Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose
CONCLUSIONS: T-614 is an allosteric inhibitor of MIF that prevented death and decreased hepatic hydrogen peroxide concentrations when given prophylactically in a murine model of acetaminophen overdose. Further studies are needed to elucidate the mechanistic role of MIF in APAP toxicity.PMID:38539088 | DOI:10.1186/s10020-024-00803-0 (Source: Molecular Medicine)
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Joshua Bloom Georgios Pantouris Mingzhu He Bayan Aljabari Lopa Mishra Ramu Manjula Andrew Parkins Elias J Lolis Yousef Al-Abed Source Type: research
Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose
CONCLUSIONS: T-614 is an allosteric inhibitor of MIF that prevented death and decreased hepatic hydrogen peroxide concentrations when given prophylactically in a murine model of acetaminophen overdose. Further studies are needed to elucidate the mechanistic role of MIF in APAP toxicity.PMID:38539088 | PMC:PMC10976746 | DOI:10.1186/s10020-024-00803-0 (Source: Molecular Medicine)
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Joshua Bloom Georgios Pantouris Mingzhu He Bayan Aljabari Lopa Mishra Ramu Manjula Andrew Parkins Elias J Lolis Yousef Al-Abed Source Type: research
Comparative analysis of gene expression between mice and humans in acetaminophen-induced liver injury by integrating bioinformatics analysis
This study aimed to compare gene expres... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Shanmin Zhao, Yan Feng, Jingyuan Zhang, Qianqian Zhang, Junyang Wang and Shufang Cui Tags: Research Source Type: research
50-Year-Old Man With Fevers, Cough, and Night Sweats
A 50-year-old man presented to the emergency department in August with a 1-month history of progressive nonproductive cough, daily fevers, and drenching night sweats. His medical comorbidities included rheumatoid arthritis. Medications at the time of presentation included adalimumab and occasional acetaminophen as needed. He reported social alcohol use and no tobacco or recreational drug use. He endorsed intermittent headaches, mild dyspnea on exertion, several episodes of feeling off balance, and mild difficulties with short-term memory. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 27, 2024 Category: Internal Medicine Authors: Joelle N. Friesen, Alexandra Allman, Omar Abu Saleh Tags: Residents ’ clinic Source Type: research
Sustainable removal of caffeine and acetaminophen from water using biomass waste-derived activated carbon: Synthesis, characterization, and modelling
Chemosphere. 2024 Mar 23:141787. doi: 10.1016/j.chemosphere.2024.141787. Online ahead of print.ABSTRACTThe removal of caffeine (CFN) and acetaminophen (ACT) from water using low-cost activated carbons prepared from artichoke leaves (AAC) and pomegranate peels (PAC) was reported in this paper. These activated carbons were characterized using various analytical techniques. The results showed that AAC and PAC had surface areas of 1203 and 1095 m2 g-1, respectively. The prepared adsorbents were tested for the adsorption of these pharmaceuticals in single and binary solutions. These experiments were performed under different op...
Source: Chemosphere - March 25, 2024 Category: Chemistry Authors: Abir Melliti Manel Touihri Jana Kofro ňová Chiraz Hannachi Lotfi Sellaoui Adrian Bonilla-Petriciolet Radek Vurm Source Type: research
Sustainable removal of caffeine and acetaminophen from water using biomass waste-derived activated carbon: Synthesis, characterization, and modelling
Chemosphere. 2024 Mar 23:141787. doi: 10.1016/j.chemosphere.2024.141787. Online ahead of print.ABSTRACTThe removal of caffeine (CFN) and acetaminophen (ACT) from water using low-cost activated carbons prepared from artichoke leaves (AAC) and pomegranate peels (PAC) was reported in this paper. These activated carbons were characterized using various analytical techniques. The results showed that AAC and PAC had surface areas of 1203 and 1095 m2 g-1, respectively. The prepared adsorbents were tested for the adsorption of these pharmaceuticals in single and binary solutions. These experiments were performed under different op...
Source: Chemosphere - March 25, 2024 Category: Chemistry Authors: Abir Melliti Manel Touihri Jana Kofro ňová Chiraz Hannachi Lotfi Sellaoui Adrian Bonilla-Petriciolet Radek Vurm Source Type: research
Activation of sodium percarbonate by cysteine complexation of Fe(II) for the degradation of acetaminophen in water
New J. Chem., 2024, Advance Article DOI: 10.1039/D3NJ05902B, PaperYingzi Lin, Ningning Sun, Qingyu Zhang, Lei Chen, Shengbo Sun, Hong Yang, Jing Chen, Qixuan Weng, Shuang Xue To overcome the limitations of the Fe(II)-activated percarbonate process for ACT removal, this study introduced cysteine as a complexing agent into the Fe(II)/SPC system and enhanced the degradation efficiency of ACT. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - March 22, 2024 Category: Chemistry Authors: Yingzi Lin Source Type: research
GAS6/TAM Axis as Therapeutic Target in Liver Diseases
In conclusion, the TAM system is becoming an interesting pharmacological target in liver pathology and a focus of future biomedical research in this field. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - March 21, 2024 Category: Gastroenterology Authors: Tutusaus, Anna Morales, Albert Garc ía de Frutos, Pablo Mar í, Montserrat Tags: Review Article Source Type: research
Clinical validation of a fast-acting acetaminophen: a randomized, active and placebo controlled dental pain study
Conclusions: This study supports previous studies, demonstrating faster onset of analgesia with FA-acetaminophen 1000 mg compared to OTC ES-acetaminophen 1000 mg and OTC LG-ibuprofen 400 mg.ClinicalTrials.gov Identifier: NCT03224403 https://clinicaltrials.gov/ct2/show/NCT03224403.PMID:38505928 | DOI:10.1080/03007995.2024.2331159 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2024 Category: Research Authors: Andrew Myers Todd Bertoch Paul Zhang Stephen A Cooper Source Type: research
The effect of oral analgesic premedication on the success rate of inferior alveolar nerve block for teeth with irreversible pulpitis: A randomized clinical trial
Conclusions: Premedication with Pharmapain (an anti-inflammatory agent) and dexamethasone (a corticosteroid) does not enhance the success rate of the IANB technique in mandibular molars with irreversible pulpitis compared to placebo. However, the use of dexamethasone was significantly more effective than Pharmapain in reducing pain severity at inserting the first endodontic file. (Source: Journal of Dental Materials and Techniques)
Source: Journal of Dental Materials and Techniques - March 17, 2024 Category: Dentistry Source Type: research
Magnesium hydride protects against acetaminophen-induced acute kidney injury by inhibiting TXNIP/NLRP3/nf- κb pathway
Ren Fail. 2024 Dec;46(1):2330629. doi: 10.1080/0886022X.2024.2330629. Epub 2024 Mar 17.ABSTRACTAcetaminophen (APAP)-induced acute kidney injury (APAP-AKI) has turned into one of reasons for clinic obtained renal insufficiency. Magnesium hydride (MgH2), as a solid-state hydrogen source, might be potentially applied in clinical practice. The current study aimed to investigate the protective effect of MgH2 against APAP-AKI. The results showed that MgH2 improved renal function and histological injury in mice of APAP-AKI. MgH2 also had protective effects on APAP-induced cytotoxicity in HK-2 cells. In addition, the increased lev...
Source: Renal Failure - March 17, 2024 Category: Urology & Nephrology Authors: Yachen Si Lulu Liu Yinyin Zhang Hongxia Li Tingting Zhao Su Liu Xuejun Sun Jin Cheng Hongtao Lu Source Type: research
Magnesium hydride protects against acetaminophen-induced acute kidney injury by inhibiting TXNIP/NLRP3/nf- κb pathway
Ren Fail. 2024 Dec;46(1):2330629. doi: 10.1080/0886022X.2024.2330629. Epub 2024 Mar 17.ABSTRACTAcetaminophen (APAP)-induced acute kidney injury (APAP-AKI) has turned into one of reasons for clinic obtained renal insufficiency. Magnesium hydride (MgH2), as a solid-state hydrogen source, might be potentially applied in clinical practice. The current study aimed to investigate the protective effect of MgH2 against APAP-AKI. The results showed that MgH2 improved renal function and histological injury in mice of APAP-AKI. MgH2 also had protective effects on APAP-induced cytotoxicity in HK-2 cells. In addition, the increased lev...
Source: Renal Failure - March 17, 2024 Category: Urology & Nephrology Authors: Yachen Si Lulu Liu Yinyin Zhang Hongxia Li Tingting Zhao Su Liu Xuejun Sun Jin Cheng Hongtao Lu Source Type: research
