SARS-CoV-2-associated cytokine storm during pregnancy as a possible risk factor for neuropsychiatric disorder development in post-pandemic infants

Neuropharmacology. 2021 Oct 16:108841. doi: 10.1016/j.neuropharm.2021.108841. Online ahead of print.ABSTRACTA strong association between perinatal viral infections and neurodevelopmental disorders has been established. Both the direct contact of the virus with the developing brain and the strong maternal immune response originated by viral infections can impair proper neurodevelopment. Coronavirus disease 2019 (COVID-19), caused by the highly-infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently responsible for a large global outbreak and is a major public health issue. While initial studies focused on the viral impact on the respiratory system, increasing evidence suggest that SARS-CoV-2 infects other organs and tissues including the mature brain. While studies continue to determine the neuropathology associated to COVID-19, the consequences of SARS-CoV-2 infection to the developing brain remain largely unexplored. The present review discusses evidence suggesting that SARS-CoV-2 infection may have persistent effects on the course of pregnancy and on brain development. Studies have shown that several proinflammatory mediators which are increased in the SARS-CoV-2-associated cytokine storm, are also modified in other viral infections known to increase the risk of neurodevelopmental disorders. In this sense, further studies should assess the genuine effects of SARS-CoV-2 infection during pregnancy and delivery along with an extended follow-up of ...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research

Related Links:

No abstract available
Source: The Journal of ECT - Category: Psychiatry Tags: Commentaries Source Type: research
Conclusions Our results confirm earlier prospective and retrospective data regarding the efficacy and importance of C/M-ECT as relapse prevention. After treatment discontinuation, close monitoring of early warning signs for relapse is crucial, especially in the first few months. With the COVID-19 pandemic continuing, our data provide an indication of the necessity to ensure adequate care and access to ECT not only for the acutely ill but also for the vulnerable patients who are depending on C/M-ECT.
Source: The Journal of ECT - Category: Psychiatry Tags: Original Studies Source Type: research
No abstract available
Source: The Journal of ECT - Category: Psychiatry Tags: Letters to the Editor Source Type: research
No abstract available
Source: The Journal of ECT - Category: Psychiatry Tags: Letters to the Editor Source Type: research
No abstract available
Source: The Journal of ECT - Category: Psychiatry Tags: Letters to the Editor Source Type: research
Jeffrey A. SingerA Food and Drug Administration Advisory Panel justapproved, narrowly, the Merck antiviral drug Molnupiravir. This is just step one. We now have to wait for the FDA to decide on emergency use authorization.The U.K. approved Molnupiravir on November 4.Merck applied to the FDA for approval on October 11. Vaccines are the best long ‐​term defense against COVID-19, but antivirals are the best first‐​line defense, especially when new variants can develop that escape the immunity provided by vaccines.Rather than wait weeks for the vaccine to take effect, antivirals —like antibiotics—work immed...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
West Virginia's coronavirus czar, West Virginia University's Dr. Clay Marsh, said Tuesday that the emergence of the new omicron variant of Covid-19 underscores the need for everyone to be vaccinated and for the fully vaccinated to get their boosters. In a news conference with Gov. Jim Justice and other state officials, Marsh said there have been no cases of the omicron variant identified yet in West Virginia but that state officials were on alert. There also have been no cases yet identified in…
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news
Neuropharmacology. 2021 Oct 16;201:108841. doi: 10.1016/j.neuropharm.2021.108841. Online ahead of print.ABSTRACTA strong association between perinatal viral infections and neurodevelopmental disorders has been established. Both the direct contact of the virus with the developing brain and the strong maternal immune response originated by viral infections can impair proper neurodevelopment. Coronavirus disease 2019 (COVID-19), caused by the highly-infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently responsible for a large global outbreak and is a major public health issue. While initial stu...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
More News: Autism | Brain | Coronavirus | COVID-19 | Drugs & Pharmacology | International Medicine & Public Health | Neurology | Outbreaks | Pandemics | Perinatology & Neonatology | Pregnancy | Respiratory Medicine | SARS | Schizophrenia | Study