TRPV1, CGRP and SP in scalp arteries of patients suffering from chronic migraine. Some like it hot! Chronic migraine increases TRPV1 receptors in the scalp

The transient receptor potential vanilloid type-1 receptor (TRPV1) is a non-selective, ligand-gated cation channel expressed in small sensory neurons.1 It responds to noxious heat, protons and capsaicin and it is preferentially expressed in small sensory neurons.2 3 Trigeminal nociceptive neurons contain glutamate, substance P (SP) and calcitonin gene-related peptide (CGRP). TRPV1 receptors evoke CGRP release; inhibition prevents and reverses central sensitisation. BoNT/A has analgesic effects on capsaicin-evoked pain. It is effective in chronic migraine treatment.4 BoNT/A decreases TRPV1-positive neurons in the rat trigeminal ganglion.5 What then is the role in periarterial neurovascular scalp structures in migraine?6 Del Fiacco et al7 did a quantitative study of TRPV1-like, CGRP-like and SP-like immunoreactive (IL) innervation of scalp arterial samples from chronic migraine (CM) patients. Immunoreactivity to TRPV1, CGRP, SP and to the pan-neuronal structural nerve marker protein gene...
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Authors: Tags: Immunology (including allergy), Drugs: CNS (not psychiatric), Headache (including migraine), Pain (neurology), Pain (palliative care), Pain (anaesthesia), Drugs: musculoskeletal and joint diseases Editorial commentaries Source Type: research