Future aspects of plant derived bioactive metabolites as therapeutics to combat benign prostatic hyperplasia
CONCLUSION: The review proposes and endorses careful utilization of conventional medications that may be investigated further to discover possible PDE-5, 5 alpha-reductase, an alpha-blocker inhibitor for managing BPH. Even though most conventional formulations, such as 5 alpha-reductase, are readily available, systemic assessment of the effectiveness and mechanism of action of the herbal constituents is still necessary to identify novel chemical moieties that can be further developed for maximum efficacy. However, there exist abundant botanicals and medicinal plants across several regions of Africa, Asia, and the Americas,...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Raman Krishnamoorthi Anand Ganapathy A Hari Priya V M Alaganandam Kumaran Source Type: research
Expand the treatment horizon of premenstrual dysphoric disorder with targeted therapeutic approaches
AbstractPremenstrual dysphoric disorder (PMDD) is a sex-specific cyclic mood disorder characterized by heterogenous mood and physical symptoms during the luteal phase of the menstrual cycle. Currently available treatment options for PMDD are limited and suboptimal. With advanced understanding in pathophysiology of PMDD, the interaction between the gamma-aminobutyric acid (GABA) system and allopregnanolone, a neuroactive steroid derivative of progesterone, have been proposed as a potentially effective target for the treatment of PMDD. Although further research is needed, early clinical findings of new targeted treatments, s...
Source: Drugs and Therapy Perspectives - February 24, 2024 Category: Drugs & Pharmacology Source Type: research
Efficacy and safety of low-dose oral minoxidil in the management of androgenetic alopecia
Expert Opin Pharmacother. 2024 Feb 5:1-9. doi: 10.1080/14656566.2024.2314087. Online ahead of print.ABSTRACTINTRODUCTION: Treating alopecia can be challenging. The available treatments are topical minoxidil, low-dose oral minoxidil (LDOM), and 5-α reductase inhibitors like finasteride and dutasteride. Only topical minoxidil and finasteride 1 mg daily are FDA-approved, while the rest are used off-label. Recent research has suggested that oral minoxidil may be a safe and effective treatment for both female androgenetic alopecia (female AGA) and male androgenetic alopecia (male AGA).AREAS COVERED: In this review, we explore ...
Source: Expert Opinion on Pharmacotherapy - February 5, 2024 Category: Drugs & Pharmacology Authors: Aditya K Gupta Mesbah Talukder Avner Shemer Source Type: research
The use of beta-sitosterol for the treatment of prostate cancer and benign prostatic hyperplasia
Am J Clin Exp Urol. 2023 Dec 15;11(6):467-480. eCollection 2023.ABSTRACTHerbal supplements are widely used to enhance prostate health. These supplements may contain several types of plant sterols, vitamins, and minerals. By weight, however, plant sterols make up an abundant ingredient component, with saw palmetto extract or its primary component, beta-sitosterol, often comprising the most abundant sterol. Saw palmetto extract/beta-sitosterol has been shown to promote anti-tumorigenic processes in prostate cancer cells and rodent models of prostate cancer. It has also been shown to inhibit the 5α-reductase enzyme, thereby ...
Source: Clinical Prostate Cancer - December 27, 2023 Category: Cancer & Oncology Authors: Jill A Macoska Source Type: research
The use of beta-sitosterol for the treatment of prostate cancer and benign prostatic hyperplasia
Am J Clin Exp Urol. 2023 Dec 15;11(6):467-480. eCollection 2023.ABSTRACTHerbal supplements are widely used to enhance prostate health. These supplements may contain several types of plant sterols, vitamins, and minerals. By weight, however, plant sterols make up an abundant ingredient component, with saw palmetto extract or its primary component, beta-sitosterol, often comprising the most abundant sterol. Saw palmetto extract/beta-sitosterol has been shown to promote anti-tumorigenic processes in prostate cancer cells and rodent models of prostate cancer. It has also been shown to inhibit the 5α-reductase enzyme, thereby ...
Source: Clinical Prostate Cancer - December 27, 2023 Category: Cancer & Oncology Authors: Jill A Macoska Source Type: research
The use of beta-sitosterol for the treatment of prostate cancer and benign prostatic hyperplasia
Am J Clin Exp Urol. 2023 Dec 15;11(6):467-480. eCollection 2023.ABSTRACTHerbal supplements are widely used to enhance prostate health. These supplements may contain several types of plant sterols, vitamins, and minerals. By weight, however, plant sterols make up an abundant ingredient component, with saw palmetto extract or its primary component, beta-sitosterol, often comprising the most abundant sterol. Saw palmetto extract/beta-sitosterol has been shown to promote anti-tumorigenic processes in prostate cancer cells and rodent models of prostate cancer. It has also been shown to inhibit the 5α-reductase enzyme, thereby ...
Source: Clinical Prostate Cancer - December 27, 2023 Category: Cancer & Oncology Authors: Jill A Macoska Source Type: research
Medical Treatment for Androgenetic Alopecia
Facial Plast Surg DOI: 10.1055/a-2196-4713Androgenetic alopecia is a common type of hair loss, which is generally influenced by genetic factors and systemic androgens resulting in follicular miniaturization.1 It can cause cosmetic problems leading to psychological distress among affected men and women. Effective standard medical treatments available are topical minoxidil 2 to 5%, oral finasteride, oral dutasteride, and hair transplantation.1 However, some patients do not achieve favorable results with standard treatments. For these reasons, other novel treatments have been developed, including new medications, regenerative...
Source: Facial Plastic Surgery - December 4, 2023 Category: Cosmetic Surgery Authors: Panchaprateep, Ratchathorn Tags: Original Article Source Type: research
Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia
Conclusions: The DNA analysis of the patients with alopecia may contribute to a successful treatment.PMID:37763773 | PMC:PMC10537507 | DOI:10.3390/medicina59091654 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - September 28, 2023 Category: Universities & Medical Training Authors: Monica P ăun Gustavo Torres George Sorin Țiplica Victor Mihail Cauni Source Type: research
Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia
Conclusions: The DNA analysis of the patients with alopecia may contribute to a successful treatment.PMID:37763773 | PMC:PMC10537507 | DOI:10.3390/medicina59091654 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - September 28, 2023 Category: Universities & Medical Training Authors: Monica P ăun Gustavo Torres George Sorin Țiplica Victor Mihail Cauni Source Type: research
Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia
Conclusions: The DNA analysis of the patients with alopecia may contribute to a successful treatment.PMID:37763773 | PMC:PMC10537507 | DOI:10.3390/medicina59091654 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - September 28, 2023 Category: Universities & Medical Training Authors: Monica P ăun Gustavo Torres George Sorin Țiplica Victor Mihail Cauni Source Type: research
Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia
Conclusions: The DNA analysis of the patients with alopecia may contribute to a successful treatment.PMID:37763773 | PMC:PMC10537507 | DOI:10.3390/medicina59091654 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - September 28, 2023 Category: Universities & Medical Training Authors: Monica P ăun Gustavo Torres George Sorin Țiplica Victor Mihail Cauni Source Type: research
Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia
Conclusions: The DNA analysis of the patients with alopecia may contribute to a successful treatment.PMID:37763773 | PMC:PMC10537507 | DOI:10.3390/medicina59091654 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - September 28, 2023 Category: Universities & Medical Training Authors: Monica P ăun Gustavo Torres George Sorin Țiplica Victor Mihail Cauni Source Type: research
Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia
Conclusions: The DNA analysis of the patients with alopecia may contribute to a successful treatment.PMID:37763773 | PMC:PMC10537507 | DOI:10.3390/medicina59091654 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - September 28, 2023 Category: Universities & Medical Training Authors: Monica P ăun Gustavo Torres George Sorin Țiplica Victor Mihail Cauni Source Type: research
Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia
Conclusions: The DNA analysis of the patients with alopecia may contribute to a successful treatment.PMID:37763773 | PMC:PMC10537507 | DOI:10.3390/medicina59091654 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - September 28, 2023 Category: Universities & Medical Training Authors: Monica P ăun Gustavo Torres George Sorin Țiplica Victor Mihail Cauni Source Type: research
Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia
Conclusions: The DNA analysis of the patients with alopecia may contribute to a successful treatment.PMID:37763773 | PMC:PMC10537507 | DOI:10.3390/medicina59091654 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - September 28, 2023 Category: Universities & Medical Training Authors: Monica P ăun Gustavo Torres George Sorin Țiplica Victor Mihail Cauni Source Type: research
