“When Blood Breaks Down”: It Can Break Your Heart
By CHADI NABHAN, MD, MBA, FACP
“The goal for me and for my clinical and research colleagues is to put ourselves out of a job as quickly as possible”. This is how Mikkael Sekeres ends his book “When Blood Breaks Down” based on true stories of patients with leukemia. I share Mikkael’s sentiments and have always stated that I’d be happy if I am out of a job caring for patients with cancer. To his and my disappointment, this wish is unlikely to ever come true, especially when dealing with leukemia.
With almost 15 years of experience, Sekeres possesses a wealth of knowledge and patient stories making him t...
Source: The Health Care Blog - July 2, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Book Review Chadi Nabhan hematology Mikkael Sekeres Oncology When Blood Breaks Down Source Type: blogs
Is Family Presence Safe During the COVID-19 Pandemic?
by Stephen P. Wood, MS, ACNP-BC
I stood facing the iPad attached to a rolling stand punching in the phone number of the young granddaughter of my intensive care unit patient. He arrived less than twenty-four hours before. I had taken the call the day before from the outside hospital emergency department and the story was grim. This was a seventy-six-year-old male who had acute myeloid leukemia, hypertension, as well as a history of congestive heart failure. He had been sick for the past two days with a fever, a cough and weakness.… (Source: blog.bioethics.net)
Source: blog.bioethics.net - June 1, 2020 Category: Medical Ethics Authors: Blog Editor Tags: End of Life Care Featured Posts Health Care Public Health #bioethicsontheground #covid19 #diaryofaplagueyear COVID-19 Source Type: blogs
Fight Aging! Newsletter, April 6th 2020
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted.
Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - April 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, March 23rd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - March 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Two Way Relationship Between Cellular Senescence and Cancer in Bone Marrow
Cells become senescent in response to a variety of circumstances. The vast majority are cases of replicative senescence, somatic cells reaching the Hayflick limit. Cell damage and toxic environments also produce senescence, and senescent cells are also created as a part of the wound healing process. A senescent cell ceases replication and begins to secrete inflammatory and pro-growth signals, altering the nearby extracellular matrix and behavior of surrounding cells - even encouraging them to become senescent as well.
Near all senescent cells last a short time only, as they self-destruct or are removed by the immune...
Source: Fight Aging! - March 20, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 6th 2020
Conclusion
A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - January 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2019: Progress Towards the Treatment of Aging as a Medical Condition
Conclusion
A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - December 31, 2019 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Fight Aging! Newsletter, December 23rd 2019
In this study, by adenovirus-mediated delivery and inducible transgenic mouse models, we demonstrate the proliferation of both HCs and SCs by combined Notch1 and Myc activation in in vitro and in vivo inner ear adult mouse models. These proliferating mature SCs and HCs maintain their respective identities. Moreover, when presented with HC induction signals, reprogrammed adult SCs transdifferentiate into HC-like cells both in vitro and in vivo. Finally, our data suggest that regenerated HC-like cells likely possess functional transduction channels and are able to form connections with adult auditory neurons.
Epige...
Source: Fight Aging! - December 22, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Prediction of heart failure in leukemia
Researchers have developed a twenty one point score to predict the development of heart failure in acute leukemia patients treated with anthracyclines [1]. They obtained baseline echocardiographic measurements including left ventricular ejection fraction and global longitudinal strain in 450 acute leukemia patients treated with anthracyclines. A 21 point risk score was generated by evaluating potential risk factors for heart failure using Fine and Gray’s regression analysis.
Six variables were selected based on their statistical significance and clinical relevance (assigned score points for each in brackets):
Age ...
Source: Cardiophile MD - December 22, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardio Oncology Onco Cardiology Source Type: blogs
External Versus Intrinsic Causes of Hematopoietic Stem Cell Aging
Today I'll point out a pair of open access review papers in which the authors discuss mechanisms involved in the age-related declines and detrimental altered behaviors of hematopoietic stem cells. These stem cells are responsible for generating blood and immune cells, and so are of vital importance to the function of the immune system throughout life. One paper focuses on external contributions, those arising from the surrounding environment, while the other looks at damage and change arising from the stem cells themselves.
This encapsulates the divide in thinking about stem cell aging in general. At least some stem...
Source: Fight Aging! - December 17, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
AI Diagnoses Leukemia from Blood Samples as Well as Human Cytologists
A good deal of clinical diagnostics are effectively performed by cytologists who examine cells through a microscope for signs of disease. This is an imperfect, slow process that depends on the training, focus, and attention to detail of the cytologist. Now, researchers at Helmholtz Zentrum München and the University Hospital of LMU Munich in Germany have developed an automated system that points to the reality of cytologists becoming an endangered species.
They taught a computer, running deep learning algorithms, to automatically classify cells within blood samples for signatures of acute myeloid leukemia (AML). This r...
Source: Medgadget - November 15, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Diagnostics Informatics Medicine Oncology Pathology Source Type: blogs
Fight Aging! Newsletter, September 16th 2019
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial.
People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - September 15, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Parental responsibility in medical decisions for children
By Steve Phillips The 2 posts on this blog this week by Neil Skjoldal and Mark McQuain raise issues related to parental decision-making for the medical treatment of their children. Neil raised this issue related to parental refusal of life-saving treatment for acute leukemia and Mark raised it related to parental decisions not to have … Continue reading "Parental responsibility in medical decisions for children" (Source: blog.bioethics.net)
Source: blog.bioethics.net - May 8, 2019 Category: Medical Ethics Authors: Steve Phillips Tags: Health Care bioethics Health Care Practice Medical Decision Making syndicated Source Type: blogs
Parental Rights
By Neil Skjoldal What rights do parents have when it comes to the medical care of their children? This bioethical question has recently arisen in the case of Noah McAdams, a 3-year-old who has been diagnosed with acute lymphoblastic leukemia. According to news reports, the recommended treatment in his case is chemotherapy. His parents decided … Continue reading "Parental Rights" (Source: blog.bioethics.net)
Source: blog.bioethics.net - May 6, 2019 Category: Medical Ethics Authors: Neil Skjoldal Tags: Health Care bioethics syndicated Source Type: blogs
