(Non)-Exertional Variables of Cardiopulmonary Exercise Testing in Heart Failure with and Without Cardiac Amyloidosis
AbstractPurpose of ReviewCardiac amyloidosis (CA) constitutes an important etiology of heart failure with preserved ejection fraction (HFpEF) or heart failure with mildly reduced ejection fraction (HFmrEF). Since patients with CA show early exhaustion, we aimed to investigate whether non-exertional variables of cardiopulmonary exercise testing (CPET) provide additional information in comparison to traditional peak oxygen consumption (VO2peak).Recent FindingsWe retrospectively investigated CPET variables of patients with HFpEF and HFmrEF with (n = 21) and without (n = 21, HF) CA at comparable age and ejection fracti...
Source: Current Heart Failure Reports - April 18, 2024 Category: Cardiology Source Type: research
Sodium oligomannate's amelioration of reproductive and metabolic phenotypes in a letrozole-induced PCOS-like mouse model depends on the gut microbiome
In conclusion, the hyperinsulinemia and hyperandrogenemia of PCOS-like mice were alleviated by GV-971 intervention, which was associated with mitigating bile acid metabolism and modulating gut microbiota.PMID:38630889 | DOI:10.1093/biolre/ioae058 (Source: Biology of Reproduction)
Source: Biology of Reproduction - April 17, 2024 Category: Reproduction Medicine Authors: Zhi Li Yan Liu Yang Wang Qingqing Cai Yuhui Wang Yixuan Bai Haiou Liu Congjian Xu Feifei Zhang Source Type: research
ALECT2 amyloidosis with concurrent IgG4-related interstitial nephritis, membranous nephropathy and diabetic kidney disease: a case report and literature review
J Nephrol. 2024 Apr 17. doi: 10.1007/s40620-024-01924-9. Online ahead of print.ABSTRACTLeukocyte chemotactic factor-2 amyloidosis (ALECT2) is a recently described subtype of amyloidosis. IgG4-related disease is a rare fibroinflammatory condition characterized by dense interstitial lymphoplasmacytic infiltrates and fibrosis. Membranous nephropathy and diabetic nephropathy are common causes of nephrotic syndrome. Here we report a 49-year-old Hispanic male patient with diabetes mellitus who presented with jaundice and pruritus. IgG4-related autoimmune pancreatitis was diagnosed through laboratory workup and ampulla biopsy. He...
Source: Journal of Nephrology - April 17, 2024 Category: Urology & Nephrology Authors: Muhammad Shaheen Anchit Bharat Allon N Friedman Shunhua Guo Source Type: research
Sodium oligomannate's amelioration of reproductive and metabolic phenotypes in a letrozole-induced PCOS-like mouse model depends on the gut microbiome
In conclusion, the hyperinsulinemia and hyperandrogenemia of PCOS-like mice were alleviated by GV-971 intervention, which was associated with mitigating bile acid metabolism and modulating gut microbiota.PMID:38630889 | DOI:10.1093/biolre/ioae058 (Source: Reproductive Biology)
Source: Reproductive Biology - April 17, 2024 Category: Reproduction Medicine Authors: Zhi Li Yan Liu Yang Wang Qingqing Cai Yuhui Wang Yixuan Bai Haiou Liu Congjian Xu Feifei Zhang Source Type: research
Value of multi-modality small fiber assessments in a genotypically diverse cohort of transthyretin-related amyloidosis in the early stages of disease
CONCLUSIONS: In a diverse cohort of ATTRv patients, CCM was the most frequent abnormal measurement. CCM can be a useful test to triage patients in the early disease stages and with few or equivocal symptoms.PMID:38616431 | DOI:10.1016/j.medcli.2024.02.012 (Source: Medicina Clinica)
Source: Medicina Clinica - April 15, 2024 Category: General Medicine Authors: Monica Alcantara Shabber Mannan James de la Cruz Vera Bril Source Type: research
Exploring clinical variability in gelsolin amyloidosis: Brazilian family case study with confocal microscopy
We present three sisters with AGel amyloidosis, illustrating its clinical diversity. Patient 1, a 51-year-old, had bilateral ptosis, ocular discomfort, and dry eye syndrome due to cranial nerve involvement. Patient 2, a 53-year-old, experienced progressive bilateral visual impairment. Patient 3, a 50-year-old, exhibited right eye ectropion. Genetic analysis, with the identical mutation, heterozygous c.640G > A (p.Asp214Asn) mutation, confirmed AGel amyloidosis diagnoses, with common findings including lattice corneal amyloidosis, reduced corneal sensitivity, and recurrent corneal erosions. Neurological manifestations in...
Source: European Journal of Ophthalmology - April 15, 2024 Category: Opthalmology Authors: Caio Brenno Abreu B árbara Flores Culau Merlo Vin ícius da Silva Varandas Juliana de S á Freire Medrado Dias Source Type: research
Value of multi-modality small fiber assessments in a genotypically diverse cohort of transthyretin-related amyloidosis in the early stages of disease
CONCLUSIONS: In a diverse cohort of ATTRv patients, CCM was the most frequent abnormal measurement. CCM can be a useful test to triage patients in the early disease stages and with few or equivocal symptoms.PMID:38616431 | DOI:10.1016/j.medcli.2024.02.012 (Source: Medicina Clinica)
Source: Medicina Clinica - April 15, 2024 Category: General Medicine Authors: Monica Alcantara Shabber Mannan James de la Cruz Vera Bril Source Type: research
Chest pain in a patient with transthyretin cardiac amyloidosis: A case report
Key Clinical MessagePatients with transthyretin cardiac amyloidosis (ATTR-CM) commonly present with dyspnea, fatigue, and edema. In our case, the main presentation was exertional angina, which was atypical in patients with ATTR-CM and should be paid more attention to.AbstractA 54-year-old woman was admitted with a complaint of exertional chest pain, and she had a history of hypertension. The results of the electrocardiogram and echocardiography revealed the clues of cardiac amyloidosis, and the patient was finally diagnosed with transthyretin cardiac amyloidosis, then she received tafamidis, and the symptoms improved signi...
Source: Clinical Case Reports - April 15, 2024 Category: General Medicine Authors: Linfeng Xie,
Suxin Luo,
Bi Huang Tags: CASE REPORT Source Type: research
Minimal residual disease in systemic light chain amyloidosis: a systematic review and meta-analysis
ConclusionIn AL amyloidosis, our study supports that MRD negativity correlates with higher cardiac or renal response rates and indicates a better PFS in the follow-up. However, the correlation between OS and the status of MRD is not significant. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 15, 2024 Category: Cancer & Oncology Source Type: research
Erratum
to: “12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice,” by Di Meco et al. (Biol Psychiatry 2017; 81:92–100); https://doi.org/10.1016/j.biopsych.2016.05.023. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 15, 2024 Category: Psychiatry Tags: Erratum Source Type: research
Early diagnosis in ATTRv amyloidosis, how early is enough? How early is possible?
Med Clin (Barc). 2024 Apr 12:S0025-7753(24)00160-X. doi: 10.1016/j.medcli.2024.02.013. Online ahead of print.ABSTRACTHereditary transthyretin amyloidosis (ATTRv amyloidosis) is a rare, progressive, and debilitating genetic disorder characterized by the deposition of abnormal transthyretin (TTR) protein aggregates in various tissues, leading to organ dysfunction. Early diagnosis of ATTRv amyloidosis is critical for starting timely interventions and improving patient outcomes. This review explores the concepts of "how early is enough" and "how early is possible" in the context of diagnosing ATTRv amyloidosis, highlighting th...
Source: Medicina Clinica - April 13, 2024 Category: General Medicine Authors: Isabel Concei ção Source Type: research
Beta-blocking patients with cardiac amyloidosis: Adelante cum juicio
Once upon a time, beta-blockers (BB) were simply forbidden for the treatment of patients with heart failure (HF): they were thought to worsen clinical severity of the disease, eliciting salt/water retention, reducing myocardial contractility, impairing hemodynamics. [1] Therefore, although the first evidence of metoprolol efficacy was given in 1975, only 20 years after, in 1993, the first randomized study paved the way to a widespread use, finally guideline-recommended since 1999 up to 2021. [2] In the meanwhile, Packer's neurohormonal model of HF overcame the cardiocirculatory and cardiorenal ones. (Source: Internation...
Source: International Journal of Cardiology - April 12, 2024 Category: Cardiology Authors: Michele Emdin, Alberto Aimo, Giuseppe Vergaro, Vincenzo Castiglione Source Type: research
Acute ischemic stroke as initial manifestation of cardiac amyloidosis
(Source: Neurological Sciences)
Source: Neurological Sciences - April 11, 2024 Category: Neurology Source Type: research
Determinants of health status in older patients with transthyretin cardiac amyloidosis: a prospective cohort study
CONCLUSIONS: Functional status is a determinant of quality of life and health status in older individuals with a main diagnosis of ATTR-CA. Future research may provide more in-depth knowledge on the association of frailty in patients with ATTR-CA with respect to quality of life and prognosis.PMID:38598143 | DOI:10.1007/s40520-024-02750-6 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - April 10, 2024 Category: Geriatrics Authors: Carlo Fumagalli Lucia Ponti Martina Smorti Francesca Pozza Alessia Argir ò Mattia Zampieri Carlo Di Mario Raffaele Marfella Celestino Sardu Giuseppe Paolisso Iacopo Olivotto Federico Perfetto Andrea Ungar Niccol ò Marchionni Francesco Cappelli Source Type: research
Determinants of health status in older patients with transthyretin cardiac amyloidosis: a prospective cohort study
CONCLUSIONS: Functional status is a determinant of quality of life and health status in older individuals with a main diagnosis of ATTR-CA. Future research may provide more in-depth knowledge on the association of frailty in patients with ATTR-CA with respect to quality of life and prognosis.PMID:38598143 | PMC:PMC11006758 | DOI:10.1007/s40520-024-02750-6 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - April 10, 2024 Category: Geriatrics Authors: Carlo Fumagalli Lucia Ponti Martina Smorti Francesca Pozza Alessia Argir ò Mattia Zampieri Carlo Di Mario Raffaele Marfella Celestino Sardu Giuseppe Paolisso Iacopo Olivotto Federico Perfetto Andrea Ungar Niccol ò Marchionni Francesco Cappelli Source Type: research
