice nurses urged to learn cardiomyopathy symptoms
Practice nurses and GPs are being urged to talk to patients about their family history of heart disease by a charity, in the wake of latest survey results. (Source: Nursing Times)
Source: Nursing Times - November 9, 2017 Category: Nursing Source Type: news

Peripartum Cardiomyopathy More Severe for Black Women Peripartum Cardiomyopathy More Severe for Black Women
African American women with peripartum cardiomyopathy present with worse symptoms, are less likely to recover, and when they do, take twice as long compared with other groups, a new study shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 13, 2017 Category: Consumer Health News Tags: Cardiology News Source Type: news

Black Women Face Double the Risk of Pregnancy-Related Heart Failure
FRIDAY, Oct. 13, 2017 -- Black American women are twice as likely as women in other racial/ethnic groups to develop a form of pregnancy-related heart failure, a new study finds. Peripartum cardiomyopathy (PPCM) is a potentially life-threatening... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 13, 2017 Category: General Medicine Source Type: news

Pregnancy-related heart failure strikes black women twice as often as those of other races
(University of Pennsylvania School of Medicine) African American women were found to be twice as likely to be diagnosed with peripartum cardiomyopathy as compared to women of Caucasian, Hispanic/Latina, Asian, and other ethnic backgrounds, according to a new study -- the largest of its kind -- published today in JAMA Cardiology by researchers from the Perelman school of Medicine at the University of Pennsylvania. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 11, 2017 Category: International Medicine & Public Health Source Type: news

Fruit fly muscles with a hypertrophic cardiomyopathy mutation don't relax properly
(Johns Hopkins Medicine) Using fruit flies, Johns Hopkins researchers have figured out why a particular inherited human heart condition that is almost always due to genetic mutations causes the heart to enlarge, thicken and fail. They found that one such mutation interferes with heart muscle's ability to relax after contracting, and prevents the heart from fully filling with blood and pumping it out. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 9, 2017 Category: International Medicine & Public Health Source Type: news

Scorpion-related cardiomyopathy and acute pulmonary edema in a child who is stung by Leiurus abdullahbayrami - Dokur M, Do ğan M, Yagmur EA.
Venom of Leiurus abdullahbayrami (Scorpiones: Buthidae) is an extremely toxic one and it stimulates voltage-gated sodium and potassium channels. In case of a stung by this scorpion; excessive catecholamine release occur and it impairs left ventricle contra... (Source: SafetyLit)
Source: SafetyLit - October 5, 2017 Category: International Medicine & Public Health Tags: Non-Human Animals and Insects Source Type: news

BioVentrix launches pivotal Revivent TC trial in US
BioVentrix said today it enrolled the 1st US patient in a pivotal clinical trial of its Revivent TC transcatheter ventricular enhancement system designed to treat patients with heart failure symptoms related to cardiomyopathy. The Revivent system is designed to eliminate the need for cardiopulmonary bypass or incisions in the heart by enabling the placement of small titanium anchors along the heart’s outer surface and along 1 of the inside walls, according to the San Ramon, Calif.-based company. The 1st US patient was enrolled at the UPMC Heart and Vascular Institute by Dr. Catalin Toma and Dr. Christopher Sciortino,...
Source: Mass Device - October 4, 2017 Category: Medical Devices Authors: Fink Densford Tags: Cardiovascular Catheters Clinical Trials BioVentrix Source Type: news

BioVentrix announces the 1st Revivent TC(TM) TransCatheter Ventricular Enhancement procedure for Ischemic Cardiomyopathy treatment at the University Heart Center Zurich in Switzerland
SAN RAMON, Calif., and ZURICH, Sept. 18, 2017 -- (Healthcare Sales & Marketing Network) -- BioVentrix, Inc. a pioneer of technologies and procedures for less invasive treatment of heart failure (HF), today announced the first clinical use of its closed-ch... Devices, Interventional, Cardiology BioVentrix, Revivent TC, TransCatheter, Ventricular Enhancement (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - September 18, 2017 Category: Pharmaceuticals Source Type: news

TTR Cardiomyopathy Easily Detected By Biceps Bunching
(MedPage Today) -- Biceps tendon rupture may be a clue to HF cause (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - September 12, 2017 Category: Cardiology Source Type: news

NaviGate touts 1st 52mm transcatheter tricuspid valve procedure
NaviGate Cardiac Structures touted this week that its Gate catheter-guided tricuspid atrioventricular valved stent was implanted six weeks ago into a patient’s transplanted heart. The patient’s transplanted heart was failing due to severe tricuspid valve insufficiency. The successful implantation at the Policlinico of the University of Padua, Italy, is the first European-based patient treated with the company’s tricuspid replacement heart valve. Three hours after the procedure, the patient was showing improved renal function, NaviGate reported. Two months after the intervention, the 67-year-old male patie...
Source: Mass Device - September 1, 2017 Category: Medical Devices Authors: Sarah Faulkner Tags: Cardiac Implants Cardiovascular NaviGate Cardiac Structures Inc Source Type: news

Preventing sudden death in hypertrophic cardiomyopathy: ESC guidelines (HCM-EVIDENCE)
(European Society of Cardiology) A large study conducted across North America, Europe, the Middle East and Asia has validated the ESC recommendations for predicting and preventing sudden cardiac death (SCD) in patients with hypertrophic cardiomyopathy (HCM). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 29, 2017 Category: International Medicine & Public Health Source Type: news

BioVentrix wins FDA IDE nod, launches Revivent TC trial
BioVentrix said today it received FDA investigational device exemption approval and launched a safety and efficacy trial of its Revivent TC transcatheter ventricular enhancement system designed to treat patients suffering from ischemic cardiomyopathy. The Revivent system is designed to eliminate the need for cardiopulmonary bypass or incisions in the heart by enabling the placement of small titanium anchors along the heart’s outer surface and along one of the inside walls, according to the San Ramon, Calif.-based company. The San Ramon, Calif.-based company said it enrolled the 1st patient in the Alive trial, wi...
Source: Mass Device - August 21, 2017 Category: Medical Devices Authors: Fink Densford Tags: Cardiovascular Clinical Trials Food & Drug Administration (FDA) BioVentrix Source Type: news

BioVentrix Announces First Patient Enrolled in IDE Study of the Revivent TC(TM) TransCatheter Ventricular Enhancement Treatment for Ischemic Cardiomyopathy
SAN RAMON, Calif. and CAMBRIDGE, England, Aug. 21, 2017 -- (Healthcare Sales & Marketing Network) -- BioVentrix, Inc. a pioneer of technologies and procedures for less invasive treatment of heart failure (HF), today announced enrollment of the first patie... Devices, Cardiology BioVentrix, Revivent TC, TransCatheter Ventricular Enhancement (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - August 21, 2017 Category: Pharmaceuticals Source Type: news

After 10 months, Alnylam still can't explain patient trial deaths
More than 10 months after disclosing that patients who received one of its experimental drugs in a late-stage trial had died at a far higher rate than those on placebo, Cambridge-based Alnylam Pharmaceuticals still cannot conclusively explain what went wrong. Alnylam (Nasdaq: ALNY) on Wednesday released the results of its investigation into the deaths of older patients with heart problems who took revusiran, a potential treatment for a deadly inherited disease called hATTR cardiomyopathy. In October,… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - August 10, 2017 Category: American Health Authors: Max Stendahl Source Type: news

After 10 months, Alnylam still can't explain patient trial deaths
More than 10 months after disclosing that patients who received one of its experimental drugs in a late-stage trial had died at a far higher rate than those on placebo, Cambridge-based Alnylam Pharmaceuticals still cannot conclusively explain what went wrong. Alnylam (Nasdaq: ALNY) on Wednesday released the results of its investigation into the deaths of older patients with heart problems who took revusiran, a potential treatment for a deadly inherited disease called hATTR cardiomyopathy. In October,… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - August 10, 2017 Category: Biotechnology Authors: Max Stendahl Source Type: news

'Exercise pill' could potentially help people with heart failure
Conclusion The protein hCT1 caused heart muscles to grow in a more healthy way in rodents with heart failure. When treatment stopped, the heart went back to its original condition – something that does not happen when the heart grows in a dysfunctional way. There is currently no cure for heart failure and treatment is only available for keeping symptoms under control. Therefore, this very promising early-stage research with potential for developing a drug for people with heart failure, has huge implications. However, it is important to remember that as this is experimental laboratory research, there are man...
Source: NHS News Feed - August 9, 2017 Category: Consumer Health News Tags: Heart/lungs Source Type: news

MyoKardia ’s Phase II trial for oHCM drug meets endpoints
MyoKardia has reported positive top-line results from the first cohort of its Phase II PIONEER-HCM clinical trial of mavacamten in patients with symptomatic, obstructive hypertrophic cardiomyopathy (oHCM). (Source: Drug Development Technology)
Source: Drug Development Technology - August 8, 2017 Category: Pharmaceuticals Source Type: news

UIowa study examines altered gene expression in heart failure
(University of Iowa Health Care) Heart tissue from patients with heart failure exhibits increased levels of Cdk8 protein. Mimicking this increased Cdk8 expression in transgenic mouse hearts alters gene expression in a way that promotes heart failure. When University of Iowa researchers examined the mouse heart cells before a decrease in heart function was detectable, they found over 3,400 genes already expressed with a profile similar to that of human heart muscle cells with dilated cardiomyopathy and heart failure. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 4, 2017 Category: International Medicine & Public Health Source Type: news

Researchers successfully edit 1st human embryo with CRISPR
Scientists have successfully edited genes in a human embryo, correcting a disease-causing mutation to prevent the defect from being inherited. The groundbreaking process, covered in a paper published yesterday in Nature, was confirmed last week by the Oregon Health and Science University, which collaborated with the Salk Institute and Korea’s Institute for Basic Science on the task. To edit the genetic mutation, in this case for hypertrophic cardiomyopathy, researchers used a technique known as CRISPR-Cas9. The CRISPR-Cas9 technique operates as a sort of ‘molecular scissors’ which can trim away unwanted p...
Source: Mass Device - August 3, 2017 Category: Medical Devices Authors: Fink Densford Tags: Biotech Research & Development Source Type: news

Gene editing used to repair diseased genes in embryos
Conclusion Currently, genetically-inherited conditions like hypertrophic cardiomyopathy cannot be cured, only managed to reduce the risk of sudden cardiac death. For couples where one partner carries the mutated gene, the only option to avoid passing it onto their children is pre-implantation genetic diagnosis. This involves using IVF to create embryos, then testing a cell of the embryo to see whether it carries the healthy or mutated version of the gene. Embryos with healthy versions of the gene are then selected for implantation in the womb. Problems arise if too few or none of the embryos have the correct version of the...
Source: NHS News Feed - August 3, 2017 Category: Consumer Health News Tags: Genetics/stem cells Source Type: news