Non-controlled and over-the-counter drugs of abuse

  2.5 out of 5 stars Abuse of Medications That Theoretically Are Without Abuse Potential. Reeves RR et al. South Med J 2015 Mar;108:151-157. Abstract This review of noncontrolled prescription and over-the-counter drugs that can be and have been abused for non-medical or recreational purposes is rather sketchy and anecdotal (as the authors admit,) but nevertheless contains some useful information. Classes of drugs discussed include: Cold &Cough products: pseudoephedrine, ephedrine, oxymetazoline, dextromethorphan Anticholinergics: diphenhydramine, benztropine, trihexyphenidyl (Artane) Antipsychotics: quetiapine, olanzapine Antidepressants: tricyclics, bupropion, fluoxetine, venlafaxine Anitconvulsants: pregabalin, gabapentin Muscle relaxants: carisoprodol, cyclobenaprine (Flexeril,) baclofen Among the more interesting take-home lessons from tis paper : bupropion is sometimes abused by nasal insufflation (snorting), thus bypassing first-pass metabolism and enhancing its cocaine-like effect at high doses [as the clip above shows, bupropion is also abused by injection] dextromethorphan in large doses has dissociative and  hallucinogenic effects similar to theses of phencyclidine (PCP) or ketamine gabapentin and quetiapine have been reported to enhance the effects of Suboxone (buprenorphine/naloxone)
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical cough/cold preparations dextromethorphan medication abuse otc over-the-counter Source Type: news

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Introduction Lassa fever (LF) is a severe acute viral hemorrhagic illness caused by a virus belonging to the family Arenaviridae.1,2 The disease was first discovered in Sierra Leone in the 1950s, but the aetiological agent was first isolated after an outbreak of the disease in a village called Lassa in Borno State, Nigeria claiming the lives of two foreign missionary nurses in 1969.3 The virus exhibits persistent, asymptomatic infection, with profuse urinary virus excretion in Mastomys natalensis rodents, which serve as the natural reservoir.1,2 The virus is shed in their excreta (urine and faeces) of the rodent which can...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Button battery ingestion is one of the leading causes of death in paediatric poisoning and this has sharply risen from 2016 despite manufacturing warnings and the addition of tape to cover the negative side (not very useful once you’ve removed that to place it in your device). See Poison.org for more statistics. What makes button battery ingestion more frightening is the fact that the ingestion may go unwitnessed, the child may have vague symptoms like &lsq...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Toxicology and Toxinology button battery tox library toxicology library Source Type: blogs
By SAURABH JHA Of my time arguing with doctors, 30 % is spent convincing British doctors that their American counterparts aren’t idiots, 30 % convincing American doctors that British doctors aren’t idiots, and 40 % convincing both that I’m not an idiot. A British doctor once earnestly asked whether American physicians carry credit card reading machines inside their white coats. Myths about the NHS can be equally comical. British doctors don’t prostate every morning in deference to the NHS, like the citizens of Oceania sang to Big Brother in Orwell’s dystopia. Nor, in their daily rounds, do the...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: OP-ED Uncategorized AlfieEvans Source Type: blogs
If you have mesothelioma and you’ve already received standard-of-care therapies, you may be considering an immunotherapy clinical trial. If you’re considering this option, a free immunotherapy teleconference is a great place to learn more. CancerCare recently hosted two one-hour education workshops featuring panels of immunotherapy experts. Part I of the teleconference presented an overview of immunotherapy. Part II of the teleconference, which is available online for free, focused exclusively on immunotherapy side effects. Understanding these issues and the role each patient plays in managing their own side ef...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Conclusions: We show evidence that acute exposure to elemental mercury can affect the heart rhythm, including a complete atrioventricular blockage.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Case Report Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 231. Readers can subscribe to FFFF RSS or subscribe to the FFFF weekly EMAIL Question 1: You find yourself on holiday in Africa helping out with a dermatology clinic (yes, your forte as an emergency physician). In the queue is a young boy who describes&nb...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Frivolous Friday Five anthrax cholera Dilip Mahalanabis Dr Bayford dysentery dysphagia lusoria ORS saber shins Thomas Hodgkin wool-sorters disease yaws Source Type: blogs
Conclusions The lung-moistening, cough-relieving and phlegm-resolving actions of the root of LP are attributed to the anti-inflammatory properties of flavonoids and terpenoids. The heat-clearing, dampness-removing and gallbladder-normalizing (to cure jaundice) actions of the flowers of LP are based on the anti-inflammatory, antioxidant and hepatoprotective activity properties of terpenoids, flavonoids and sterols. The Traditional Chinese Medicine (TCM) characteristics of LP (bitter flavour) corroborate its potent anti-inflammatory effects. In addition, the remarkable anti-inflammatory and antioxidant capacities of LP contr...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
CONTEXT: Recent restrictions in access to and availability of dextromethorphan (DXM) cough and cold medications may correlate with changes in abuse exposures. OBJECTIVE: To extend and update existing knowledge about DXM abuse, we describe recent tr...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
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Source: Clinical Toxicology - Category: Toxicology Authors: Source Type: research
 is an infection caused by the bacterium Corynebacterium Diphtheriae. Signs and symptoms usually start 2 – 5 days after exposure and range from mild to severe. Symptoms often come on gradually, beginning with a sore throat and fever. In severe cases, the bacteria produces a poison (toxin) that causes a thick grey or white patch at the back of throat. This can block the airway making it hard to b reathe or swallow and also create a barking cough. The neck may swell in part due to enlarged lymph nodes. The poison may also get into the blood stream causing &nb...
Source: WHO Feature Stories - Category: International Medicine & Public Health Tags: diphtheria [subject], corynebacterium diphtheria, Q & A [doctype] Source Type: news
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