Myeloid-derived suppressor cells (MDSCs) in brain cancer: challenges and therapeutic strategies

This study aimed to review MDSC function in brain cancer, as well as possible treatments and related challenges. In brain cancer and glioma, sev eral differences in the context of MDSCs have been reported, including disagreements about the MDSC subtype that has the most inhibitory function in the brain, or inhibitory function of regulatory B cells (Bregs). There are also serious challenges in treating glioma patients. In addition to the cold nature of glioma, there are reports of an increase in MDSCs following conventional chemotherapy treatments. As a result, targeting MDSCs in combination with other therapies, such as ICB, is essential, and recent studies with the combination therapy approach have shown promising therapeutic effects in brain cancer.
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research