Microbiomes in the Intestine of Developing Pigs: Implications for Nutrition and Health

Adv Exp Med Biol. 2022;1354:161-176. doi: 10.1007/978-3-030-85686-1_9.ABSTRACTThe past decade has seen an expansion of studies on the role of gut microbiome in piglet nutrition and health. With the help of culture-independent sequencing techniques, the colonization of gut microbiota and their implication in physiology are being investigated in depth. Immediately after birth, the microbes begin to colonize following an age-dependent trajectory, which can be modified by maternal environment, diet, antibiotics, and fecal microbiota transplantation. The early-life gut microbiome is relatively simple but enriched with huge metabolic potential to utilize milk oligosaccharides and affect the epithelial function. After weaning, the gut microbiome develops towards a gradual adaptation to the introduction of solid food, with an enhanced ability to metabolize amino acids, fibers, and bile acids. Here we summarize the compositional and functional difference of the gut microbiome in the keystone developing phases, with a specific focus on the use of different nutritional approaches based on the phase-specific gut microbiome.PMID:34807442 | DOI:10.1007/978-3-030-85686-1_9

Source: Advances in Experimental Medicine and Biology - November 22, 2021 Category: Research Authors: Chunlong Mu Yu Pi Chuanjian Zhang Weiyun Zhu Source Type: research