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Probiotics Improve Cognitive Impairment by Decreasing Bacteria-Related Pattern Recognition Receptor-Mediated Inflammation in the Gut-Brain Axis of Mice
CONCLUSIONS: These findings suggest that probiotics may have therapeutic potential for the treatment of inflammation in the gut-brain axis and for cognitive impairment. The mechanism of action of probiotics appears to be related to inhibition of the caspase-11/caspase-1 pathway and reduction of ALPK1 expression.PMID:37519163 | DOI:10.31083/j.jin2204092 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - July 31, 2023 Category: Neuroscience Authors: Xue-Qin Yang Yang Zhao Li Xue Hui-Shan Wang Jia Zeng Jun-Rong Du Zhe Xu Source Type: research

Molecules, Vol. 28, Pages 5732: Improved Viability of Probiotics via Microencapsulation in Whey-Protein-Isolate-Octenyl-Succinic-Anhydride-Starch-Complex Coacervates
Bao Yongjun Yuan The aim of this study was to microencapsulate probiotic bacteria (Lactobacillus acidophilus 11073) using whey-protein-isolate (WPI)&ndash;octenyl-succinic-anhydride-starch (OSA-starch)-complex coacervates and to investigate the effects on probiotic bacterial viability during spray drying, simulated gastrointestinal digestion, thermal treatment and long-term storage. The optimum mixing ratio and pH for the preparation of WPI-OSA-starch-complex coacervates were determined to be 2:1 and 4.0, respectively. The combination of WPI and OSA starch under these conditions produced microcapsules with s...
Source: Molecules - July 28, 2023 Category: Chemistry Authors: Qingqing Liu Chutian Lin Xue Yang Shuwen Wang Yunting Yang Yanting Liu Mingming Xiong Yisha Xie Qingbin Bao Yongjun Yuan Tags: Article Source Type: research

Rapid-dissolving electrospun nanofibers for intra-vaginal antibiotic or probiotic delivery
This study developed a new, rapid-dissolving form using electrospun polyethylene oxide (PEO) fibers for delivery of antibiotic metronidazole or probiotic Lactobacillus acidophilus, and performed evaluation in vitro and in vivo. Fibers did not generate overt pathophysiology or encourage Gardnerella growth in a mouse vaginal colonization model, inducing no alterations in vaginal mucosa at 24 hr post-administration. PEO-fibers incorporating metronidazole (100 µg MET/mg polymer) effectively prevented and treated Gardnerella infections (∼3- and 2.5-log reduction, respectively, 24 hr post treatment) when administered vaginall...
Source: European Journal of Pharmaceutics and Biopharmaceutics - July 21, 2023 Category: Drugs & Pharmacology Authors: Farnaz Minooei Nicole M Gilbert Longyun Zhang Mary Sarah NeCamp Mohamed Y Mahmoud Anthony J Kyser Kevin M Tyo Walter H Watson Ruta Patwardhan Warren G Lewis Hermann B Frieboes Amanda L Lewis Jill M Steinbach-Rankins Source Type: research

Effects of synbiotic supplementation on intestinal microbiota composition in children and adolescents with exogenous obesity: (Probesity-2 trial)
ConclusionThis study is the first pediatric obesity study to show that a synbiotic treatment is associated with both changes intestinal microbiota composition and decreases in BMI. Trial identifier: NCT05162209 (www.clinicaltrials.gov). (Source: Gut Pathogens)
Source: Gut Pathogens - July 21, 2023 Category: Microbiology Source Type: research

Inhibition of protein Kinase C- α and activation of ezrin by Lactobacillus acidophilus restore Na + /H + exchange activity and fluid absorption in db/db mice
In this study, we investigated whether NHE3 expression is altered in type 2 diabetic intestine and the underlying mechanism that dysregulates NHE3. NHE3 expression in the brush border membrane (BBM) of the intestine of diabetic mice and humans was decreased. Protein kinase C (PKC) activation is associated with pathologies of diabetes and immunofluorescence analysis revealed increased BBM PKCα abundance. Inhibition of PKCα increased NHE3 BBM abundance and NHE3-mediated intestinal fluid absorption in db/db mice. Previous studies have shown that Lactobacillus acidophilus (LA) stimulates intestinal ion transporters. LA incre...
Source: American Journal of Physiology. Endocrinology and Metabolism - July 19, 2023 Category: Physiology Authors: Yiran Han Shanthi Srinivasan C Chris Yun Source Type: research

Inhibition of protein Kinase C- α and activation of ezrin by Lactobacillus acidophilus restore Na + /H + exchange activity and fluid absorption in db/db mice
In this study, we investigated whether NHE3 expression is altered in type 2 diabetic intestine and the underlying mechanism that dysregulates NHE3. NHE3 expression in the brush border membrane (BBM) of the intestine of diabetic mice and humans was decreased. Protein kinase C (PKC) activation is associated with pathologies of diabetes and immunofluorescence analysis revealed increased BBM PKCα abundance. Inhibition of PKCα increased NHE3 BBM abundance and NHE3-mediated intestinal fluid absorption in db/db mice. Previous studies have shown that Lactobacillus acidophilus (LA) stimulates intestinal ion transporters. LA incre...
Source: Am J Physiol Endocri... - July 19, 2023 Category: Endocrinology Authors: Yiran Han Shanthi Srinivasan C Chris Yun Source Type: research