Fight Aging! Newsletter, July 3rd 2017
In conclusion, the analyses do not permit us to predict the trajectory that maximum lifespans will follow in the future, and hence provide no support for their central claim that the maximum lifespan of humans is "fixed and subject to natural constraints". This is largely a product of the limited data available for analysis, owing to the challenges inherent in collecting and verifying the lifespans of extremely long-lived individuals.
A reply from Jan Vijg's research group
The authors of the accompanying comment disagree with our finding of a limit to human lifespan. Although we thank them for alerting us...
Source: Fight Aging! - July 2, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A patient with shortness of breath
This 50-something with a history of alcohol abuse complained of 2 weeks of increasing dyspnea for 2 weeks, with some chest pain and cough. She was not ill-appearing.Her BP was 111/68, with a heart rate of 117, RR 22, Temp 36.4 C and SpO2 of 95%.She had a routine ECG performed at triage, as we do with all patients who are SOB.What do you think?I was brought this ECG and asked what I thought.I responded: there is very low voltage and tachycardia, does the ultrasound show an effusion?Here is the ED point of care ultrasound:There is a huge effusion with collapse of the RV. This is diagnostic of tamponade.A pigtail ca...
Source: Dr. Smith's ECG Blog - June 10, 2017 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, June 5th 2017
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - June 4, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A High Level View of the State of SENS Rejuvenation Research
The Life Extension Advocacy Foundation (LEAF) volunteers caught up with Aubrey de Grey of the SENS Research Foundation at the recent International Longevity and Cryopreservation Summit held in Spain, and hence the publication of the high level view of current progress in SENS rejuvenation research that I'll point out today. The conference was an opportunity for members the overlapping European communities focused on longevity science, cryonics, and transhumanism to present their work, build their networks, and plan future initiatives. When it comes to longevity, the SENS research program looms large: its focus on repair of...
Source: Fight Aging! - June 1, 2017 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Reviewing the Aging of Heart Tissue
This open access paper takes a brief tour of the dominant themes in the aging of heart tissue, viewed structurally and biochemically. These are some of the changes that have yet to be assembled into a coherent and generally agreed upon chain of events, starting with fundamental cellular damage, and proceeding through successive layers of cause and consequence in reaction to that damage. Most of the research community begins a line of inquiry with an investigation of one facet of the aged, diseased state. Researchers then attempt to work backwards to identify and address proximate causes of the observed problems, one by one...
Source: Fight Aging! - May 19, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
“ Long-term follow-up of curcumin treated MGUS/SMM patients – an updated single centre experience ”
In an email I received yesterday, Dr. Terry Golombick notified me that her team’s most recent article has been published in the Journal of Hematology and Medical Oncology. It is available for free online…just click here: goo.gl/cEP93h
Ahhhh. Wonderful…absolutely wonderful.
Wonderful, because finally…FINALLY (!!!)…we have a long-term look at a GROUP of MGUS and SMM patients taking curcumin. These are those who participated in the Australian MGUS/SMM study and who “continued to take curcumin over a number of years, of their own volition, even though the studies in which they were par...
Source: Margaret's Corner - May 12, 2017 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll blood cancers curcumin Dr. Terry Golombick MGUS myeloma SMM Source Type: blogs
RNA Interference as a Treatment for Transthyretin Amyloidosis
In this paper, the authors discuss RNA interference (RNAi) as the basis for therapies to treat (Source: Fight Aging!)
Source: Fight Aging! - March 16, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Potentially Useful New Finding in the Biochemistry of Amyloid- β
The research quoted below is illustrative of a great deal of investigation into Alzheimer's disease and related amyloid biochemistry. There is a vast depth of detail remaining to be explored, even in areas thought to be comparatively well-mapped. While much of that exploration is business as usual, leading to expected destinations and anticipated confirmations, there is always the chance of upheaval, as might be the case here. Alzheimer's disease, like many neurodegenerative conditions, is characterized by the aggregation of solid deposits of misfolded or otherwise altered proteins in brain tissue: amyloid-β and phosphory...
Source: Fight Aging! - March 13, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Calorie Restriction Slows Amyloid Accumulation in Mice
The practice of calorie restriction is shown to slow the progression of aging and extend healthy life in most species and lineages tested to date, including non-human primates. In humans the degree of life extension is a question mark, as the available data is exceedingly sparse, but the short-term changes are both very beneficial and very similar to those seen in other mammals. Given this, it should be unsurprising to find that calorie restriction slows any one particular aspect of aging, as is the case here for amyloid accumulation in tissues, one of the root causes of age-related disease and dysfunction in normal indivi...
Source: Fight Aging! - February 27, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Evidence for Gut Microbes to Speed Amyloid Buildup in Alzheimer's Disease
A great diversity of microbial life dwells inside us all, largely in the gut, and these microbes interact with our tissues and immune system in ways that the research community has only recently started to map in earnest. There are a handful of obvious and sometimes very serious medical conditions caused by the presence and inappropriate behavior of forms of microbe in the gut, but beyond this even the more common species are clearly an important component of the body as a whole. They play as great a role as many individual organs in determining health and pace of aging, one slice of the myriad complex interactions that ta...
Source: Fight Aging! - February 24, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Basis for an Antibody Therapy to Treat Transthyretin Amyloidosis
Misfolded transthyretin accumulates with age, forming solid amyloid deposits in tissues, particularly in the cardiovascular system. Amyloid disrupts proper function of cells and organs, and this is likely the majority cause of death in supercentenarians, the oldest humans. In recent years evidence has emerged for transthyretin amyloid to be involved in heart failure and a range of other conditions in younger old age, as well. There are a number of different approaches to clearing transthyretin amyloid under development, one of which has had a successful human trial, but progress towards the clinic is nonetheless exceedingl...
Source: Fight Aging! - February 24, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How green tea could help treat bone marrow disorders
Posted by Erika Ebsworth-Goold-WUSTL February 10th, 2017 http://www.futurity.org/amyloidosis-green-tea-1356282-2/ Scientists are investigating a compound found in green tea for often-fatal medical complications associated with bone-marrow disorders. Jan Bieschke of Washington University in St. Louis studies how proteins fold and shape themselves, and how these processes can contribute to a variety of diseases. He says the compound […] (Source: beth's myeloma blog)
Source: beth's myeloma blog - February 14, 2017 Category: Cancer & Oncology Authors: Beth Tags: Myeloma EGCG epigallocatechine-3-gallate green tea Source Type: blogs
An Indirect Test to Assess Risk of Cardiac Transthyretin Amyloidosis
In this study, researchers identified that a specific blood protein named retinol-binding protein 4 (RBP4) can be used to determine the likelihood of ATTR amyloidosis in a patient with congestive heart failure.
In addition the research team developed a mathematical calculator that incorporates RBP4 and other commonly ordered clinical tests that can be used to estimate the probability of ATTR amyloidosis in a given patient. An important advantage of this algorithm is that it can be used in the context of a doctor's office visit at the point-of-care. According to the researchers, this discovery could guide clinical de...
Source: Fight Aging! - February 9, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Amyloid and Tau have Synergistic Effects on the Progression of Alzheimer's Disease
This study revealed that the link between Aβ levels and progression to AD dementia depends on the p-tau status. This finding sheds light on the literature showing conflicting results reporting the association between Aβ and cognition. From a clinical perspective, if replicated, such a synergism has important implications in understanding the dynamics of progression to dementia. From a therapeutic perspective, one can derive important predictions from the existence of a synergistic interaction between Aβ and p-tau in AD. For example, one can predict that therapeutic interventions targeting either Aβ or p-tau pathology m...
Source: Fight Aging! - January 11, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
