Fight Aging! Newsletter, September 28th 2020
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results.
Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - September 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Theorizing on Cosmic Radiation as an Accelerator of Aging via Cellular Senescence
Researchers here suggest that some of the detrimental effects of prolonged space missions are mediated by an increased burden of senescent cells resulting from cosmic radiation exposure. Senescent cell accumulation is a feature of aging and cancer treatments such as chemotherapy, and contributes to the progression of age-related dysfunction and disease. Senescent cells secrete an inflammatory mix of signal molecules that disrupt nearby tissue structure, alter cell behavior, and rouse the immune system into a state of chronic inflammation. Even a small number of senescent cells can have outsized effects on tissue function d...
Source: Fight Aging! - September 24, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Some Risky Behavior Might Be Necessary for Your Elder ’s Mental Health
Dear Carol: My dad, 72, has been adventurous all his life and that spirit doesn’t seem to be dampened by aging or even some health problems. He’s always loved snow skiing though thankfully he settles for just cross-country skiing on our flat trails. He still wants to ride his bike in all seasons except winter, and that scares me to death. He says this is healthy. Yes, but what if he falls doing these things? How do I convince him that he’s risking life and limb with the way he lives? His brain seems to be working fine so I’m limited in how much I can intervene, but I live in fear that he will have a terrible...
Source: Minding Our Elders - September 20, 2020 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Shorter dream-stage sleep may be related to earlier death
This study showed an association between reduced REM and increased mortality, but it did not demonstrate the cause of the association. REM deprivation could independently contribute to the development of numerous other diseases. The results apply more clearly to older adults, given that the age groups studied averaged in the 50s and 70s. Short REM may also be a marker of a sick or aging brain; less REM sleep has already been tied to a greater risk of dementia. Overall, ensuring adequate REM sleep is important to protecting your long-term health.
Getting better sleep in middle age and beyond
Maintaining good sleep should re...
Source: Harvard Health Blog - September 18, 2020 Category: Consumer Health News Authors: Lawrence Epstein, MD Tags: Brain and cognitive health Fatigue Memory Sleep Source Type: blogs
Is now the time for single payer? [PODCAST]
“Single payer is the solution. And the time for it is now. A single-payer system would guarantee health care coverage immediately to every American. So whether a loved one gets sick from COVID, has a heart attack, or gets in a car accident, she will receive the care she needs without it causing financial hardship. […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 16, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast Public Health & Policy Source Type: blogs
Minneapolis Won ’t Let Riot‐Battered Stores Install Security Shutters
Walter OlsonIn the destructive riots that hit Minneapolis this summer — riots I’ve argued libertariansshould be in the forefront of condemning —nearly 1,500 businesses were heavily damaged or destroyed.For many of these businesses, the Minneapolis city government adds a special insult: itwon ’t let shop owners install exterior shutters to protect against break ‐ins, a common practice in other cities. TheStar ‐Tribune reported on the resulting frustration:In a report justifying the rule change, Minneapolis officials argued that external shutters “cause visual blight” and create the impression that...
Source: Cato-at-liberty - September 15, 2020 Category: American Health Authors: Walter Olson Source Type: blogs
What to do when one size does not fit all
Alert: rant ahead.
Early in my career working in persistent pain management, it was thought that “chronic pain is chronic pain is chronic pain” and pretty much anything that helped one person would help the next. Over time we’ve learned a lot more about persistent pain: the mechanisms differ a lot between neuropathic mechanisms and nociplastic mechanisms. Even within these groups, the mechanisms are very different. We’ve also learned a lot more about the psychosocial variables that are associated with prolonged disability and distress when pain persists. Some of the earliest work by Turk and coll...
Source: HealthSkills Weblog - September 6, 2020 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Groupwork Interdisciplinary teams Pain conditions Research Science in practice Source Type: blogs
Fight Aging! Newsletter, September 7th 2020
In conclusion, using a large cohort with rich health and DNA methylation data, we provide the first comparison of six major epigenetic measures of biological ageing with respect to their associations with leading causes of mortality and disease burden. DNAm GrimAge outperformed the other measures in its associations with disease data and associated clinical traits. This may suggest that predicting mortality, rather than age or homeostatic characteristics, may be more informative for common disease prediction. Thus, proteomic-based methods (as utilised by DNAm GrimAge) using large, physiologically diverse protein sets for p...
Source: Fight Aging! - September 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Good and Bad Nuclear Issues in the 2020 China Military Power Report
ConclusionThe 2020 DoD report on China ’s military power should be applauded for the level of detailed, unclassified information it presents on China’s nuclear forces and approach to deterrence. Understanding China’s nuclear strategy is the first step toward crafting U.S. policies that prevent a nuclear exchange between the two countries as their general relationship sinks deeper into acrimony and the risk of armed conflict increases.While the lower warhead estimate is welcome news, China shifting to a LOW posture would not be in America ’s interest. Military planners in Washington should seriously consid...
Source: Cato-at-liberty - September 2, 2020 Category: American Health Authors: Eric Gomez Source Type: blogs
Fishing Out the Fish Hook
Outdoor recreation has exploded since we all began social distancing for COVID-19, and EDs are seeing more camping and home improvement injuries from table saws, crafting projects, and even canning (burns). Boating and motorcycle accidents also seem to be on the rise. Many fisherfolk will be on and in the water using hooks, barbs, lines, and wires. Many of these anglers will arrive with a hook in the arm, hand, or scalp, unable to remove the hook themselves. In fact, their own attempts to remove the hooks may make matters worse. Fish hook injuries may seem simple at first, but can quickly get complicated, depending on t...
Source: The Procedural Pause - September 1, 2020 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Theophylline Produces Accelerated Remyelination in the Central Nervous System of Mice
The myelin sheathing around axons is necessary for the proper function of nervous system tissue. Demyelinating conditions such as multiple sclerosis, an autoimmune disease in which the immune system attacks myelin, well illustrate the severe consequences that result from a sizable loss of myelin. Unfortunately, the integrity of myelin sheathing declines with age for everyone, most likely the result of disruption and damage in the oligodendrocyte cell population responsible for maintaining these structures. Evidence suggests that this contributes to cognitive decline and other issues. Thus it is worth keeping an eye on prog...
Source: Fight Aging! - September 1, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Imposter Syndrome: Why You Have It & How to Stop It
“I have written eleven books, but each time I think, ‘Uh oh, they’re going to find out now. I’ve run a game on everybody and they’re going to find me out.” – Maya Angelou
Any minute now they would find out.
I scanned the large conference room. The twenty-six project team members around the table discussed data analysis. Their voices were muffled by the thick fog of my anxiety.
My own throat tried to choke me, and my chest refused to expand. Sweat trickled down my side.
Breathe, just breathe. It’s going to be okay.
My eyes met my boss’s and he smiled at me across the room. I quickly looked down...
Source: World of Psychology - August 31, 2020 Category: Psychiatry & Psychology Authors: Psych Central Guest Author Tags: Publishers Tiny Buddha Fraud imposter syndrome self-worth Source Type: blogs
New Cato Book: Ten Global Trends Every Smart Person Should Know: And Many Others You Will Find Interesting
In conclusion, I hope that you will buy this book and share it with your family and friends. It is meant to be a conversation piece. Instead of gathering dust on a bookshelf, it is designed to lie on a living room table (like so many architecture and interior design books), for visitors to see and discuss over a martini or glass of wine. I hope that it will alleviate some depression and anxiety, spark a fact ‐filled discussion around the dining room table, and maybe even change some minds. Strangers things have happened. Cheers! (Source: Cato-at-liberty)
Source: Cato-at-liberty - August 31, 2020 Category: American Health Authors: Marian L. Tupy Source Type: blogs
Podcast: Does Law Enforcement Need Mental Health Care?
Today’s show takes a good hard look at police culture as a whole. What type of personality is drawn to a career in law enforcement? What are officers taught in the academy? Why do they receive so little mental health care when they face so much trauma on the job? These are just a few of the areas that our guest, mental health advocate Gabriel Nathan, lays bare.
Join us as we discuss the basic foundations of law enforcement and how Gabriel believes the profession needs to evolve to keep up with the times.
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Source: World of Psychology - August 27, 2020 Category: Psychiatry & Psychology Authors: The Psych Central Podcast Tags: General Interview Mental Health and Wellness Podcast Policy and Advocacy The Psych Central Show Source Type: blogs
Bottom ’s Up: My Addiction Journey
The West Vancouver (Canada) police officer rang the doorbell of my house on Cypress Creek on a fine Tuesday afternoon in April. He told me that a citizen had seen me driving "wildly" the previous Friday afternoon on the Upper Levels Highway and handed me a letter.
I thought back to that day. It had started with a large goblet of Chardonnay while making the kids' breakfast. I drove them to school, returned to the house and continued with the white wine. Then I got into the cocaine. Then I was too wired to do anything so I popped a Zopiclone, a tiny blue pill that is guaranteed to put me to sleep no matter ...
Source: PickTheBrain | Motivation and Self Improvement - August 26, 2020 Category: Consumer Health News Authors: Rosemary Keevil Tags: depression family featured psychology addiction anxiety grief recovery Source Type: blogs
