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Inhibition of protein Kinase C- α and activation of ezrin by Lactobacillus acidophilus restore Na + /H + exchange activity and fluid absorption in db/db mice
In this study, we investigated whether NHE3 expression is altered in type 2 diabetic intestine and the underlying mechanism that dysregulates NHE3. NHE3 expression in the brush border membrane (BBM) of the intestine of diabetic mice and humans was decreased. Protein kinase C (PKC) activation is associated with pathologies of diabetes and immunofluorescence analysis revealed increased BBM PKCα abundance. Inhibition of PKCα increased NHE3 BBM abundance and NHE3-mediated intestinal fluid absorption in db/db mice. Previous studies have shown that Lactobacillus acidophilus (LA) stimulates intestinal ion transporters. LA incre...
Source: American Journal of Physiology. Endocrinology and Metabolism - July 19, 2023 Category: Physiology Authors: Yiran Han Shanthi Srinivasan C Chris Yun Source Type: research

Inhibition of protein Kinase C- α and activation of ezrin by Lactobacillus acidophilus restore Na + /H + exchange activity and fluid absorption in db/db mice
In this study, we investigated whether NHE3 expression is altered in type 2 diabetic intestine and the underlying mechanism that dysregulates NHE3. NHE3 expression in the brush border membrane (BBM) of the intestine of diabetic mice and humans was decreased. Protein kinase C (PKC) activation is associated with pathologies of diabetes and immunofluorescence analysis revealed increased BBM PKCα abundance. Inhibition of PKCα increased NHE3 BBM abundance and NHE3-mediated intestinal fluid absorption in db/db mice. Previous studies have shown that Lactobacillus acidophilus (LA) stimulates intestinal ion transporters. LA incre...
Source: Am J Physiol Endocri... - July 19, 2023 Category: Endocrinology Authors: Yiran Han Shanthi Srinivasan C Chris Yun Source Type: research

Probiotics treatment ameliorated mycophenolic acid-induced colitis by enhancing intestinal barrier function and improving intestinal microbiota dysbiosis in mice
ConclusionProbiotics treatment ameliorated MPA-induced colitis by enhancing intestinal barrier function and improving intestinal microbiota dysbiosis. Clostridiales might be the dominant functional intestinal microflora and serve as the potential therapy target in MPA-induced colitis. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - July 18, 2023 Category: Microbiology Source Type: research

Comparing the therapeutic potentials of Lactobacillus johnsonii vs. Lactobacillus acidophilus against vulvovaginal candidiasis in female rats: an in vivo study
ConclusionThrough maintaining an immune tolerant state in the vaginal epithelium and ameliorating the undesirable uncontrolled inflammatory response in the vaginal tissue, L. johnsonii (B-2178) has the potential to be utilized alone or in combination with other lactobacilli species in probiotic clinical trials to treat or prevent VVC. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - July 17, 2023 Category: Microbiology Source Type: research

Isolation and characterization of the lactobacillus strain from honey and its probiotic properties
CONCLUSION: Various factors, such as climatic conditions and geographical location, can influence honey's composition and microbial diversity. Identifying and isolating potential probiotic species in honey could significantly expand their use in the food and pharmaceutical industries, offering numerous health benefits and potential therapeutic applications.PMID:37448675 | PMC:PMC10336281 | DOI:10.18502/ijm.v15i3.12905 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - July 14, 2023 Category: Microbiology Authors: Mohammad Ebrahim Goli Mehdi Abadi Ahmad Hosseini-Safa Sina Habibi Mohammadreza Dehghan Mohamad Javad Forouzani-Moghaddam Mojgan Oshaghi Source Type: research