Today's misleading overselling the #microbiome - U. Chicago on Alzheimer's and gut microbes
< a href="http://4.bp.blogspot.com/-i_wzC7Apkgo/V5IplrHZL_I/AAAAAAAKuOk/usgLJLhEnNARUqyVuE_Hp47pIhlyEZ1ygCK4B/s1600/overselling-1.jpg" imageanchor="1" > < img border="0" src="https://4.bp.blogspot.com/-i_wzC7Apkgo/V5IplrHZL_I/AAAAAAAKuOk/usgLJLhEnNARUqyVuE_Hp47pIhlyEZ1ygCK4B/s400/overselling-1.jpg" / > < /a > < br / > Well, this is disappointing if not disturbing < br / > < br / > A new paper is out that has some interesting findings but the paper itself, and the press release form the authors (at University of Chicago) really goes overboard in misstating the findings. < br / > < br / > Here is the < a href="http://www.nat...
Source: The Tree of Life - July 21, 2016 Category: Microbiology Authors: Jonathan Eisen Source Type: blogs
Fight Aging! Newsletter, July 18th 2016
In this study, a PET camera was used to examine individual differences in the D2 system in a group consisting of 181 healthy individuals between the age of 64 and 68. All participants also had to take part in an all-inclusive performance test of the long-term episodic memory, working memory and processing speed along with an MRI assessment (which was used to measure the size of various parts of the brain). Researchers could see that the D2 system was positively linked to episodic memory, but not to working memory or to processing speed by relating PET registrations to the cognitive data. Researchers could also see that the...
Source: Fight Aging! - July 17, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Investigating the Mechanisms of Transthyretin Amyloid Aggregation
In transthyretin amyloidosis, also known as senile systemic amyloidosis when it occurs in the elderly, the protein transthyretin misfolds to precipitate into solid masses. This occurs to varying degrees over the course of aging for all of us, and it is becoming clear that these amyloid aggregates contribute meaningfully to the progression of heart disease, among other conditions. It also seems that transthyretin amyloidosis is what finally kills most supercentenarians, the oldest of people who evade every other fatal age-related condition.
There is a potential therapy to break down this form of amyloid that last yea...
Source: Fight Aging! - July 13, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
DM / DNB Cardiology Entrance New Test Series 3
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Source: Cardiophile MD - July 9, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Featured Source Type: blogs
Cardiac amyloidosis – Cardiology MCQ
Pick the wrong statement:
a) Light chain cardiac amyloidosis has a better survival than transthyretin cardiac amyloid amyloidosis
b) Light chain cardiac amyloidosis responds to chemotherapy
c) Transthyretin cardiac amyloidosis is associated with sensorimotor polyneuropathy
d) Transthyretin cardiac amyloidosis can be detected by bone scintigraphy
Correct answer: a) Light chain cardiac amyloidosis has a better survival than transthyretin cardiac amyloid amyloidosis
Light chain amyloidosis with left ventricular systolic failure has median survival of 4 months while transthyretin amyloidosis has a median survival of 3-6 years...
Source: Cardiophile MD - June 29, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
A New Method for Early Detection of Amyloid in Aging Tissues
Better methods of detecting the various forms of amyloid as it builds up in tissues with age should result in greater support for development and availability of the means to remove this unwanted form of metabolic waste. Amyloids are present in every individual to some degree, that presence increasing with age, and are known to cause or be associated with numerous age-related diseases. This is one of the fundamental forms of damage that causes aging, yet amyloid levels are rarely assessed in healthy individuals, or even for patients with diseases that are relevant but something other than full-blown amyloidosis. Ideally ev...
Source: Fight Aging! - March 23, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Existing Drug Found to Slow Progression of Transthyretin Amyloidosis
Researchers have discovered that an existing drug can slow the progression of rare forms of transthyretin amyloidosis caused by mutation by interfering in the formation of this type of amyloid. It is unclear as to how useful this would be in practice for the age-related accumulation of transthyretin amyloid known as senile systemic amyloidosis that occurs in every individual, however, as that happens at a much slower pace over a greater span of time. The growing presence of this amyloid is implicated in a range of age-related conditions, particular cardiovascular disease. The ideal approach to amyloidosis, whether age-rela...
Source: Fight Aging! - February 24, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What Next for Transthyretin Amyloid Clearance Therapies?
If aging is damage, specific forms of cellular and molecular disarray, then rejuvenation is achieved through periodic repair of that damage. This is the Strategies for Engineered Negligible Senescence (SENS) vision for the future of treating aging, and it is a task that the medical research community is only just getting started on in any real way, sad to say. We are more than a decade in to advocacy and modest funding for SENS, and some progress has been achieved, however. Setting aside stem cell research and the amyloid clearing efforts of the Alzheimer's research community, as in both of those cases it is very hard to p...
Source: Fight Aging! - February 1, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Rejuvenation Biotechnology Update for Q1 2016
The Rejuvenation Biotechnology Update is a collaboration between the Methuselah Foundation and SENS Research Foundation, a newsletter delivered to SENS supporters and members of the Methuselah Foundation 300. The latest edition arrived yesterday, and as usual it is a look at a few of the interesting research results from recent months, with accompanying explanations of their relevance in the bigger picture.
The 300 is a group of donors who have supported the Methuselah Foundation for more than a decade now, and the first members stepped up to help get the first initiatives off the ground back when there were only ideas an...
Source: Fight Aging! - January 28, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
DM / DNB Cardiology Entrance Mock Test 6
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Source: Cardiophile MD - January 22, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Transthyretin Amyloid May Contribute to the Progression of Cartilage Damage and Osteoarthritis
Earlier this year researchers published evidence suggesting that rising levels of transthyretin (TTR) amyloid may contribute to age-related damage to cartilage tissue in joints and consequent development of osteoarthritis. Amyloids of various types accumulate in tissue with advancing age, each resulting from a different misfolded protein whose altered properties in that state cause it to form solid deposits. The biochemistry of this process is different in each case, and usually complex and incompletely understood. You don't have to look any further than the field of Alzheimer's research and the still dominant amyloid hypo...
Source: Fight Aging! - November 20, 2015 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
On the Role of α-synuclein in Parkinson's Disease
Parkinson's disease, like dementia with Lewy bodies, is a synucleinopathy, a condition characterized by the buildup of aggregates of misfolded, toxic α-synuclein that cause cell death in the brain. The mix of age-related cellular damage, evolved reactions to that damage, and individual genetic variance that leads to the creation of these aggregates is highly complex and poorly understood. As for other diseases involving forms of protein aggregate that harm tissues, such as the varied forms of amyloidosis, one possible shortcut to meaningful treatment is to clear the aggregates on a regular basis. The research community is...
Source: Fight Aging! - November 3, 2015 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Large Kidneys What Do They Mean?
Usually kidney disease is associated with small kidneys. The process that shrinks the kidney is scarring otherwise known as fibrosis which is the end point of any damage to the kidney. However from time to time a disease process will come along that causes enlargement of the kidney as it proceeds to damage the kidney. Some of the diseases that may cause this are as follows.
Infiltrative diseases such as sarcoidosis and amyloidosis both cause this. Amyloidosis is a disease of the blood which bears certain similarities with multiple myeloma and may coexist with this condition. There is deposition of large quantities of abno...
Source: All Kidney News - September 29, 2015 Category: Urology & Nephrology Authors: jadhavbca Tags: Kidney News HIV Source Type: blogs
A Review of Work on Targeting α-synuclein Aggregates
Here I'll point out a recent review of approaches to treat one of the more common synucleinopathies, conditions related to - and thought to be caused by - the abnormal accumulation of α-synuclein in tissues. The pathologies of numerous age-related diseases are linked to various different types of protein aggregate that are observed to build up with age: misfolded or simply overabundant proteins that precipitate to form solid clumps and fibrils. Amyloids are well known for their association with Alzheimer's disease, but there are many types of amyloid and many corresponding amyloidosis conditions. Similarly tau aggregates ...
Source: Fight Aging! - September 18, 2015 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
2 weeks of chest pain, weakness. Presents with tachycardia.
A middle-aged male with no significant past history complained of chest pain for 2 weeks. He stated that it was intermittent and there were no identifiable triggers. The pain was located at upper left chest without radiation and was "sharp" and aggravated by deep inspiration. He endorses some SOB.On exam he appeared somewhat lethargic, with a normal body habitus, and had the following vital signs: BP 116/77 mmHg | Pulse 117 | Temp(Src) 36.4 °C (97.5 °F) | Resp 16 | SpO2 95%.Cardiac exam was normal. There was bilateral mild pitting edema.An ECG was recorded:What do you think and what do you want to...
Source: Dr. Smith's ECG Blog - August 21, 2015 Category: Cardiology Authors: Steve Smith Source Type: blogs
