Identifying inhibitors of Trypanosoma cruzi nucleoside diphosphate kinase 1 as potential repurposed drugs for Chagas' disease
Biochem Pharmacol. 2023 Aug 25:115766. doi: 10.1016/j.bcp.2023.115766. Online ahead of print.ABSTRACTTrypanosoma cruzi is the causative agent of Chagas' disease, an endemic and neglected disease. The treatment is limited to only two drugs, benznidazole (BZL) and nifurtimox (NFX), introduced more than fifty years ago and no new advances have been made since then. Nucleoside diphosphate kinases (NDPK) are key metabolic enzymes which have gained interest as drug targets of pathogen organisms. Taking advantage of the computer-assisted drug repurposing approaches, in the present work we initiate a search of potential T. cruzi n...
Source: Biochemical Pharmacology - August 27, 2023 Category: Drugs & Pharmacology Authors: Facundo Galceran Fabio A Digirolamo Marcos Rengifo Chantal Reigada Melisa Saye Belen J Maciel Ivana G Estecho Andrea E Errasti Claudio A Pereira Mariana R Miranda Source Type: research
Identifying inhibitors of Trypanosoma cruzi nucleoside diphosphate kinase 1 as potential repurposed drugs for Chagas' disease
Biochem Pharmacol. 2023 Aug 25:115766. doi: 10.1016/j.bcp.2023.115766. Online ahead of print.ABSTRACTTrypanosoma cruzi is the causative agent of Chagas' disease, an endemic and neglected disease. The treatment is limited to only two drugs, benznidazole (BZL) and nifurtimox (NFX), introduced more than fifty years ago and no new advances have been made since then. Nucleoside diphosphate kinases (NDPK) are key metabolic enzymes which have gained interest as drug targets of pathogen organisms. Taking advantage of the computer-assisted drug repurposing approaches, in the present work we initiate a search of potential T. cruzi n...
Source: Biochemical Pharmacology - August 27, 2023 Category: Drugs & Pharmacology Authors: Facundo Galceran Fabio A Digirolamo Marcos Rengifo Chantal Reigada Melisa Saye Belen J Maciel Ivana G Estecho Andrea E Errasti Claudio A Pereira Mariana R Miranda Source Type: research
Identifying inhibitors of Trypanosoma cruzi nucleoside diphosphate kinase 1 as potential repurposed drugs for Chagas' disease
Biochem Pharmacol. 2023 Aug 25:115766. doi: 10.1016/j.bcp.2023.115766. Online ahead of print.ABSTRACTTrypanosoma cruzi is the causative agent of Chagas' disease, an endemic and neglected disease. The treatment is limited to only two drugs, benznidazole (BZL) and nifurtimox (NFX), introduced more than fifty years ago and no new advances have been made since then. Nucleoside diphosphate kinases (NDPK) are key metabolic enzymes which have gained interest as drug targets of pathogen organisms. Taking advantage of the computer-assisted drug repurposing approaches, in the present work we initiate a search of potential T. cruzi n...
Source: Biochemical Pharmacology - August 27, 2023 Category: Drugs & Pharmacology Authors: Facundo Galceran Fabio A Digirolamo Marcos Rengifo Chantal Reigada Melisa Saye Belen J Maciel Ivana G Estecho Andrea E Errasti Claudio A Pereira Mariana R Miranda Source Type: research
LB1773 Dutasteride in the treatment of frontal fibrosing alopecia: Systematic review and meta-analysis
Background: Frontal fibrosing alopecia (FFA) is a type of scarring alopecia characterized by fronto-temporo-parietal hairline recession which is mostly seen in postmenopausal women. Although no proven treatment for FFA exists, dutasteride has been suggested as a potential treatment option. Methods: Systematic search was performed from inception to 18 August 2022 using PubMed, Embase, Medline, Web of Science, and Scopus. According to the Preferred Reporting Items for Systematic Reviews and Meta-analysis 2020 criteria, identification and selection of the studies was conducted. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - August 21, 2023 Category: Dermatology Authors: H. Seo, S. Kim, J. Park, S. Oh, J. Kim Source Type: research
Systematic review of mesotherapy: a novel avenue for the treatment of hair loss
J Dermatolog Treat. 2023 Dec;34(1):2245084. doi: 10.1080/09546634.2023.2245084.ABSTRACTMesotherapy is a technique by which lower doses of therapeutic agents and bioactive substances are administered by intradermal injections to the skin. Through intradermal injections, mesotherapy can increase the residence time of therapeutic agents in the affected area, thus allowing for the use of lower doses and longer intervals between sessions which may in turn improve the treatment outcome and patient compliance. This systematic review aims to summarize the current literature that evaluates the efficacy of this technique for the tre...
Source: Journal of Dermatological Treatment - August 9, 2023 Category: Dermatology Authors: Aditya K Gupta Shruthi Polla Ravi Tong Wang Mesbah Talukder Michela Starace Bianca Maria Piraccini Source Type: research
GABA-ergic Modulators: New Therapeutic Approaches to Premenstrual Dysphoric Disorder
The objective of this narrative review is to discuss the plausible link between changes in GABAergic transmission secondary to the fluctuation of allopregnanolone during the luteal phase and mood impairment in susceptible individuals. As part of this discussion, we explore promising findings from early clinical trials of several compounds that stabilize allopregnanolone signaling during the luteal phase, including dutasteride, a 5-alpha reductase inhibitor; isoallopregnanolone, a GABA-A modulating steroid antagonist; and ulipristal acetate, a selective progesterone receptor modulator. We then reflect on the implications of...
Source: CNS Drugs - August 5, 2023 Category: Neurology Source Type: research
Use of 5-Alpha Reductase Inhibitors in Dermatology: A Narrative Review
AbstractFinasteride and dutasteride are 5-alpha reductase selective inhibitors (5ARIs). They were introduced as therapeutic agents for the treatment of benign prostatic hyperplasia in 1992 and 2002, respectively; finasteride has also been approved for the treatment of androgenetic alopecia since early 2000. These agents inhibit the conversion of testosterone (T) to 5 α-dihydrotestosterone (5α-DHT), limiting steroidogenesis and playing a crucial role in the physiological function of the neuroendocrine system. Therefore, it has been proposed that blocking androgen synthesis with the use of 5ARIs would be beneficial in the ...
Source: Dermatology and Therapy - July 11, 2023 Category: Dermatology Source Type: research
Manage androgenetic alopecia in men with established options but emerging therapies show promise
AbstractAndrogenetic alopecia (AGA) is the most common type of hair loss disorder and affects both men and women. It is characterized by the progressive miniaturization of hair follicles in androgenetic areas of the scalp resulting in a decrease in hair density. While the number of options for managing AGA has increased over the years, evidence-based information and guidelines are limited. Treatments range from the approved and off-label use of pharmacological agents [including oral 5 α-reductase inhibitors (e.g. dutasteride) and vasodilators (e.g. topical minoxidil)] to non-pharmacological treatments (e.g. low-level lase...
Source: Drugs and Therapy Perspectives - June 30, 2023 Category: Drugs & Pharmacology Source Type: research
Evaluation of the therapeutic effects of AGA drugs by measuring finasteride, dutasteride, and dihydrotestosterone in hair
CONCLUSIONS: Measurement of finasteride, dutasteride, and DHT concentrations in hair would aid in evaluating the drug pharmacokinetics and its therapeutic effects on AGA patients.PMID:37385468 | DOI:10.1016/j.cca.2023.117456 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - June 29, 2023 Category: Chemistry Authors: Yoshitaka Hobo Jun Nishikawa Noriko Asai-Taniguchi Keisuke Yoneyama Yoko Watanabe Yoshimichi Miyashiro Akira Fujikata Source Type: research
Evaluation of the therapeutic effects of AGA drugs by measuring finasteride, dutasteride, and dihydrotestosterone in hair
CONCLUSIONS: Measurement of finasteride, dutasteride, and DHT concentrations in hair would aid in evaluating the drug pharmacokinetics and its therapeutic effects on AGA patients.PMID:37385468 | DOI:10.1016/j.cca.2023.117456 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - June 29, 2023 Category: Chemistry Authors: Yoshitaka Hobo Jun Nishikawa Noriko Asai-Taniguchi Keisuke Yoneyama Yoko Watanabe Yoshimichi Miyashiro Akira Fujikata Source Type: research
“Exogenous” 5 Alpha Reductase Deficiency: A Case Report”
Testosterone and dihydrotestosterone are significant drivers of male external genital development, and therefore teratogens which alter these hormone profiles have been hypothesized to cause aberrations in development. Here, we present the first case report of genitalia anomalies after prenatal exposure to spironolactone and dutasteride through 8 weeks of gestation. The patient was born with abnormal male external genitalia which was surgically managed. Long term outcomes such as gender identity, sexual function, hormonal maturation through puberty, and fertility remain unknown. (Source: Urology)
Source: Urology - May 11, 2023 Category: Urology & Nephrology Authors: Brittany Levy, Seth Teplitsky, Evangelia Kalaitzoglou, Stephen Kahler, Juliann Paige Matheny, Amanda F. Saltzman Source Type: research
