Current Diagnostic and Therapeutic Practices in Alopecia Areata in Two Mediterranean Countries: A Survey-Based Study
ConclusionsOur results highlight that management of AA, in terms of diagnosis and treatment, is still challenging. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - April 10, 2024 Category: Dermatology Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Patient-Reported Burden of Severe Alopecia Areata: First Results from the Multinational Alopecia Areata Unmet Need Survey
CONCLUSION: The study emphasizes the substantial burden, including impaired quality of life and psychological well-being, of severe AA on the lives of surveyed participants. The findings highlight the importance of comprehensive disease management strategies that address both physical and psychosocial aspects of AA.PMID:38566887 | PMC:PMC10986409 | DOI:10.2147/CCID.S445646 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - April 3, 2024 Category: Dermatology Authors: Anthony Bewley Ignasi Figueras-Nart Jainzhong Zhang Mariana Guerreiro Nicole Tietz Sami Chtourou Frederick Durand Ulrike Blume-Peytavi Source Type: research
