Cancers, Vol. 13, Pages 5078: Recent Advances in the Management of Pediatric Acute Myeloid Leukemia —Report of the Hungarian Pediatric Oncology-Hematology Group

Cancers, Vol. 13, Pages 5078: Recent Advances in the Management of Pediatric Acute Myeloid Leukemia—Report of the Hungarian Pediatric Oncology-Hematology Group Cancers doi: 10.3390/cancers13205078 Authors: Zsuzsanna Gaál Zsuzsanna Jakab Bettina Kárai Anikó Ujfalusi Miklós Petrás Krisztián Kállay Ágnes Kelemen Réka Simon Gergely Kriván Gábor T. Kovács Csongor Kiss István Szegedi Outcome measures of pediatric acute myeloid leukemia (AML) improved considerably between 1990 and 2011 in Hungary. Since 2012, efforts of the Hungarian Pediatric Oncology-Hematology Group (HPOG) included the reduction in the number of treatment centers, contemporary diagnostic procedures, vigorous supportation, enhanced access to hematopoietic stem cell transplantation (HSCT), and to targeted therapies. The major aim of our study was to evaluate AML treatment results of HPOG between 2012 and 2019 with 92 new patients registered (52 males, 40 females, mean age 7.28 years). Two periods were distinguished: 2012–2015 and 2016–2019 (55 and 37 patients, respectively). During these periods, 2 y OS increased from 63.6% to 71.4% (p = 0.057), and the 2 y EFS increased significantly from 56.4% to 68.9% (p = 0.02). HSCT was performed in 37 patients (5 patients received a second HSCT). We demonstrate advances in the diagnosis and treatment of acute promyelocytic leukemia (APL) in two cases. Early diagnosis and follow-up were achieved by multidimensional flow cytometr...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research