Acyclovir Brain Disposition: Interactions with P-gp, Bcrp, Mrp2, and Oat3 at the Blood –Brain Barrier

ConclusionThe present study demonstrated that P-gp, Bcrp, Mrp2, and Oat3 inhibition increased the penetration of acyclovir across the BBB, supporting the hypothesis that these efflux pumps restrict the distribution of acyclovir in the brain.

http://link.springer.com/10.1007/s13318-021-00733-w

Source: European Journal of Drug Metabolism and Pharmacokinetics - February 3, 2022 Category: Drugs & Pharmacology Source Type: research