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Mechanisms of Bacterial Drug Resistance with Special Emphasis on Phenotypic and Molecular Characterization of Extended Spectrum Beta-lactamase
New Microbiol. 2024 May;47(1):1-14.ABSTRACTAntibiotics are designed to effectively treat bacterial infections while minimizing harm to the human body. They work by targeting specific components of bacteria or by disrupting essential processes such as cell wall synthesis, membrane function, protein production, and metabolic pathways. However, the misuse and overuse of antibiotics have led to the emergence of drug resistance in humans, animals, and agriculture, contributing to the global spread of this problem. Drug resistance can be either innate or acquired, with acquired resistance involving changes in the bacterial chrom...
Source: New Microbiologica - May 3, 2024 Category: Microbiology Authors: Daniel Geleta Gemeda Abebe Bikila Alemu Netsanet Workneh Getenet Beyene Source Type: research

Immuno-modulatory role of baicalin in atherosclerosis prevention and treatment: current scenario and future directions
Front Immunol. 2024 Apr 18;15:1377470. doi: 10.3389/fimmu.2024.1377470. eCollection 2024.ABSTRACTAtherosclerosis (AS) is recognized as a chronic inflammatory condition characterized by the accumulation of lipids and inflammatory cells within the damaged walls of arterial vessels. It is a significant independent risk factor for ischemic cardiovascular disease, ischemic stroke, and peripheral arterial disease. Despite the availability of current treatments such as statins, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, and lifestyle modifications for prevention, AS remains a leading cause of morbidity and ...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Li Wang Shenyi Huang Xiaolun Liang Junliang Zhou Yifan Han Jiangshan He Danping Xu Source Type: research

Investigation of usage, attitudes toward complementary and alternative medicine among cancer patients in Turkey during COVID-191
CONCLUSION: Due to the high prevalence of CAM usage among cancer patients and possible interaction effects with chemotherapy medications, it is important for healthcare professionals to assess and educate cancer patients regarding CAM use. Additional research is needed to determine potential interactions, as well as pros and cons of CAM use during cancer treatment.PMID:38701169 | DOI:10.3233/WOR-230195 (Source: Work)
Source: Work - May 3, 2024 Category: Occupational Health Authors: Ezgi Genc Irem Bulut Source Type: research

Ammodaucus Leucotrichus Seed Extract as a Potential Therapy in Animal Models of Rheumatoid Arthritis Induced by Complete Freund Adjuvant and Chicken Cartilage Collagen
This study assessed the efficacy of an Ammodaucus leucotrichus seed extract to treat rheumatoid arthritis in rat models of this disease. Rheumatoid arthritis was induced in rats using two methods: immunization with 100 µL of Complete Freund Adjuvant (CFA) and immunization with 100 µL of a 3 mg/ml solution of type II collagen (CII) from chicken cartilage. The therapeutic potential of the extract was assessed at different doses (150, 300, and 600 mg/kg/day for 21 days in the CII-induced arthritis model and for 14 days in the CFA-induced arthritis model) and compared with methotrexate (MTX; 0.2 mg/kg for the same periods), ...
Source: Applied Biochemistry and Biotechnology - May 3, 2024 Category: Biochemistry Authors: Cheima Djehiche Nadia Benzidane Hanene Djeghim Mehdi Tebboub Saad Mebrek Katia Abedelouhab Abderrahmane Baghiani Noureddine Charef Mohammed Messaoudi Chawki Bensouici Rabah Lebsir Talha Bin Emran Ali Alsalme David Cornu Mikhael Bechelany Lekhmici Arrar Ah Source Type: research

Effects of hand-press pellet on pain and daily life of elders with chronic lower back pain: randomized controlled trial
For elderly people with chronic lower back pain who need long-term management, there is a need for a nursing intervention study that is effective, is easy to perform, and applies complementary and alternative ... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - May 3, 2024 Category: Complementary Medicine Authors: Hyojung Park and Hyejin Lee Tags: Research Source Type: research

PRECIS-2 analysis of pragmatic acupuncture trials: a systematic review
This study aimed to provide a comprehensive methodological analysis of... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - May 3, 2024 Category: Complementary Medicine Authors: Jinwoong Lim, Hyeonhoon Lee and Yong-Suk Kim Tags: Research Source Type: research

New synergistic combination therapy approaches with HDAC inhibitor quisinostat, cisplatin or PARP inhibitor talazoparib for urothelial carcinoma
In conclusion, our results suggest new promising combination regimes for treatment of UC, also in the cisplatin-resistant setting.PMID:38693852 | DOI:10.1111/jcmm.18342 (Source: Cancer Control)
Source: Cancer Control - May 2, 2024 Category: Cancer & Oncology Authors: Sarah Meneceur Caroline E De Vos Patrick Petzsch Karl K öhrer G ünter Niegisch Mich èle J Hoffmann Source Type: research

Probiotic formulations and gastro-intestinal diseases in the paediatric population: a narrative review
CONCLUSION: This study concludes that single-organism and composite probiotics are effective complementary therapies for treating gastrointestinal disorders in the pediatric population. Hence, healthcare professionals should consider using probiotics in standard treatment regimens, and educating guardians can enhance the benefits of probiotic therapy. Further research is recommended to identify the optimal strains and dosages for specific conditions and demographics. The integration of probiotics in clinical practice and ongoing research can contribute to reducing the incidence and severity of gastrointestinal disorders in...
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Amna Siddiqui Ramsha Haider Syeda Ilsa Aaqil Laiba Imran Vohra Khulud Qamar Areesha Jawed Nabeela Fatima Alishba Adnan Vidhi Parikh Sidhant Ochani Md Al Hasibuzzaman Source Type: research

Probiotic formulations and gastro-intestinal diseases in the paediatric population: a narrative review
CONCLUSION: This study concludes that single-organism and composite probiotics are effective complementary therapies for treating gastrointestinal disorders in the pediatric population. Hence, healthcare professionals should consider using probiotics in standard treatment regimens, and educating guardians can enhance the benefits of probiotic therapy. Further research is recommended to identify the optimal strains and dosages for specific conditions and demographics. The integration of probiotics in clinical practice and ongoing research can contribute to reducing the incidence and severity of gastrointestinal disorders in...
Source: Hand Surgery - May 2, 2024 Category: Surgery Authors: Amna Siddiqui Ramsha Haider Syeda Ilsa Aaqil Laiba Imran Vohra Khulud Qamar Areesha Jawed Nabeela Fatima Alishba Adnan Vidhi Parikh Sidhant Ochani Md Al Hasibuzzaman Source Type: research

New synergistic combination therapy approaches with HDAC inhibitor quisinostat, cisplatin or PARP inhibitor talazoparib for urothelial carcinoma
In conclusion, our results suggest new promising combination regimes for treatment of UC, also in the cisplatin-resistant setting.PMID:38693852 | DOI:10.1111/jcmm.18342 (Source: J Cell Mol Med)
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Sarah Meneceur Caroline E De Vos Patrick Petzsch Karl K öhrer G ünter Niegisch Mich èle J Hoffmann Source Type: research

Emerging therapies for overactive bladder: preclinical, phase I and phase II studies
Expert Opin Investig Drugs. 2024 May 2. doi: 10.1080/13543784.2024.2349285. Online ahead of print.ABSTRACTINTRODUCTION: Overactive bladder syndrome is a common chronic condition with a significant impact on quality of life and economic burden. Persistence with pharmacologic therapy has been limited by efficacy and side effects. A greater understanding of the pathophysiology of overactive bladder has led to the initial evaluation of several drugs affecting ion channels, the autonomic nervous system, and enzymes which may provide useful alternatives for the management of overactive bladder.AREAS COVERED: A comprehensive revi...
Source: Expert Opinion on Investigational Drugs - May 2, 2024 Category: Drugs & Pharmacology Authors: Samantha Gibson Pamela Ellsworth Source Type: research

New synergistic combination therapy approaches with HDAC inhibitor quisinostat, cisplatin or PARP inhibitor talazoparib for urothelial carcinoma
In conclusion, our results suggest new promising combination regimes for treatment of UC, also in the cisplatin-resistant setting.PMID:38693852 | DOI:10.1111/jcmm.18342 (Source: Molecular Medicine)
Source: Molecular Medicine - May 2, 2024 Category: Molecular Biology Authors: Sarah Meneceur Caroline E De Vos Patrick Petzsch Karl K öhrer G ünter Niegisch Mich èle J Hoffmann Source Type: research

Equine-Assisted Service's Effect on Cartilage and Skeletal Biomarkers for Adults and Older Adults with Arthritis: A Pilot Study
CONCLUSION: Although equine-assisted therapy may reduce pain and improve quality of life for adults with arthritis, findings here are not fully corroborated with biomarkers.PMID:38697487 | DOI:10.1016/j.ctim.2024.103047 (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - May 2, 2024 Category: Complementary Medicine Authors: Matthew Chrisman Sharon White-Lewis Sue Lasiter Steven R Chesnut Cynthia L Russell Source Type: research

Probiotic formulations and gastro-intestinal diseases in the paediatric population: a narrative review
CONCLUSION: This study concludes that single-organism and composite probiotics are effective complementary therapies for treating gastrointestinal disorders in the pediatric population. Hence, healthcare professionals should consider using probiotics in standard treatment regimens, and educating guardians can enhance the benefits of probiotic therapy. Further research is recommended to identify the optimal strains and dosages for specific conditions and demographics. The integration of probiotics in clinical practice and ongoing research can contribute to reducing the incidence and severity of gastrointestinal disorders in...
Source: Hand Surgery - May 2, 2024 Category: Surgery Authors: Amna Siddiqui Ramsha Haider Syeda Ilsa Aaqil Laiba Imran Vohra Khulud Qamar Areesha Jawed Nabeela Fatima Alishba Adnan Vidhi Parikh Sidhant Ochani Md Al Hasibuzzaman Source Type: research