Lipid Metabolism in Age-Related Disease
In this age of excess calories, in which a large proportion of the population is significantly overweight, research into lipid metabolism in the context of aging tends overlap with research into lipid metabolism in the context of obesity. People of normal weight still undergo complex changes in lipid metabolism and lipid transport throughout the body with age, however. These lead to prominent, important issues such as atherosclerosis, localized excesses of cholesterol and associated lesions in the arterial walls, for example. Looking at these conditions through the lens of lipid metabolism is looking at just one part of a ...
Source: Fight Aging! - August 23, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Academics Weigh In On How To Bring Down Trump
By MIKE MAGEE
This week, as a fourth indictment came due, a tragic Donald Trump headed back to social media, digging himself into a hole that will eventually lead to some personal hell. But before Donald Trump, there was William Frederick Kohler.
He made his appearance on the American stage on February 28, 1995, an historian who had just completed his “Great Work” – The Guilt and Innocence of Hitler’s Germany. He was odd and dark and duplicitous. His life’s work was ready to go. All that was left was to write the introduction to his book. Instead his attention was diverted, as he followed his impulse to...
Source: The Health Care Blog - August 18, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Mike Magee Trump Source Type: blogs
“I Saw Guns and Sharp Swords in the Hands of Young Children”: Why Mental Health Courts for Juveniles with Autism Spectrum Disorder and Fetal Alcohol Spectrum/Disorder Are Needed
Michael L. Perlin (New York Law School), Heather Cucolo (New York Law School), Deborah Dorfman (Disability Rights Connecticut), “I Saw Guns and Sharp Swords in the Hands of Young Children”: Why Mental Health Courts for Juveniles with Autism Spectrum Disorder... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - August 15, 2023 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
The Popular Drink Linked To Cognitive Decline — Yet Again
While the drink used to be thought safe for brain health, the latest research finds otherwise. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - August 14, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Alcohol Dementia Source Type: blogs
Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health."
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Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis?
https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/
Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't ...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Stimulating the Olfactory System as a Way to Improve Late Life Cognitive Function
The research noted here adds to evidence for the lack of use of the senses to contribute to age-related declines in cognitive function: a sort of "use it or lose it" proposition for the brain that becomes especially pronounced in later life. This effect is better studied in the context of age-related deafness, given the sizable amount of data on hearing aid use. Here, however, researchers focus on the sense of smell, and find that cognitive function can be improved by stimulation via scents.
When a fragrance wafted through the bedrooms of older adults for two hours every night for six months, memories skyrocketed....
Source: Fight Aging! - August 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Elderly, Constipation, And Hypertension: Unraveling The Surprising Connection From A Recent Study
Conclusion
As we’ve delved into the intricate web linking constipation and hypertension, one thing becomes crystal clear: the world of medicine is vast, and understanding even commonplace issues like constipation can unlock deeper insights into more pressing concerns like cardiovascular diseases. This La Trobe University study shines a spotlight on the urgency of recognizing and effectively addressing non-traditional risk factors.
For our readers, especially those gracefully journeying into their 60s and beyond, let this be a gentle nudge. Your health is a mosaic of interconnected pieces. Something as seemingly...
Source: The EMT Spot - August 6, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Study Warns That Even Light Drinking Can Raise Blood Pressure
Conclusion
In sum, the international research study underscores the significant impact of alcohol consumption on blood pressure, with effects noticed even at low levels. Contrary to common assumptions, it highlights no beneficial effects in low-level drinkers compared to non-drinkers.
The findings serve as a crucial reminder of the importance of moderation, or ideally, avoidance of alcohol for effective blood pressure management and optimal cardiovascular health. The global scale and comprehensive approach of the study lend weight to its findings, making them a key resource for individuals worldwide.
In the face o...
Source: The EMT Spot - August 1, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Isometric Exercises: A New Hope For Hypertension Management
Conclusion
As we reflect on the power of exercise in managing hypertension, it’s clear that isometric workouts stand as a compelling addition to the traditional regimen.
Their role in significantly reducing both systolic and diastolic blood pressure, as the study suggests, offers fresh hope for individuals navigating the challenges of high blood pressure.
Yet, as we embrace these workouts, it’s essential to remember the words of healthcare professionals like Joanne Whitmore and Jim Pate. Exercise, though pivotal, is just one aspect of a broader strategy to manage hypertension.
Alongside this, life...
Source: The EMT Spot - July 31, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity.
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Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Repair Biotechnologies View of Cholesterol Pathology at the 2023 Foresight Longevity Workshop
I attended the Foresight Institute's 2023 Longevity Frontiers Workshop earlier in the year. This event series provides a chance to make connections with some of the longevity industry figures and academic researchers in the field of aging that are associated with the Bay Area venture and futurist communities. The format this year was rapid-fire seven minute presentations and longer discussions; the presentations are shared online. I presented an informal, abbreviated version of the Repair Biotechnologies viewpoint on the role of cholesterol in aging and disease, trying to cover at least the important points in the time all...
Source: Fight Aging! - July 27, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Vasodilators For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
In summary, vasodilators play a pivotal role in managing cardiovascular conditions, including hypertension, which is rapidly becoming a global health concern.
By expanding the body’s blood vessels, these unique medications can improve blood flow and decrease the pressure exerted by the heart, thereby providing relief to numerous patients worldwide.
Their applications are diverse, extending beyond hypertension to conditions like angina, heart failure, and even erectile dysfunction.
However, these medications should be taken carefully and always under the supervision of a doctor due to the potent...
Source: The EMT Spot - July 27, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Central Agonists For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
In summary, central agonists, a notable class of hypertension medications, offer an alternative modality when other first-line antihypertensive treatments fail to show desired results or cause intolerable side effects.
They operate via a unique neurocentric mechanism that primarily functions centrally in the brain, impacting blood pressure regulation by decreasing systemic arterial pressure and heart rate.
Despite their potential side effects and potential for interactions with other drugs, their therapeutic utility in the context of hypertension management remains undiminished.
Moreover, certain cen...
Source: The EMT Spot - July 27, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Mitochondrial Copy Number in Immune Cells Strongly Correlates with 15-Year Mortality
We examined a random population sample in 2003/2005 (n = 9,360, age 45-69, the HAPIEE project) and followed up for 15 years. Using a nested case-control design, we selected non-external deaths among those free from baseline cardiovascular diseases (CVD) and cancer (n = 371), and a sex- and age-stratified control (n = 785). The odds ratios (ORs) of death were 1.06 per one-decile decrease in mtDNA-CN independent of age, sex, metabolic factors, smoking, alcohol intake, and education.
The age-sex-adjusted ORs of death in the second and first tertiles of mtDNA-CN vs. the top tertile were 2.35 and 1.59; an increased risk ...
Source: Fight Aging! - July 25, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Consciously Exploring Your Relationship with Drugs
Humanity has a complex, long-term relationship with a wide variety of drugs. In this article let’s delve into your personal relationship with drugs, how you frame them, and how you might upgrade these relationships to be more conscious and aligned with your path of self-development. Let’s include common drug sources like coffee, tea, and chocolate too, so this will be very inclusive.
My purpose here isn’t to encourage or discourage you from using any particular substances but rather to invite you to take a more conscious and honest look at your current frames, attitudes, biases, and behaviors, and dete...
Source: Steve Pavlina's Personal Development Blog - July 21, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Emotions Health Lifestyle Relationships Values Source Type: blogs
