What Happens to Medicine in Your Body?
Medicines administered orally, by inhaler, and intravenously enter the stomach, lungs, and veins, respectively. They’re absorbed, then circulate throughout the body in the blood, are processed by the liver, and excreted by the kidneys and intestines. Credit: NIGMS.
Have you ever wondered what happens inside your body when you take a medicine? An area of pharmacology called pharmacokinetics is the study of precisely that. Here, we follow a medicine as it enters the body, finds its therapeutic target (also called the active site), and then eventually leaves the body.
To begin, a person takes or is given a dose of medi...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - September 11, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Common questions Medicines Miniseries Source Type: blogs
Fight Aging! Newsletter, May 8th 2023
In conclusion, NAT mitigated age-associated cerebral injury in mice through gut-brain axis. The findings provide novel evidence for the effect of NAT on anti-aging, and highlight the potential application of NAT as an effective intervention against age-related diseases.
Retinal Cell Reprogramming Restores Vision in Non-Human Primate Study
https://www.fightaging.org/archives/2023/05/retinal-cell-reprogramming-restores-vision-in-non-human-primate-study/
Early applications of in vivo cellular reprogramming to medicine are cautiously focused on retinal regeneration. The eye is as close to an isolated system...
Source: Fight Aging! - May 7, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Neoagarotetraose Supplementation Improves Gut Microbiome to Extend Life in Mice
In conclusion, NAT mitigated age-associated cerebral injury in mice through gut-brain axis. The findings provide novel evidence for the effect of NAT on anti-aging, and highlight the potential application of NAT as an effective intervention against age-related diseases.
Link: https://doi.org/10.1016/j.jare.2023.04.014 (Source: Fight Aging!)
Source: Fight Aging! - May 1, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Quotations Missing from Bartlett ’s
David BoazOverat The Dispatch (ungatedhere) I have a critique of the latest edition ofBartlett ' s Familiar Quotations. As I say,Bartlett ' sis " the gold standard of quotations, the place anyone can go to confirm a quote and see the source. " But its editors " seem far more familiar with the words of liberal, leftist, and socialist sources than those of conservatives and libertarians. "Over the past 40 years, since the rise of Ronald Reagan, Margaret Thatcher, John Paul II, and even Deng Xiaoping, the world has seen a turn toward markets and economic freedom (albeit with a fall in 2020 during the pandemic lockdowns). But...
Source: Cato-at-liberty - March 6, 2023 Category: American Health Authors: David Boaz Source Type: blogs
Fight Aging! Newsletter, January 16th 2023
Conclusions
Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue
Assessment of Somatic Mosaicism as a Biomarker of Aging
The Gut Microbiome of Centenarians
https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/
The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Gut Microbiome of Centenarians
In this study, we combined metagenomic sequencing and large-scale in vitro culture to reveal the unique gut microbial structure of the world's longevity town - Jiaoling, China, centenarians, and people of different ages. Functional strains were isolated and screened in vitro, and the possible relationship between gut microbes and longevity was explored and validated in vivo, revealing associations of the gut microbiota with age and a number of clinical and metabolic parameters.
We uncovered age-specific gut microbiota characteristics, including a core set of seven microbial taxa enriched in centenarians and the gut ...
Source: Fight Aging! - January 9, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Basic Functions of Abdominal Organs
Most EMT level providers are square on the primary function of the stomach. We can name several things our liver is doing for us and we get the whole kidney concept as well. But when we start drifting beyond the basics, the conversation can turn fuzzy.
OK … It’s been a little while since I studied this. What was the spleen doing again? Something about the immune system right? Oh, the Pancreas that produces Insulin doesn’t it? Or was that the gallbladder?
Fear not. I put together a handy reference for you. Here’s a list of all those abdominal organs for your review. Now you can sort your large...
Source: The EMT Spot - November 7, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
Fight Aging! Newsletter, November 7th 2022
In conclusion, the national prevalence of dementia and MCI in 2016 found in this cross-sectional study was similar to that of other US-based studies.
Clearing Microglia Reverses Age-Related Disruption of Sleeping Patterns in Mice
https://www.fightaging.org/archives/2022/11/clearing-microglia-reverses-age-related-disruption-of-sleeping-patterns-in-mice/
Microglia are innate immune cells of the central nervous system. They are analogous to macrophages in the rest of the body, but undertake additional duties relating to the function of neurons and in brain tissue. Microglia become overly active and inflamm...
Source: Fight Aging! - November 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing Approaches to Treating Transthyretin Amyloidosis
Transthyretin amyloidosis may be a primary component of the present limit on human longevity. Transthyretin is one of the few proteins in the human body that can misfold in ways that encourage other molecules of the same protein to misfold in the same way, joining together form solid aggregates that disrupt cell and tissue function. This is particularly an issue in the cardiovascular system, and while it is presently thought that transthyretin amyloidosis only contributes to a minority of fatal cardiovascular disease in younger old age, autopsies of supercentenarians suggested that it is the major cause of death in the old...
Source: Fight Aging! - November 3, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 10th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 9, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Correlation Between a Worse Gut Microbiome and Aging of the Heart
The state of the gut microbiome may be as influential on health as exercise. The balance of microbial populations changes with age, in detrimental ways, for reasons that are not fully understood. The decline of the immune system, responsible for gardening the gut microbiome and defending intestinal tissue, may be one of the more important factors. With age, microbial populations producing beneficial metabolites decline in number, while populations contributing to chronic inflammation grow in number. There are interventions, such as fecal microbiota transplant, that can reverse these changes in a lasting way to improve heal...
Source: Fight Aging! - October 7, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, September 5th 2022
Conclusion
Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome.
The most interesting part of the data is perhaps the decline in microbial diversity, when considered against the gains elsewhere. Microbial dive...
Source: Fight Aging! - September 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Two Year Update on a Study of One with Flagellin Immunization to Adjust the Gut Microbiome
Conclusion
Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome.
The most interesting part of the data is perhaps the decline in microbial diversity, when considered against the gains elsewhere. Microbial dive...
Source: Fight Aging! - September 1, 2022 Category: Research Authors: Reason Tags: Self-Experimentation Source Type: blogs
Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols.
FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Role of Cellular Senescence in Liver Disease
Senescent cells are play a role in the onset and progression of near every age-related condition. Cells become senescent constantly throughout the body and throughout life, most because they have reached the Hayflick limit to replication. In youth, senescent cells are efficiently removed, either through programmed cell death or by the immune system. With age, the immune system declines in effectiveness. Senescent cells begin to linger and grow in number. These errant cells secrete a mix of pro-growth, pro-inflammation signals that, when present over the long term, disrupt cell and tissue function.
Today's open acce...
Source: Fight Aging! - January 20, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
