The role of thymic stromal lymphopoietin in cutaneous disorders
AbstractThymic Stromal Lymphopoietin (TSLP) is an important cytokine that invokes early immune responses. TSLP, an IL-7-like cytokine encoded by theTSLP gene, activates JAK1 and JAK2 signaling pathways, stimulating dendritic cells to induce inflammatory Th2 cells. This cytokine is associated with pruritus in various cutaneous disorders, particularly atopic dermatitis. Varying levels of the cytokine TSLP have been demonstrated in studies of different cutaneous disorders. Pharmacological treatment targeting TSLP has been explored recently, particularly in the realm of atopic dermatitis.This review explores the relation of TS...
Source: Archives of Dermatological Research - April 17, 2024 Category: Dermatology Source Type: research
Lasers in the management of alopecia: a review of established therapies and advances in treatment
AbstractAlopecia, also known as hair loss, is a highly prevalent condition affecting millions of men and women in the United States and worldwide, making it one of the most common complaints by patients presenting to a dermatologist. The symptomology on the presentation of alopecia can be highly variable, ranging from diffuse thinning of hair, discrete and localized patches completely absent of hair, or noticing significant shedding when brushing and showering. Although alopecia does not have a direct negative health impact on patients, it is nonetheless a debilitating disease as it can profoundly impact an individual ’s...
Source: Lasers in Medical Science - April 17, 2024 Category: Laser Surgery Source Type: research
The Epidemiology of Hospital-Treated Alopecia Areata in Denmark, 1995 –2016
ConclusionThis cohort study reported incidence rates and prevalence over time and characteristics of individuals with hospital-treated AA in Denmark, which are in agreement with those previously reported in this population. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - April 16, 2024 Category: Dermatology Source Type: research
Comment on “Baricitinib for the Treatment of Alopecia Areata in Adults: Real World Analysis of 36 Patients”
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 15, 2024 Category: Dermatology Authors: Deesha Desai, Ambika Nohria, Jerry Shapiro, Kristen Lo Sicco Source Type: research
Elevation of circulating DNAs of disease-associated cytokines in serum cell-free DNA from patients with alopecia areata
In this study, we aimed to investigate the clinical significance of cfDNA and the circulating DNAs of disease-associated cytokines in AA patients. Serum samples were obtained from 63 patients with AA and 32 healthy controls (HC). Using droplet digital polymerase chain reaction, circulating C-X-C motif chemokine ligand (CXCL) 9, CXCL10, CXCL11, C-X-C motif chemokine receptor 3, interferon (IFN)-γ, interleukin (IL) -7, IL-15, and Janus kinase (JAK) 2 were detectable in both HC and AA patients. Among the detectable DNAs, copies of circulating CXCL9, CXCL11, IL-15, IFN-γ, and JAK2 were significantly higher in AA patients tha...
Source: BioScience Trends - April 14, 2024 Category: Biomedical Science Authors: Soichiro Sawamura Tselmeg M Myangat Ikko Kajihara Katsunari Makino Jun Aoi Shinichi Masuguchi Satoshi Fukushima Source Type: research
Current Diagnostic and Therapeutic Practices in Alopecia Areata in Two Mediterranean Countries: A Survey-Based Study
ConclusionsOur results highlight that management of AA, in terms of diagnosis and treatment, is still challenging. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - April 10, 2024 Category: Dermatology Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
Interleukin-15 is a hair follicle immune privilege guardian
J Autoimmun. 2024 Apr 5;145:103217. doi: 10.1016/j.jaut.2024.103217. Online ahead of print.ABSTRACTThe autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo. Quantitati...
Source: Journal of Autoimmunity - April 6, 2024 Category: Allergy & Immunology Authors: Takahiro Suzuki J érémy Chéret Fernanda S Dinelli Ali Rajabi-Estarabadi Aysun Akhundlu Dana-Lee Demetrius Jennifer Gherardini Aviad Keren Matthew Harries Jose Rodriguez-Feliz Gorana Epstein-Kuka Wendy Lee Talveen Purba Amos Gilhar Ralf Paus Source Type: research
