Delayed GI Symptoms and a Liver Transplant
A 16-year-old boy presented to an emergency department in rural Pennsylvania for nausea, vomiting, and diarrhea. He reported diffuse abdominal cramping that had started two hours earlier. Shortly prior to arrival, he had multiple episodes of nonbloody diarrhea and emesis. He had no significant past medical history, and was not currently taking any medications or supplements. Initially, the history he gave was limited due to a language barrier. His sister was also being evaluated for similar symptoms.The boy's vital signs were a heart rate of 130 bpm, a blood pressure of 100/50 mm Hg, a respiratory rate of 26 bpm, an oxy...
Source: The Tox Cave - November 30, 2020 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
A gastroenterologist ’s COVID musings from behind the mask
I was recently asked to see an 89-year-old woman who was gravely ill in the intensive care unit. She was admitted with cholangitis due to bile duct stones causing complete obstruction leading to septic shock. It is a life-threatening situation, especially in elderly patients. She needed an emergency endoscopic procedure: ERCP. By the way, one […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 14, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/sripathi%e2%80%8b-kethu" rel="tag" > Sripathi Kethu, MD < /a > < /span > Tags: Conditions COVID-19 coronavirus Gastroenterology Infectious Disease Source Type: blogs
Fight Aging! Newsletter, September 7th 2020
In conclusion, using a large cohort with rich health and DNA methylation data, we provide the first comparison of six major epigenetic measures of biological ageing with respect to their associations with leading causes of mortality and disease burden. DNAm GrimAge outperformed the other measures in its associations with disease data and associated clinical traits. This may suggest that predicting mortality, rather than age or homeostatic characteristics, may be more informative for common disease prediction. Thus, proteomic-based methods (as utilised by DNAm GrimAge) using large, physiologically diverse protein sets for p...
Source: Fight Aging! - September 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Update on Lygenesis: Functional Liver Organoids in the Lymph Nodes of Pigs
Lygenesis is the company founded to conduct the clinical development of research into the use of lymph nodes to support the growth and function of organoids. Lymph nodes are found in the lymphatic system, places where immune cells can coordinate with one another in order to produce an immune response. Mammals have more lymph nodes than they need, and so it is possible to insert small pieces of organ tissue into a few lymph nodes, transforming them into miniature organs, without harming the immune system. This can in principle work well for factory organs like the liver and thymus, which carry out functions that do not have...
Source: Fight Aging! - September 1, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 29th 2020
In conclusion, metabolomics is a promising approach for the assessment of biological age and appears complementary to established epigenetic clocks.
Sedentary Behavior Raises the Risk of Cancer Mortality
https://www.fightaging.org/archives/2020/06/sedentary-behavior-raises-the-risk-of-cancer-mortality/
Living a sedentary lifestyle is known to be harmful to long term health, raising the risk of age-related disease and mortality. Researchers here show that a sedentary life specifically increases cancer mortality, and does so independently of other factors. This is one of many, many reasons to maintain a r...
Source: Fight Aging! - June 28, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cyclic Peptides to Remodel the Gut Microbiome by Suppressing Growth of Harmful Bacteria
Research into the effects of the gut microbiome on health and aging is presently flourishing. Scientists are identifying meaningful changes in microbial populations that take place with age, as well as metabolites generated by gut microbes that favorably influence health, such as indoles, butyrate, propionate, and so forth. With advancing age, the balance of microbial populations shifts from beneficial to harmful. The production of beneficial metabolites decreases. Microbes invade gut tissue to produce a state of chronic inflammation that spreads to accelerate the onset and progression of age-related disease throughout the...
Source: Fight Aging! - June 23, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 15th 2020
In this study, we used markers to monitor the formation of SGs in Caenorhabditis elegans. We found that, in addition to acute heat stress, SG formation could also be triggered by dietary changes, such as starvation and dietary restriction (DR). We found that HSF-1 is required for the SG formation in response to acute heat shock and starvation but not DR, whereas the AMPK-eEF2K signaling is required for starvation and DR-induced SG formation but not heat shock. Moreover, our data suggest that this AMPK-eEF2K pathway-mediated SG formation is required for lifespan extension by DR, but dispensable for the longevity by reduced ...
Source: Fight Aging! - June 14, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rat Livers Decellularized, then Recellularized with Human Cells and Transplanted
A decellularized organ is one that has had the cells stripped out, such as via detergent solutions, leaving behind the extracellular matrix. Decellularization is a way to obtain a fully detailed organ scaffold, complete with chemical cues to guide the reconstruction of tissues when new cells are added, without having to build it from scratch. That task that is presently impossible, though some groups are making headway in the construction of scaffolds detailed enough for use in tissue engineering. Interestingly, decellularization allows the use of human cells in animal organs: this may be a viable path towards farming pigs...
Source: Fight Aging! - June 10, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A man in his sixties with chest pain
Written by Pendell MeyersA man in his sixties with no prior history of CAD presented with fluctuating central chest pain that started the night before presentation, then went away, then woke him up from sleep the morning of presentation. The pain was 10/10 on arrival, with SOB. Although he also had some nasal drip and sore throat, he had no cough or fevers (this occurred during peak COVID).Here is his triage ECG:What do you think?Normal P-waves would have upright morphology in the inferior leads (especially lead II) and usually biphasic (up-down) morphology in V1. These p-waves are negative in almost all leads except for a...
Source: Dr. Smith's ECG Blog - June 2, 2020 Category: Cardiology Authors: Pendell Source Type: blogs
Caroli's Disease : Radiology
Presentation30 year old patient presented to emergency with sepsis and cholangitis.RadiologyCT scan revealed multiple hypodense rounded areas and some of them showing the classical central dot sign: enhancing portal radicle within the dilated intrahepatic bile ducts. MRCP was done and it demonstrated continuity with the biliary tree. Diagnosis of Caroli's disease was made.Famous Radiology Blog http://www.sumerdoc.blogspot.com
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Source: Sumer's Radiology Site - April 20, 2020 Category: Radiology Authors: Sumer Sethi Source Type: blogs
OK, boomer: You ’re not the only one who needs testing for hepatitis C
It turns out that many more people than just boomers can benefit from testing for hepatitis C, a viral infection of the liver that often causes no symptoms. If you’re a member of the baby-boom generation (born between 1946 and 1964), your doctor may have already recommended the test. But those born before or after those years may not have known about the test unless they had a risk factor for hepatitis C, such as a history of intravenous drug use. A new guideline is changing this approach.
Why the different recommendations for baby boomers?
In 2012–2013, the CDC and the US Preventive Services Task Force (USPSTF) establ...
Source: Harvard Health Blog - March 31, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Digestive Disorders Health Infectious diseases Men's Health Sexual Conditions Women's Health Source Type: blogs
HNF4 α in the Effects of Intermittent Fasting on the Liver
Intermittent fasting strategies such as alternate day fasting are known to be beneficial to health in humans and both health and longevity in animal models. A portion of this outcome likely stems from some degree of reduction in overall calorie intake, but animal studies in which calorie intake is consistent between control and intermittent fasting groups demonstrate that benefits still arise even when calories are not reduced. Lengthy enough periods of hunger likely trigger the same cellular maintenance mechanisms as play a role in the metabolic response to calorie restriction when practiced without fasting. The biochemis...
Source: Fight Aging! - March 16, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Machine Keeps Livers Alive for a Week, Revives Injured Ones
A Swiss collaboration of clinical researchers from University Hospital Zurich, ETH Zurich, Wyss Zurich, and the University of Zurich has created a machine that can keep human livers alive for up to a week. For comparison, current methods of perfusion can keep livers going for about 24 hours.
Moreover, the same device can be used to rehabilitate injured livers so that they’re healthy enough to be used for transplants. The multi-parameter device is described in journal Nature Biotechnology, where the researchers detail how the device, a goal of the Liver4Life project of Wyss Zurich, can manage a liver outside a huma...
Source: Medgadget - January 14, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Surgery Source Type: blogs
Fight Aging! Newsletter, December 30th 2019
This study presents the effects of berberine (BBR) on the aging process resulting in a promising extension of lifespan in model organisms. BBR extended the replicative lifespan, improved the morphology, and boosted rejuvenation markers of replicative senescence in human fetal lung diploid fibroblasts. BBR also rescued senescent cells with late population doubling (PD). Furthermore, the senescence-associated β-galactosidase (SA-β-gal)-positive cell rates of late PD cells grown in the BBR-containing medium were ~72% lower than those of control cells, and its morphology resembled that of young cells. Mechanistically, BBR im...
Source: Fight Aging! - December 29, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
