Maternal Serum Zinc, Copper, Magnesium, and Iron in Spontaneous Abortions

This study can help in establishing critical cut-offs of these minerals in maternal serum that can forecast future pregnancy outcomes. Study measured the serum Zn, Cu, Mg, and Fe in pregnant women who presented with (n = 80) and without (n = 100) SA at 5–2 weeks of pregnancy using iron -ferrozine method, magnesium-calmagite method, zinc reaction with nitro-PAPS, copper reaction with Di-Br- PAESA methods, respectively. Data analyzed using the student t test and cutoff value was established using Receiver Operating Characteristi c (ROC) by SPSS software. Maternal serum Cu, Mg, Fe, and Zn levels measured were significantly lower in SA as compared to that of controls (p <  0.005) (Fig. 1) and maternal age and Body mass index were not statistically significant different among study group. Maternal serum Cu, Mg, Zn and Iron (Fe) measured in 5 –12 weeks of pregnancy has the potential to forecast future occurrence of SA. The study has been registered under “The Clinical Trials Registry- India (CTRI),” -REF/2020/01/030393.
Source: Indian Journal of Clinical Biochemistry - Category: Biochemistry Source Type: research