Medicarpin suppresses lung cancer cell growth < em > in vitro < /em > and < em > in vivo < /em > by inducing cell apoptosis
This study was de sig ned to evaluate the anti-LC effect and reveal the underlying mechanisms of MED in vivo and in vitro. We found that MED could significantly inhibit proliferation, induce apoptosis, and cell cycle arrest of A549 and H157 cell lines. Basically, MED induced cell apoptosis of LC cells by upregu lating the expression of pro-apoptotic proteins BAX and Bak1, leading to the cleavage of caspase-3 (Casp3). Moreover, MED inhibited the proliferation of LC cells via downregulating the expression of proliferative protein Bid. Overall, MED inhibited LC cell growth in vitro and in vivo via suppressing cell proliferati...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Zongyi Shen Liqi Yin Manxia Chang Haifeng Wang Mingxuan Hao Youfeng Liang Rui Guo Ying Bi Jiansong Wang Changyuan Yu Jinmei Li Qiongli Zhai Runfen Cheng Jinku Zhang Jirui Sun Zhao Yang Source Type: research
Medicarpin suppresses lung cancer cell growth < em > in vitro < /em > and < em > in vivo < /em > by inducing cell apoptosis
This study was de sig ned to evaluate the anti-LC effect and reveal the underlying mechanisms of MED in vivo and in vitro. We found that MED could significantly inhibit proliferation, induce apoptosis, and cell cycle arrest of A549 and H157 cell lines. Basically, MED induced cell apoptosis of LC cells by upregu lating the expression of pro-apoptotic proteins BAX and Bak1, leading to the cleavage of caspase-3 (Casp3). Moreover, MED inhibited the proliferation of LC cells via downregulating the expression of proliferative protein Bid. Overall, MED inhibited LC cell growth in vitro and in vivo via suppressing cell proliferati...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Zongyi Shen Liqi Yin Manxia Chang Haifeng Wang Mingxuan Hao Youfeng Liang Rui Guo Ying Bi Jiansong Wang Changyuan Yu Jinmei Li Qiongli Zhai Runfen Cheng Jinku Zhang Jirui Sun Zhao Yang Source Type: research
Medicarpin suppresses lung cancer cell growth < em > in vitro < /em > and < em > in vivo < /em > by inducing cell apoptosis
This study was de sig ned to evaluate the anti-LC effect and reveal the underlying mechanisms of MED in vivo and in vitro. We found that MED could significantly inhibit proliferation, induce apoptosis, and cell cycle arrest of A549 and H157 cell lines. Basically, MED induced cell apoptosis of LC cells by upregu lating the expression of pro-apoptotic proteins BAX and Bak1, leading to the cleavage of caspase-3 (Casp3). Moreover, MED inhibited the proliferation of LC cells via downregulating the expression of proliferative protein Bid. Overall, MED inhibited LC cell growth in vitro and in vivo via suppressing cell proliferati...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Zongyi Shen Liqi Yin Manxia Chang Haifeng Wang Mingxuan Hao Youfeng Liang Rui Guo Ying Bi Jiansong Wang Changyuan Yu Jinmei Li Qiongli Zhai Runfen Cheng Jinku Zhang Jirui Sun Zhao Yang Source Type: research
Mechanism of action of microRNA166 on nitric oxide in alfalfa (Medicago sativa L.) under drought stress
Alfalfa is a perennial forage crop of high importance, but its cultivation is often affected by drought stress. Currently, the investigation of drought-related small RNAs is a popular research topic to uncover... (Source: BMC Genomics)
Source: BMC Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Bochuang Wei, Yizhen Wang, Qian Ruan, Xiaolin Zhu, Xian Wang, Tianjie Wang, Ying Zhao and Xiaohong Wei Tags: Research Source Type: research
Molecules, Vol. 29, Pages 1226: Structure, Absolute Configuration, Antiproliferative and Phytotoxic Activities of Icetexane and Abietane Diterpenoids from Salvia carranzae and Chemotaxonomic Implications
ero Esquivel
From the aerial parts of Salvia carranzae Zamudio and Bedolla, three new icetexane-type diterpenoids were isolated. Their structures were established through spectroscopic methods and named the following: salvicarranzanolide (1), 19-deoxo-salvicarranzanolide (2) and 19-deoxo-20-deoxy-salvicarranzanolide (3). In addition, the known icetexane-type diterpenoids, 6,7,11,14-tetrahydro-7-oxo-icetexone (4), iso-icetexone (5), 19-deoxo-iso-icetexone (6), icetexone (7), 19-deoxo-icetexone (8) and 7&alpha;-acetoxy-6,7-dihydroicetexone (9), were also isolated, along with the abietanes sessein (10) and ferrugi...
Source: Molecules - March 9, 2024 Category: Chemistry Authors: Celia Bustos-Brito Juan Pablo Torres-Medicis Brenda Y. Bedolla-Garc ía Sergio Zamudio Teresa Ram írez-Apan Martha Lydia Mac ías-Rubalcava Leovigildo Quijano Baldomero Esquivel Tags: Article Source Type: research
Regulation of endogenous hormone and miRNA in leaves of alfalfa (Medicago sativa L.) seedlings under drought stress by endogenous nitric oxide
Alfalfa (Medicago sativa. L) is one of the best leguminous herbage in China and even in the world, with high nutritional and ecological value. However, one of the drawbacks of alfalfa is its sensitivity to dry co... (Source: BMC Genomics)
Source: BMC Genomics - March 1, 2024 Category: Genetics & Stem Cells Authors: Qian Ruan, Xiaoming Bai, Yizhen Wang, Xiaofang Zhang, Baoqiang Wang, Ying Zhao, Xiaolin Zhu and Xiaohong Wei Tags: Research Source Type: research
Improving productivity and soil fertility in Medicago sativa and Hordeum marinum through intercropping under saline conditions
Intercropping is an agriculture system used to enhance the efficiency of resource utilization and maximize crop yield grown under environmental stress such as salinity. Nevertheless, the impact of intercroppin... (Source: BMC Plant Biology)
Source: BMC Plant Biology - March 1, 2024 Category: Biology Authors: Amal Guerchi, Wiem Mnafgui, Cheima Jabri, Meriem Merghni, Kalthoum Sifaoui, Asma Mahjoub, Ndiko Ludidi and Mounawer Badri Tags: Research Source Type: research
Efficacy of powdered alfalfa leaves to ameliorate the toxic effects of aflatoxin B1 in turkey poults
AbstractThis experiment was conducted to determine the effect of an adsorbent material based on powdered alfalfa leaves added in the aflatoxin B1 (AFB1)-contaminated diet of turkey poults on production parameters, blood cell count, serum biochemistry, liver enzymes, and liver histology. For this purpose, three hundred and fifty female Nicholas-700 poults were randomly assigned into five treatments: (1) Control, AFB1-free diet; (2) AF, diet contaminated with 250 ng AFB1/g; (3) Alfalfa, AFB1-free diet + 0.5% (w/w) adsorbent; (4) AF+alfalfa, diet contaminated with 250 ng AFB1/g + 0.5% (w/w) adsorbent, and (5) AF+...
Source: Mycotoxin Research - February 29, 2024 Category: Toxicology Source Type: research
Amplatzer or Figulla Flex II Occluder: a comparative study of outcomes after transcatheter patent foramen ovale closure
CONCLUSIONS: PFO closure is safe and effective when performed with either the self-expanding Abbott Amplatzer or Occlutech Figulla Flex II PFO occluder.PMID:38412438 | DOI:10.25270/jic/23.00291 (Source: The Journal of Invasive Cardiology)
Source: The Journal of Invasive Cardiology - February 27, 2024 Category: Cardiology Authors: Stefan Toggweiler Federico Moccetti Nina Conrad Lucca Loretz Mehdi Madanchi Matthias Bossard Adrian Attiger-Toller Florim Cuculi Mathias Wolfrum Source Type: research
GSE244008 Biological nitrogen fixation maintains C/N balance and photosynthesis at elevated CO2
Contributor : Matthew D BrooksSeries Type : Expression profiling by high throughput sequencingOrganism : Medicago sativaTo investigate the effect that biological nitrogen fixation will have on plant responses to nitrogen dose at elevated CO2, alfalfa (Medicago sativa) lines were grown at three nitrogen doses and ambient or elevated CO2. Four lines were used in the study, two lines that can form nodules capable of fixing nitrogen (effective lines) and two lines that can not form nodules capable of nitrogen fixation (ineffective lines). The ineffective lines are the result of a complementary mutation in the same gene. (Sour...
Source: GEO: Gene Expression Omnibus - February 26, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Medicago sativa Source Type: research
Genome assembly of Medicago truncatula accession SA27063 provides insight into spring black stem and leaf spot disease resistance
Medicago truncatula, model legume and alfalfa relative, has served as an essential resource for advancing our understanding of legume physiology, functional genetics, and crop improvement traits. Necrotrophic fun... (Source: BMC Genomics)
Source: BMC Genomics - February 23, 2024 Category: Genetics & Stem Cells Authors: Jacob R. Botkin, Andrew D. Farmer, Nevin D. Young and Shaun J. Curtin Tags: Research Source Type: research
Microbiological and metabolic pathways analysing the mechanisms of alfalfa polysaccharide and sulfated alfalfa polysaccharide in alleviating obesity
This study aimed to analyze the mechanism of action of AP and SAP in alleviating obesity through combined microbiomics and metabolomics. The research selected validated optimal AP and SAP concentration for experiment. The results showed that AP and SAP down-regulated colonic inflammatory gene expression, regulated intestinal pH to normal, and restored intestinal growth. Microbial sequencing showed that AP and SAP altered the microbial composition ratio. AP increased the relative abundance of Muribaculaceae and Romboutsia. SAP increased the relative abundance of Dubosiella, Fecalibaculum and Desulfovibrionaceae. Metabolomic...
Source: International Journal of Biological Macromolecules - February 22, 2024 Category: Biochemistry Authors: Zhiwei Li Ruxue Sang Guilan Feng Yuxi Feng Ran Zhang Xuebing Yan Source Type: research
Synergistic effect of pyrene and heavy metals (Zn, Pb, and Cd) on phytoremediation potential of Medicago sativa L. (alfalfa) in multi-contaminated soil
Environ Sci Pollut Res Int. 2024 Feb 21. doi: 10.1007/s11356-024-32499-4. Online ahead of print.ABSTRACTThe environment in India is contaminated with polycyclic aromatic hydrocarbons (PAHs) due to the occurrence of large anthropogenic activities, i.e., fuel combustion, mineral roasting, and biomass burning. Hence, 13 toxic PAHs were detected: phenanthrene, anthracene, fluoranthene, pyrene, and benz(a) anthracene, ben-zo; (b) fluoranthene, benzo(k) fluoranthene, benzo(a) pyrene, benzo(ghi)perylene, dibenz (ah) anthracene, indeno1,2,3-(cd) pyrene, coronene and coronene in the environment (i.e., ambient particulate matter, ro...
Source: Environmental Science and Pollution Research International - February 22, 2024 Category: Environmental Health Authors: Jyoti Mathur Ritu Panwar Source Type: research
