Fight Aging! Newsletter, February 26th 2024
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition.
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Reviewing the Development of Senotherapeutics to Treat Aging
https://www.fightaging.org/archives/2024/02/reviewing-the-development-of-senotherapeutics-to-treat-aging/
Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells ...
Source: Fight Aging! - February 25, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
To What Degree is Alzheimer's Disease a Modern Phenomenon?
Here find an interesting commentary on what might be gleaned of the prevalence of Alzheimer's disease in antiquity from the body of ancient writings on the topic of aging, memory, and health. The consensus is that Alzheimer's disease is a creation of modernity, some combination of a longer life expectancy for a greater fraction of the population coupled with increased calorie intake and less active lives. Yet unlike type 2 diabetes, risk of Alzheimer's risk doesn't correlate well with the usual suspect lifestyle choices that raise the risk of age-related disease and lower life expectancy.
This line of thinking has l...
Source: Fight Aging! - February 19, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 5th 2023
In conclusion, higher BMR might reduce lifespan. The underlying pathways linking to major causes of death and relevant interventions warrant further investigation.
Betting Against Progress Turns Out Poorly, But Can Work in the Short Term in a Slow Field
https://www.fightaging.org/archives/2023/06/betting-against-progress-turns-out-poorly-but-can-work-in-the-short-term-in-a-slow-field/
Setting oneself up as a spokesperson for "we will not achieve this goal", as the fellow noted here is choosing to do, is a bet against technological progress. A glance at any few decade period in the past two hundred yea...
Source: Fight Aging! - June 4, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Long Term Hypoxia Slows Aging in an Accelerated Aging Mouse Model
Researchers here show that a mouse model of accelerated aging lives considerably longer when in a low-oxygen atmosphere for most of its life span. This is quite interesting, even given that large effect sizes in accelerated aging models should be taken with a grain of salt. It is most likely that any effect on normal mice would be smaller, and also likely that any form of life extension achieved through manipulation of stress responses, such as the response to hypoxia, will produce much smaller effects in long-lived mammals than in short-lived mammals.
As is always the case, recall that when we say "accelerated agin...
Source: Fight Aging! - June 2, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Mentoring Month: NIGMS-Funded Researchers Make Mentoring Meaningful
Mentoring is a vital part of training the next generation of scientists. Through a variety of programs ranging from the undergraduate to faculty levels, NIGMS fosters the training and the development of a strong and diverse biomedical research workforce.
To celebrate National Mentoring Month, we’re highlighting a few of the many NIGMS-funded researchers who emphasize being great mentors. Check out the snapshots of our interviews with these mentors to see what they think about mentoring and to access and read their full stories.
Dr. Julia Bohannon. Credit: Vanderbilt University Medical Center.
Scientist Studie...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 11, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education Profiles Research Roundup Training Source Type: blogs
Career Conversations: Q & A with Biomolecular Engineer Markita Landry
Dr. Markita Landry. Credit: Vilcek Foundation.
“I have a hard time envisioning a career more exciting than science. It’s really magical to see an experimental result and, for a moment, be the only person in the universe to know something about the world,” says Markita Landry, Ph.D., an associate professor of chemical and biomolecular engineering at the University of California, Berkeley. In an interview, Dr. Landry shares with us her scientific journey, research with nanoparticles, and interests outside of the lab.
Q: What sparked your interest in science?
A: I was indirectly exposed to science growing up bec...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 14, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Tools and Techniques Cool Tools/Techniques Profiles Source Type: blogs
No, Colombia Is Not Legalizing Cocaine. But It Should
Daniel RaisbeckThe American media ’s coverage of Colombia’s supposedly new drug policy has been odd. As I argue in my recent piece inForeign Policy, left ‐winger Gustavo Petro, who became president last August, has been offering the same old prohibitionist formulas despite claims to the contrary inThe New York Times,The Washington Post, and other traditional media outlets.Take, for instance, the Colombian government ’s claim that a change to regional drug policy is imminent because, as Petro ’s “drug czar” stated, this is“a rare moment in which many key governments in the region — including t...
Source: Cato-at-liberty - November 21, 2022 Category: American Health Authors: Daniel Raisbeck Source Type: blogs
Weekly Roundup – November 19, 2022
Welcome to our Healthcare IT Today Weekly Roundup. Each week, we’ll be providing a look back at the articles we posted and why they’re important to the healthcare IT community. We hope this gives you a chance to catch up on anything you may have missed during the week.
eClinicalWorks, the Cloud, and Medical Practice Expansion. John Lynn recently wrote about how eClinicalWorks has invested heavily in Microsoft Cloud Services. It’s a good strategic move for the EHR vendor, but it also benefits eCW customers, as John found out when he spoke to Bryant Stetz at Rothman Orthopaedic Institute and learned that hosted EHR...
Source: EMR and HIPAA - November 19, 2022 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Healthcare IT Today Weekly Roundup Source Type: blogs
Rapid Diagnosis: Vomiting Blood
The dispatcher reports that the patient is vomiting blood. Hemataemesis if you want to be technical about it. It could be a whole bunch of things right? … Well yes it could. Before you e-mail me to say that you can’t believe I missed Bolivian Hemorrhagic Fever, here’s one web site that lists 113 possibilities.
But if you want to play the numbers, it’s going to be one of four things. And if you want to play “stump your partner” you can narrow it down quite a bit based on your patients age and disposition.
There are four things that tend to cause a person to vomit blood. Before you click on the little ...
Source: The EMT Spot - November 14, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
MobilTEK Launches First International Telehealth Program
The following is a guest article by Sara Hendren, Global Telehealth Lead at MobilTeK by Care on Location.
MobilTEK, launched its first international telehealth program in the department of Chuquisaca Bolivia in March of 2022. Through a collaborative partnership with Alliance Bolivia, PROCOSI, and SEDES Chuquisaca, two MobilTEK telehealth exam kits were placed in the communities of Zudanez and El Villar through a pilot program that will study the acceptability, useability, and adaptability of telehealth technology in relation to the current flow of patient care and to address the distance gap between specialist and patien...
Source: EMR and HIPAA - November 11, 2022 Category: Information Technology Authors: Guest Author Tags: Ambulatory Health IT Company Healthcare IT Telemedicine and Remote Monitoring Alliance Bolivia Care on Location Chagas Disease Chuquisaca Bolivia El Villar MobilTEK MobilTEK Telehealth Kit PROCOSI Rural Communities Sara Hendren Source Type: blogs
Fight Aging! Newsletter, October 3rd 2022
In conclusion, based on the analysis of proteomics and transcriptome, we identified four SRMs that may affect aging and speculated their possible mechanisms, which provides a new target for preventing aging, especially skin aging.
A Popular Science Article on the State of Epigenetic Clocks
https://www.fightaging.org/archives/2022/09/a-popular-science-article-on-the-state-of-epigenetic-clocks/
This popular science article is a good view of the present state of development and use of epigenetic clocks, covering the issues as well as the promise. Epigenetic age can be measured, with many different clocks...
Source: Fight Aging! - October 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Prevention and Effective Treatment of Atherosclerosis Should Be a High Priority
Today's open access paper underscores the point that prevention and treatment of atherosclerosis should be a high priority in medical research, development, and practice. It is the single largest cause of death in our species, killing a quarter of humanity directly, and arguably another tenth indirectly. Atherosclerosis is the malfunction of macrophage cells responsible for clearing excess and altered cholesterol from blood vessel walls. The result is the accumulation of fatty lesions, and a tipping point in which the contents of the lesion overwhelm the macrophage cells attempting to remove it, thereafter continually addi...
Source: Fight Aging! - September 28, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Chile and Latin America ’s Disposable Constitutions
Ian V ásquezChile votes this Sunday on a proposed, new constitution. It is a far-left document that would undermine fundamental rights and impoverish the country. Chileans should reject it. My colleagues and I have discussed the Chilean success story under the current constitution, the political conditions that gave rise to a constitutional convention that began meeting last year, and the problems with the proposed basic charterhere,here,here,here, andhere.In light of Chile ’s referendum, I reprint below a rough translation of anarticle I published in Peru in 2019 about Latin America ’s sorry tradition of frequently r...
Source: Cato-at-liberty - September 3, 2022 Category: American Health Authors: Ian V ásquez Source Type: blogs
We ’re only able to mentally represent an exact number if we have a word for it
By Emma Young
Babies, monkeys and even bees have a basic “sense of number”. They can instantly perceive that there are one, two, three or four objects in a pile, without having to count them. They can also tell at a glance that a pile of 50 objects contains more than a pile of 20, say. But what explains the unique ability of older kids and adults to go far beyond this, and mentally represent quantities much bigger than four exactly? Some researchers argue that language must be key — that learning to count “one”, “two”, “three”, and on and on, enables this cognitive feat...
Source: BPS RESEARCH DIGEST - March 8, 2022 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Cognition Language Source Type: blogs
Case of the Week 662
This week ' s case is a stool specimen from a 52-year-old Bolivian farmer. He complains of intermittent right upper quadrant pain, and an abdominal CT showed edema and dilation of the bile ducts.Identification? (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - November 29, 2021 Category: Parasitology Source Type: blogs
