Bioinformatics Identification of Ferroptosis-Related Biomarkers and Therapeutic Compounds in Ischemic Stroke
Conclusion: Our results suggested MAP1LC3B, PTGS2, and TLR4 as potential diagnostic biomarkers for ischemic stroke, providing more evidence about the vital role of ferroptosis in ischemic stroke. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - October 11, 2021 Category: Neurology Source Type: research
Effects of Cytochrome P450 and Transporter Polymorphisms on the Bioavailability and Safety of Dutasteride and Tamsulosin
Dutasteride and tamsulosin are one of the first-line combination therapies for the management of benign prostatic hyperplasia (BPH). Despite being more effective than monotherapies, they produce frequent adverse drug reactions (ADRs). Institutions such as Food and Drug Administration and European Medicines Agency recommend precaution with CYP2D6 poor metabolizers (PMs) that receive CYP3A4 inhibitors and tamsulosin. However, no specific pharmacogenetic guideline exists for tamsulosin. Furthermore, to date, no pharmacogenetic information is available for dutasteride. Henceforth, we studied the pharmacokinetics and safety of ...
Source: Frontiers in Pharmacology - October 7, 2021 Category: Drugs & Pharmacology Source Type: research
Effect of sex and gonadectomy on brain MPTP toxicity and response to dutasteride treatment in mice
In conclusion, sex differences in mice MPTP toxicity and response to dutasteride were observed that were lost upon gonadectomy implicating neuroinflammation.PMID:34555366 | DOI:10.1016/j.neuropharm.2021.108784 (Source: Neuropharmacology)
Source: Neuropharmacology - September 23, 2021 Category: Drugs & Pharmacology Authors: Amandine Isenbrandt Marc Morissette M élanie Bourque J érôme Lamontagne-Proulx Katherine Coulombe Denis Soulet Th érèse Di Paolo Source Type: research
Effect of sex and gonadectomy on brain MPTP toxicity and response to dutasteride treatment in mice
In conclusion, sex differences in mice MPTP toxicity and response to dutasteride were observed that were lost upon gonadectomy implicating neuroinflammation.PMID:34555366 | DOI:10.1016/j.neuropharm.2021.108784 (Source: Neuropharmacology)
Source: Neuropharmacology - September 23, 2021 Category: Drugs & Pharmacology Authors: Amandine Isenbrandt Marc Morissette M élanie Bourque J érôme Lamontagne-Proulx Katherine Coulombe Denis Soulet Th érèse Di Paolo Source Type: research
Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
CONCLUSIONS: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.PMID:34550196 | PMC:PMC8448540 | DOI:10.1590/ACB360703 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - September 22, 2021 Category: Surgery Authors: Marcello Henrique Ara újo da Silva Jo ão Henrique Duque Estrada Bianca Martins Greg ório Francisco Jos é Barcellos Sampaio Diogo Benchimol de Souza Source Type: research
Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
CONCLUSIONS: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.PMID:34550196 | PMC:PMC8448540 | DOI:10.1590/ACB360703 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - September 22, 2021 Category: Surgery Authors: Marcello Henrique Ara újo da Silva Jo ão Henrique Duque Estrada Bianca Martins Greg ório Francisco Jos é Barcellos Sampaio Diogo Benchimol de Souza Source Type: research
Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
CONCLUSIONS: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.PMID:34550196 | PMC:PMC8448540 | DOI:10.1590/ACB360703 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - September 22, 2021 Category: Surgery Authors: Marcello Henrique Ara újo da Silva Jo ão Henrique Duque Estrada Bianca Martins Greg ório Francisco Jos é Barcellos Sampaio Diogo Benchimol de Souza Source Type: research
Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
CONCLUSIONS: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.PMID:34550196 | PMC:PMC8448540 | DOI:10.1590/ACB360703 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - September 22, 2021 Category: Surgery Authors: Marcello Henrique Ara újo da Silva Jo ão Henrique Duque Estrada Bianca Martins Greg ório Francisco Jos é Barcellos Sampaio Diogo Benchimol de Souza Source Type: research
Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
CONCLUSIONS: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.PMID:34550196 | PMC:PMC8448540 | DOI:10.1590/ACB360703 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - September 22, 2021 Category: Surgery Authors: Marcello Henrique Ara újo da Silva Jo ão Henrique Duque Estrada Bianca Martins Greg ório Francisco Jos é Barcellos Sampaio Diogo Benchimol de Souza Source Type: research
Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
CONCLUSIONS: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.PMID:34550196 | DOI:10.1590/ACB360703 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - September 22, 2021 Category: Surgery Authors: Marcello Henrique Ara újo da Silva Jo ão Henrique Duque Estrada Bianca Martins Greg ório Francisco Jos é Barcellos Sampaio Diogo Benchimol de Souza Source Type: research
Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
CONCLUSIONS: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.PMID:34550196 | DOI:10.1590/ACB360703 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - September 22, 2021 Category: Surgery Authors: Marcello Henrique Ara újo da Silva Jo ão Henrique Duque Estrada Bianca Martins Greg ório Francisco Jos é Barcellos Sampaio Diogo Benchimol de Souza Source Type: research
Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
CONCLUSIONS: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.PMID:34550196 | PMC:PMC8448540 | DOI:10.1590/ACB360703 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - September 22, 2021 Category: Surgery Authors: Marcello Henrique Ara újo da Silva Jo ão Henrique Duque Estrada Bianca Martins Greg ório Francisco Jos é Barcellos Sampaio Diogo Benchimol de Souza Source Type: research
Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
CONCLUSIONS: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.PMID:34550196 | PMC:PMC8448540 | DOI:10.1590/ACB360703 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - September 22, 2021 Category: Surgery Authors: Marcello Henrique Ara újo da Silva Jo ão Henrique Duque Estrada Bianca Martins Greg ório Francisco Jos é Barcellos Sampaio Diogo Benchimol de Souza Source Type: research
Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
CONCLUSIONS: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.PMID:34550196 | PMC:PMC8448540 | DOI:10.1590/ACB360703 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - September 22, 2021 Category: Surgery Authors: Marcello Henrique Ara újo da Silva Jo ão Henrique Duque Estrada Bianca Martins Greg ório Francisco Jos é Barcellos Sampaio Diogo Benchimol de Souza Source Type: research
Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
CONCLUSIONS: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.PMID:34550196 | PMC:PMC8448540 | DOI:10.1590/ACB360703 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - September 22, 2021 Category: Surgery Authors: Marcello Henrique Ara újo da Silva Jo ão Henrique Duque Estrada Bianca Martins Greg ório Francisco Jos é Barcellos Sampaio Diogo Benchimol de Souza Source Type: research
