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Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT
The precursor homocysteine is metabolized either through the methionine cycle to produce methionine or through the transsulfuration pathway to synthesize cysteine. Alternatively, cysteine can be obtained through uptake of its oxidized form, cystine. Many cancer cells exhibit methionine dependency such that their proliferation is impaired in growth media in which methionine is replaced by homocysteine. We showed that oncogenic PIK3CA and decreased expression of SLC7A11, a gene that encodes a cystine transporter also known as xCT, correlated with increased methionine dependency in breast cancer cells. Oncogenic PIK3CA was su...
Source: Signal Transduction Knowledge Environment - December 19, 2017 Category: Science Authors: Lien, E. C., Ghisolfi, L., Geck, R. C., Asara, J. M., Toker, A. Tags: STKE Research Articles Source Type: news

Medical tyranny: Woman who rejected breast cancer diagnosis may still be forced undergo surgery without her consent
(Natural News) When a doctor suggests an operation that you don’t feel is necessary, you have the right to decide not to move forward with it – right? If you happen to have any sort of mental illness, it’s something that doctors could use to say you’re not in your right mind to make such... (Source: NaturalNews.com)
Source: NaturalNews.com - December 18, 2017 Category: Consumer Health News Source Type: news

ctDNA Testing'Could Help Prevent Breast Cancer Relapses'ctDNA Testing'Could Help Prevent Breast Cancer Relapses '
The threat of breast cancer recurrence could soon be averted by offering women additional treatment in advance of their relapse, thanks to the latest circulating tumor DNA assays, says a UK expert.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 18, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

UCLA senior delivers digital health monitoring to fight disease in Cameroon
As Vikash Singh looks forward to 2018 he is also looking forward to witnessing his education in action. Specifically how his background in medical research, artificial intelligence and machine learning — along with a $5,000UCLA Global Citizens Fellowship award and some innovative thinking — may potentially help save lives in Cameroon.Doctors at the HSPC Polyclinic in Kumba, a city located in the country ’s southwest region, will soon begin uploading patient information to a software application designed by Singh and a team of student programmers through Project DataReach, a company Singh launched in 2015 ...
Source: UCLA Newsroom: Health Sciences - December 18, 2017 Category: Universities & Medical Training Source Type: news

GnRH Analogue Use Preserves Fertility During Chemotherapy GnRH Analogue Use Preserves Fertility During Chemotherapy
Meta-analysis confirms that the use of a GnRH analogue during chemotherapy helps preserve ovarian function and fertility in young women undergoing treatment for early breast cancer.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 18, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Breast Pain Uncommon Symptom of Breast Cancer Breast Pain Uncommon Symptom of Breast Cancer
Breast pain is not often a symptom of breast cancer regardless of age, and mostly women need to be reassured that breast pain is both common and benign.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 18, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Simplified Surgery Reduces Lymphedema Risk After ALND Simplified Surgery Reduces Lymphedema Risk After ALND
Simplified surgical technique greatly reduces the risk for postoperative lymphedema following axillary lymph node dissection and breast cancer surgery.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 18, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

' Powerful Trend': Chemo Use for Breast Cancer Drops'Powerful Trend': Chemo Use for Breast Cancer Drops
Between 2013 and 2015, the use of chemotherapy in early-stage breast cancer in the United States sharply decreased, according to a study.Medscape Medical News (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - December 18, 2017 Category: Surgery Tags: Hematology-Oncology News Source Type: news

Researchers repurpose immune-activating cytokine to fight breast cancer
The most lethal form of breast cancer could have a new treatment option, according to new research out of the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine. In the Proceedings of the National Academy of Sciences, researchers showed triple-negative breast cancer cells are highly vulnerable to interferon-β - a potent antimicrobial that also activates the immune system. The new study shows interferon-β impairs breast cancer cells' ability to migrate and form tumors. (Source: World Pharma News)
Source: World Pharma News - December 18, 2017 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

A New PARP Drug For Breast Cancer? I'm Thrilled!
The paradigm for using chemo first to treat advanced breast cancer may change, as we gain experience with these new drugs. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - December 18, 2017 Category: Pharmaceuticals Authors: Elaine Schattner, Contributor Tags: NYSE:PFE NYSE:AZN NASDAQ:TSRO NASDAQ:CLVS Source Type: news

Why I'm Thrilled About A New PARP Drug For Breast Cancer
The paradigm for using chemo first to treat advanced breast cancer may change, as we gain experience with these new drugs. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - December 18, 2017 Category: Pharmaceuticals Authors: Elaine Schattner, Contributor Tags: NYSE:PFE NYSE:AZN NASDAQ:TSRO NASDAQ:CLVS Source Type: news

Lapatinib With Foretinib in HER2+ Metastatic Breast Cancer Lapatinib With Foretinib in HER2+ Metastatic Breast Cancer
Early research finds limited activity with the combination of lapatinib and foretinib for advanced HER2+ breast cancer.Breast Cancer Research (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 18, 2017 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Germline Genetics and Decision Making in Breast Cancer Germline Genetics and Decision Making in Breast Cancer
Patients with breast cancer often undergo genetic testing without seeing a genetic counselor. Does this affect their treatment decisions?Journal of Clinical Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 18, 2017 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Mutational signatures may ID pts with Br Ca most likely to benefit from platinum-based chemo
(American Association for Cancer Research) The presence in advanced breast cancer of mutational signatures characteristic of homologous recombination deficiency (HRD) was associated with improved clinical outcomes to treatment with platinum-based chemotherapy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 18, 2017 Category: International Medicine & Public Health Source Type: news

Researchers repurpose immune-activating cytokine to fight breast cancer
(Case Western Reserve University) The most lethal form of breast cancer could have a new treatment option, according to new research out of the Case Comprehensive Cancer Center. In PNAS, researchers showed triple-negative breast cancer cells are highly vulnerable to interferon-β -- a potent antimicrobial that also activates the immune system. The new study shows interferon-β impairs breast cancer cells' ability to migrate and form tumors. The study also suggests interferon-β treatment could improve outcomes for certain breast cancer patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 18, 2017 Category: Cancer & Oncology Source Type: news

NHS to fund new specialised treatments
Some 3,000 patients with HIV, genetic conditions and skin disorders will benefit Related items fromOnMedica Work needed to boost GPs ’ knowledge of cancer drug Ovarian cancer drug may help stall breast cancer NHS launches mass HIV prevention trials World AIDS Day: The fight against HIV Stevens-Johnson syndrome and toxic epidermal necrolysis (Source: OnMedica Latest News)
Source: OnMedica Latest News - December 18, 2017 Category: UK Health Source Type: news

JACQUIE BELTRAO on her tamoxifen living hell
Tamoixifen might be a lifesaver for breast cancer patients, but it's irritating side effects, such as late night hot flushes, are absolutely awful, writes Sky News' JACQUIE BELTRAO. (Source: the Mail online | Health)
Source: the Mail online | Health - December 17, 2017 Category: Consumer Health News Source Type: news

New Cancer Drug Shows Promise Against Wide Range of Tumors
(Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - December 16, 2017 Category: Cancer & Oncology Source Type: news

Women don't know about breast cancer treatment options
Many women don't feel completely informed about their surgical options for...Read more on AuntMinnie.comRelated Reading: Contrast US helps assess breast cancer treatment response Breast cancer treatment varies in cost-effectiveness DBT reduces breast surgery re-excision rates Clinical trials to shed new light on preoperative breast MRI Imaging tool could reduce repeat breast cancer surgeries (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - December 15, 2017 Category: Radiology Source Type: news

Medical News Today: Breast cancer: These gene variations may shorten young women's survival
New research finds that young women with early-onset breast cancer possess variations in a specific gene that might affect their survival. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 15, 2017 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Exercise Proven, but Underused, for Breast Cancer Fatigue Exercise Proven, but Underused, for Breast Cancer Fatigue
Despite the fact that studies have consistently shown that exercise reduces breast cancer fatigue, many physicians do not discuss exercise programs with their breast cancer patients.Medscape Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 15, 2017 Category: Consumer Health News Tags: Hematology-Oncology Article Source Type: news

New Potential Drug Therapy for AI-Associated Arthralgia New Potential Drug Therapy for AI-Associated Arthralgia
The anti-depressant duloxetine effectively reduced musculoskeletal symptoms early in the course of treatment with aromatase inhibitors for early-stage breast cancer.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - December 15, 2017 Category: Cancer & Oncology Tags: Hematology-Oncology Viewpoint Source Type: news

Women overestimate breast cancer risk, prefer biopsy
Most women tend to overestimate their risk of breast cancer, according to research...Read more on AuntMinnie.comRelated Reading: At-risk women not receiving breast MRI scans Mammo recalls don't keep women from other tests Most women prefer annual breast cancer screening Women still value mammography's benefits over 'harms' Simple interventions reduce mammography recall rates (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - December 15, 2017 Category: Radiology Source Type: news

Aspirin, NSAIDs and Prospective Risk of HER2+ Breast Cancer Aspirin, NSAIDs and Prospective Risk of HER2+ Breast Cancer
Does aspirin or ibuprofen reduce risk of HER2+ breast cancer?Breast Cancer Research (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 15, 2017 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Many women report not feeling completely informed about breast cancer treatment options
(American College of Surgeons) Results from two separate studies in the Journal of the American College of Surgeons showed a decision aid tool may help mitigate the sense of urgency patients feel about making treatment decisions. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 15, 2017 Category: International Medicine & Public Health Source Type: news

Journalists can register now to attend the European Breast Cancer Conference (EBCC-11)
(ECCO-the European CanCer Organisation) Journalists can register now to attend the European Breast Cancer Conference (EBCC-11), which takes place in Barcelona, Spain, Wednesday 21 to Friday 23 March 2018. Registration for media is free. Europe's most exciting international cancer conference is the only one to involve all the major players in breast cancer. Scientists, clinicians, patient representatives and policy makers will discuss the latest scientific advances, and also the ethical, social, political, and practical issues associated with caring for patients with breast cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 15, 2017 Category: International Medicine & Public Health Source Type: news

New Technology Can Help Detect Breast Cancer In Some Women
BOSTON (CBS) – More than 40% of women in the United States have dense breasts which can make it hard to find small cancers on a mammogram, but researchers are testing a new technology that could help. It is a 3-dimensional ultrasound called SoftVue. During the exam, the patient lies on her stomach, and her breast is placed into a warm water bath. In two to four minutes, the machine creates a 3D image using sound waves. SoftVue exam (WBZ-TV) There is no radiation and no compression of the breast. While SoftVue probably would not replace a woman’s annual mammogram, it might be used in conjunction with mammography...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 14, 2017 Category: Consumer Health News Authors: Health – CBS Boston Tags: Breast Cancer Health Local News Syndicated Local Dr. Mallika Marshall HealthWatch Local TV Source Type: news

Light & #039;Em Up: S & amp;N & #039;s Device Images Bacteria in Wounds
Smith & Nephew has begun selling a handheld imaging device that can detect bacteria in hard-to-heal wounds and instantly measure wound surface area. MolecuLight i:X is already available in Canada, where its inventor stumbled across the idea for the device. Ralph DaCosta, MD, now a principal investigator at Princess Margaret Cancer Center in Toronto, was a PhD student researching fluorescent imaging of gastrointestinal cancer in 2007. The big, expensive device he was using didn’t produce any green images, which would have indicated cancer, but a red image that he couldn’t identify. DaCosta took a photo of t...
Source: MDDI - December 14, 2017 Category: Medical Devices Authors: Nancy Crotti Tags: Imaging Source Type: news

Many With Early Breast Cancer Are Skipping Chemo
Fewer women with early stage breast cancer are turning to chemotherapy to fight their disease, a new study finds. (Source: WebMD Health)
Source: WebMD Health - December 14, 2017 Category: Consumer Health News Source Type: news

Bristol mother-of-three receives a Christmas miracle
Heidi Loughlin, 35, from Bristol, said the world is her oyster after defying the death sentence imposed on her by doctors. She was diagnosed with a rare and aggressive breast cancer in 2015. (Source: the Mail online | Health)
Source: the Mail online | Health - December 14, 2017 Category: Consumer Health News Source Type: news

Mother-of-three, 35, receives a Christmas miracle
Heidi Loughlin, 35, from Bristol, said the world is her oyster after defying the death sentence imposed on her by doctors. She was diagnosed with a rare and aggressive breast cancer in 2015. (Source: the Mail online | Health)
Source: the Mail online | Health - December 14, 2017 Category: Consumer Health News Source Type: news

Many With Early Breast Cancer Are Skipping Chemo
Title: Many With Early Breast Cancer Are Skipping ChemoCategory: Health NewsCreated: 12/13/2017 12:00:00 AMLast Editorial Review: 12/14/2017 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - December 14, 2017 Category: Cancer & Oncology Source Type: news

Scientists pinpoint gene to blame for poorer survival rate in early-onset breast cancer patients
(University of Southampton) A new study led by scientists at the University of Southampton has found that inherited variation in a particular gene may be to blame for the lower survival rate of patients diagnosed with early-onset breast cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 14, 2017 Category: Cancer & Oncology Source Type: news

Could ultrasound scans detect breast cancer?
A new type of ultrasound scan is being tested to see if it's as effective as mammograms in detecting breast cancer, especially in women with dense breast tissue. CBS News' Danielle Nottingham reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - December 13, 2017 Category: Consumer Health News Source Type: news

Many with Early Breast Cancer Are Skipping Chemo
Source: HealthDay Related MedlinePlus Pages: Breast Cancer, Cancer Chemotherapy (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - December 13, 2017 Category: Consumer Health News Source Type: news

Researchers test ultrasound to detect breast cancer
If proven to be effective, the new type of scans could eventually be used in addition to annual mammograms (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - December 13, 2017 Category: Consumer Health News Source Type: news

Many With Early Breast Cancer Are Skipping Chemo
WEDNESDAY, Dec. 13, 2017 -- Fewer women with early stage breast cancer are turning to chemotherapy to fight their disease, a new study finds. " For patients with early stage breast cancer, we've seen a significant decline in chemotherapy use over... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 13, 2017 Category: General Medicine Source Type: news

Hormonal Contraception and Risk for Breast Cancer: Many Caveats Hormonal Contraception and Risk for Breast Cancer: Many Caveats
This large-scale study is an important contribution to the literature, notes Dr JoAnn Manson, but should it change practice?Medscape Ob/Gyn (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 13, 2017 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Commentary Source Type: news

AI Could Help Detect Lymph Node Metastases
Some artificial intelligence computer programs outperformed pathologists in detecting lymph node metastases of breast cancer in a recent study. The findings appear in JAMA. Researchers... (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - December 13, 2017 Category: Primary Care Source Type: news

Everolimus With Trastuzumab and Paclitaxel for HER2+ MBC Everolimus With Trastuzumab and Paclitaxel for HER2+ MBC
Is the combination of everolimus, trastuzumab, and paclitaxel as safe in Asian patients as it is in the overall population?Breast Cancer Research (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 13, 2017 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Malignant mitochondria as a target
(Wiley) Killing malignant mitochondria is one of the most promising approaches in the development of new anticancer drugs. Scientists from the UK have now synthesized a copper-containing peptide that is readily taken up by mitochondria in breast cancer stem cells, where it effectively induces apoptosis. The study, which has been published in the journal Angewandte Chemie, also highlights the powerful therapeutic potential of the metallopeptides. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 13, 2017 Category: International Medicine & Public Health Source Type: news

Birth control can lower cancer risk as well
A recent study found that birth control was linked to an increased risk of breast cancer. But a doctor from Brigham& Women's Hospital explains why the benefits can outweigh the risks. (Source: the Mail online | Health)
Source: the Mail online | Health - December 12, 2017 Category: Consumer Health News Source Type: news

Will 'AI' Be Part of Your Health-Care Team?
One new study suggests artificial intelligence (AI) might someday detect breast cancer that has spread to the lymph nodes. (Source: WebMD Health)
Source: WebMD Health - December 12, 2017 Category: Consumer Health News Source Type: news

AI Ups Precision in Breast Cancer Pathology AI Ups Precision in Breast Cancer Pathology
In a challenge of diagnostic accuracy and precision in metastatic breast cancer, artificial intelligence (AI) outperformed pathologists at reviewing and interpreting whole-slide images.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 12, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Fewer women getting chemotherapy for early stage breast cancer
Fewer women are receiving chemotherapy for the treatment of early stage breast cancer. (Source: Health News - UPI.com)
Source: Health News - UPI.com - December 12, 2017 Category: Consumer Health News Source Type: news

Artificial intelligence shows promise for breast cancer metastases
Computer algorithms analyzing pathology slides can detect the spread of cancer...Read more on AuntMinnie.comRelated Reading: Video from RSNA 2017: How will AI change radiology? Breast AI algorithm could reduce unnecessary surgery by 30% How to develop deep-learning algorithms for radiology AI algorithm uses color to better detect breast cancer SIIM: Deep learning can help assess breast density (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - December 12, 2017 Category: Radiology Source Type: news

Study reveals breast cancer can return years after the "all clear" – Experts already pushing to keep women on prescriptions longer (no mention of lifestyle)
(Natural News) The findings of a new study out of England have blown yet another hole in the conventional cancer therapy myth, revealing that women who undergo typical procedures like chemotherapy and radiation for breast cancer often see the deadly disease return – in some cases up to 20 years after they were supposedly “cured.”... (Source: NaturalNews.com)
Source: NaturalNews.com - December 12, 2017 Category: Consumer Health News Source Type: news

Breast cancer risk once again linked to hormonal contraceptive pills
A study published in theNew England Journal of Medicine reports that the sustained use of birth control pills is associated with a small but significant risk of breast cancer.News Medical (Source: Society for Endocrinology)
Source: Society for Endocrinology - December 12, 2017 Category: Endocrinology Source Type: news

Has Your Doc Been Touched by Breast Cancer? It Could Influence Care
Title: Has Your Doc Been Touched by Breast Cancer? It Could Influence CareCategory: Health NewsCreated: 12/11/2017 12:00:00 AMLast Editorial Review: 12/12/2017 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - December 12, 2017 Category: Cancer & Oncology Source Type: news

AI algorithm matches radiologists in breast screening exams
How does an artificial intelligence (AI) algorithm compare to radiologists...Read more on AuntMinnie.comRelated Reading: Video from RSNA 2017: How will AI change radiology? Breast AI algorithm could reduce unnecessary surgery by 30% How to develop deep-learning algorithms for radiology AI algorithm uses color to better detect breast cancer SIIM: Deep learning can help assess breast density (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - December 12, 2017 Category: Radiology Source Type: news