NIH-FDA Immunology Interest Group Seminar
All immune system cells develop from a common hematopoietic stem cell (HSC) whose differentiation pathway is controlled in part by the activation and repression of lineage specific gene programs. Our laboratory is interested in understanding how these transcriptional programs are wired and how alterations in these pathways lead to disease such as autoimmunity, asthma and acute leukemia. ID2 and ID3 control the development and effector fate of innate lymphoid cells including NK cells, ILCs and NKT cells. Our laboratory has focused on understanding how ID protein expression is regulated in innate lymphoid cells and how the t...
Source: Videocast - All Events - December 12, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Integrative Omics Approaches to Identify New Therapeutic Cancer Targets
CCR Grand Rounds
Kimberly Stegmaier, M.D., Professor of Pediatrics at Harvard Medical School and the Ted Williams Chair at Dana-Farber Cancer Institute, has advanced the application of genomics to drug and protein target discovery for pediatric cancers. She is the Vice Chair for Pediatric Oncology Research, co-director of the Pediatric Hematologic Malignancy Program and an attending physician providing clinical care in Pediatric Oncology at the Dana-Farber Cancer Institute and Boston Children ’ s Hospital. Dr. Stegmaier is also an Institute Member of the Broad Institute of Harvard and MIT. She has served as a Council Mem...
Source: Videocast - All Events - June 17, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Daniel J. DeAngelo, MD, PhD - Redefining Patient Care in Acute Lymphoblastic Leukemia: The Impact of Novel Antibody and Immune Technologies on Clinical Outcomes
Redefining Patient Care in Acute Lymphoblastic Leukemia: The Impact of Novel Antibody and Immune Technologies on Clinical Outcomes (Source: Peerview CME/CE Video Podcast - Internal Medicine International)
Source: Peerview CME/CE Video Podcast - Internal Medicine International - January 29, 2018 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
CC Grand Rounds: 1) Developing Multifaceted Cancer Trials: Integrating Laboratory and Clinical Research and 2) Beyond CD19: What is Next for CAR T Cell Therapy in Acute Lymphoblastic Leukemia (ALL)
CC Grand Rounds: 1) Developing Multifaceted Cancer Trials: Integrating Laboratory and Clinical Research and 2) Beyond CD19: What is Next for CAR T Cell Therapy in Acute Lymphoblastic Leukemia (ALL)For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 3/29/2017 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 28, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Daniel J. DeAngelo, MD, PhD - Treatment Evolution in Acute Lymphoblastic Leukemia: Insight on Novel Antibody Technologies and Immunotherapy Advances
Treatment Evolution in Acute Lymphoblastic Leukemia: Insight on Novel Antibody Technologies and Immunotherapy Advances (Source: PeerView CME/CE Video Podcast - Oncology)
Source: PeerView CME/CE Video Podcast - Oncology - January 9, 2017 Category: Cancer & Oncology Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
Secrets and Lyase: New Roles of S1P Signaling in the Immune System
Immunology Interest Group Seminar Series
Sphingosine 1-phosphate (S1P) signaling plays critical roles in the cardiovascular and immune systems. We have recently characterized a mouse that lacks the S1P transporter SPNS2. SPNS2-deficient mice have only a minor reduction in blood S1P and hence grossly normal vascular permeability, but a dramatic reduction in lymph S1P and hence severely disrupted lymphocyte trafficking. These mice have revealed unexpected functions of S1P gradients in positioning immune cells within lymphoid organs, as well as in supporting lymphocyte survival.
Dr. Susan Schwab is Associate Professor at the ...
Source: Videocast - All Events - December 8, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
The Role of RNA Editing in Malignant Reprogramming
NCI’s Center for Cancer Research (CCR) Grand Rounds
Dr. Catriona Jamieson, M.D., Ph.D., is Associate Professor of Medicine, Chief of the Division of Regenerative Medicine, Co-Leader of the Hematologic Malignancies Program in the Division of Hematology-Oncology and Director of Stem Cell Research at the Moores UC San Diego Cancer Center. Dr. Jamieson specializes in myeloproliferative neoplasms (MPNs) and leukemia. Myeloproliferative neoplasms are a family of clonal bone marrow disorders in which the body overproduces blood cells. Myeloproliferative neoplasms can cause many forms of blood clotting including heart attack...
Source: Videocast - All Events - April 4, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
The AML genome(s): Mutations in four dimensions
NIH Director’s Wednesday Afternoon Lecture Series
For many years, Dr. Ley's laboratory has used mouse models of acute myeloid leukemia (AML) to establish key principles of AML pathogenesis. The lab established that the initiating event for Acute Promyelocytic Leukemia is the PML-RARA fusion gene created by the t(15;17) that is found in nearly all patients with this disease. The roles of cooperating mutations and the cellular milieu for APL pathogenesis have also been established. In collaboration with the Genome Institute at Washington University, the investigators of the Genomics of AML PPG (TJ Ley, PI) sequenced the f...
Source: Videocast - All Events - September 1, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Farhad Ravandi, MD - New Territory in Acute Leukemia: How Cutting-Edge Science and Novel Therapies Will Change Patient Care
New Territory in Acute Leukemia: How Cutting-Edge Science and Novel Therapies Will Change Patient Care (Source: Peerview CME/CE Video Podcast - Internal Medicine International)
Source: Peerview CME/CE Video Podcast - Internal Medicine International - February 4, 2015 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
CC Grand Rounds: (1) Measurable Residual Disease in Acute Myeloid Leukemia and (2) Rare Disorders Informing Cancer Biology: Lessons Learned From Dyskeratosis Congenita
Presented by: (1) Christopher Hourigan, MD, DPhil, Assistant Clinical Investigator, Myeloid Malignancies Section, Hematology Branch, NHLBI, NIH and (2) Sharon A. Savage, MD, Senior Investigator and Chief, Clinical Genetics Branch, Division of Cancer Epidemiology aCategory: Clinical Center Grand RoundsAired date: 12/03/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - December 4, 2014 Category: Journals (General) Tags: Past Events Source Type: video
CC Grand Rounds: (1) Measurable Residual Disease in Acute Myeloid Leukemia and (2) Rare Disorders Informing Cancer Biology: Lessons Learned From Dyskeratosis Congenita
For more information go to http://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 10/22/2014 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 23, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Farhad Ravandi, MD - Clinical Trends in Acute Leukemia: New Standards and the Potential of Novel Therapy
Clinical Trends in Acute Leukemia: New Standards and the Potential of Novel Therapy (Source: PeerView CME/CE Video Podcast - Oncology)
Source: PeerView CME/CE Video Podcast - Oncology - October 7, 2013 Category: Cancer & Oncology Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
