Catabodies to Degrade Transthyretin Amyloid
We describe nucleophilic catabodies from healthy humans without amyloidosis that degraded misfolded TTR (misTTR) without reactivity to the [correctly folded] TTR (phyTTR).
IgM class B cell receptors specifically recognized the electrophilic analog of misTTR but not phyTTR. IgM but not IgG class antibodies hydrolyzed the particulate and soluble misTTR species. No misTTR-IgM binding was detected. The IgMs accounted for essentially all of the misTTR hydrolytic activity of unfractionated human serum. The IgMs did not degrade non-amyloidogenic, non-superantigenic proteins.
The studies reveal a novel antibody property, the inn...
Source: Fight Aging! - June 17, 2014 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What is an autoinflammatory disease?
During our weekly physician conference, I discussed a patient with a suspected autoinflammatory disease. An elderly male, he had a history of recurrent fevers, hives, and elevated inflammatory markers, which had gone untreated for many years. Eventually, he developed renal amyloidosis, and was finally referred to rheumatology clinic for further evaluation. Although he had many of the classic signs and symptoms of an autoinflammatory disease, his physicians had not recognized it. His kidneys were failing, and he was being prepared to undergo hemodialysis as a result. Even during the case conference, in the prese...
Source: Kevin, M.D. - Medical Weblog - March 23, 2014 Category: Family Physicians Tags: Conditions Rheumatology Source Type: blogs
Low Voltage in Precordial Leads
A patient with was resuscitated from respiratory and cardiac arrest of uncertain etiology, but because she was very difficult to ventilate with BVM ventilation, and there were no ultrasonographic slidings signs, pneumothorax was suspected and bilateral needle thoracostomies were placed. This ECG was recorded:There is sinus tach and very low voltage in the precordial leads. It is otherwise unremarkable, especially for a patient who was in cardiac arrest.There was a previous ECG available:The low voltage is indeed new, and there is no change in limb lead voltageWhy is there low voltage?Although she was thought to ...
Source: Dr. Smith's ECG Blog - January 11, 2014 Category: Cardiology Authors: Steve Smith Source Type: blogs
Green Heart
by mk20 (Posted Thu Oct 17, 2013 8:15 pm)So the patient had primary amyloidosis, but it still seems to be a mystery why his heart was green. (Source: Med Student Guide)
Source: Med Student Guide - October 18, 2013 Category: Medical Students Source Type: forums
How to diagnose DCM with confidence by myocardial scar photography ?
While many of us are preoccupied with wires and balloons ,( coronary myopia ! ) , our radiology colleagues are making rapid strides . Let us spend some time to understand how the myocardial segments are inflicted the final insult . We need to realize , there is a pattern to this myocardial end game of scarring and fibrosis.
MRI is the gold standard to assess the myocardial architecture . It has a role in both assessing the anatomy , function , perfusion and viability .
LV function is assessed by cine MRI
Viability stud by delayed enhancement MRI (DEMRI , also called as LGE- Late Gadoli...
Source: Dr.S.Venkatesan MD - September 30, 2013 Category: Cardiology Authors: dr s venkatesan Tags: Cardiac MRI Cardiology -unresolved questions myocardial disease demri epicardial scars how to differentiate ischemic from non ischemic dcm late gadolinium enhancement lge gadolinium mid myocardial scar myocardial scar Imaging scar loca Source Type: blogs
Amyloid Angiopathy: MRI
64 year old male with a known chronic kidney
dysfunction & myocardial ischaemia
presence with altered sensorium. The MRI brain shows extensive parenchymal bleeds of varying sizes
in the entire cerebral, cerebellar parenchyma, basal ganglia & brain stem with T1
hyperintensity and blooming on SW with atheromatous circle of Willis branches
with no extra axial or intraventricular
extension, possibly representing cerebral amyloid angiopathy. Case submitted by
Dr MGK Murthy, Mr Venkat and Mr Senthil
Teaching points :
Predominantly
seen in elderly, and results from beta-amyloid...
Source: Sumer's Radiology Site - September 6, 2013 Category: Radiologists Authors: Sumer Sethi Source Type: blogs
Cardiology MCQ Online 4
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Source: Cardiophile MD - July 14, 2013 Category: Cardiology Authors: Prof. Dr. Johnson Francis MD, DM, FACC, FRCP Edin Tags: Cardiology MCQ DM / DNB Cardiology Entrance ECG Echocardiography Source Type: blogs
Cardiology MCQ Test 4
Cardiology MCQ Online 4
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You are welcome to try this MCQ set and share it among your friends. Answer key with explanation appears after you complete the test and submit it and press on the view questions button. W...
Source: Cardiophile MD - July 14, 2013 Category: Cardiology Authors: Prof. Dr. Johnson Francis MD, DM, FACC, FRCP Edin Tags: Cardiology MCQ DM / DNB Cardiology Entrance ECG Echocardiography Source Type: blogs
Limits on Cell Life Span Have Little To Do With Limits on Organism Life Span
Higher organisms like we humans are made of cells, of several hundred distinct types if you exclude all of the symbiotic bacterial species that we carry along with us. The vast majority of cells have short finite life spans: they stop reproducing and self-destruct or become senescent after a number of reproductive divisions. You might be familiar with the Hayflick limit in relation to this topic: it is the number of times a cell divides before it removes itself from the cell cycle to a fate of destruction or senescence. Similarly you have probably heard of telomeres, the repeating DNA sequences at the end of our chromosome...
Source: Fight Aging! - July 5, 2013 Category: Health Medicine and Bioethics Commentators Authors: Reason Tags: Of Interest Source Type: blogs
Amyloidosis: A Rare Disease that Affects Seniors
Amyloidosis is a rare disease that can affect the heart, kidney and liver functions among other things. This disease generally affects seniors, people on dialysis and people with Chronic Inflammatory Disease.Contributor: Michelle FosterPublished: Jun 18, 2013 (Source: Most Recent Health Wellness - Associated Content)
Source: Most Recent Health Wellness - Associated Content - June 18, 2013 Category: Other Conditions Source Type: blogs
Alzheimer's Miracle Drug Bexarotene Doesn't Work as Reported
“We all went back to our labs and tried to confirm these promising findings” ... “We repeated the initial experiments — a standard process in science. Combined results are really important in this field. None of us found anything like what they described in the 2012 paper.”
By +Bob DeMarco
+Alzheimer's Reading Room
Co-authors Karthikeyan Veeraraghavalu and
Sangram Sisodia of the University of Chicago
Three teams of highly respected Alzheimer’s researchers failed to replicate what appeared to be breakthrough results for the treatment of Alzheimer's disease using existing cancer drug Targretin® (br...
Source: Alzheimer's Reading Room, The - May 23, 2013 Category: Dementia Authors: Bob DeMarco Source Type: blogs
Goodbye, nephrotic syndrome!
Joanna posted this intriguing and wonderful tale of nephrotic syndrome reversed with wheat elimination:
No more nephrotic syndrome since starting
Wheat Belly–this is MASSIVE. I need to share my story Dr Davis.
I’m 30, I had heavy proteinuria [protein loss in the urine] for years. I went strictly wheat-free in July, 2012, and today I discovered its down to 0.5 g [per day]. No meds, just my interest in nutrition, in particular my 10 months on Wheat Belly. I’ve lost 20 kg [44 pounds], I weigh 54 kg [118.8 pounds] now, zero fluid retention, and the receptionist at the doctor’s office didn’t recogn...
Source: Wheat Belly Blog - May 16, 2013 Category: Cardiology Authors: Dr. Davis Tags: Wheat-elimination success stories Source Type: blogs
Rules of Stone
: Joel Topf, pbfluids.com William J Stone is Chief of Nephrology at the Tennessee Valley VA and faculty at Vanderbilt Medical School. He discovered beta-2 microglobulin amyloidosis in long term dialysis patients. He describes the discovery here: I discovered B2M amyloid… Posted on infosnack. (Source: Kidney Notes)
Source: Kidney Notes - April 15, 2013 Category: Urologists and Nephrologists Authors: Joshua Schwimmer Source Type: blogs
