Cancers, Vol. 13, Pages 4945: Flow Cytometry Immunophenotyping for Diagnostic Orientation and Classification of Pediatric Cancer Based on the EuroFlow Solid Tumor Orientation Tube (STOT)
Cancers, Vol. 13, Pages 4945: Flow Cytometry Immunophenotyping for Diagnostic Orientation and Classification of Pediatric Cancer Based on the EuroFlow Solid Tumor Orientation Tube (STOT)
Cancers doi: 10.3390/cancers13194945
Authors:
Cristiane de Sá de Sá Ferreira-Facio
Vitor Botafogo
Patrícia Mello Ferrão
Maria Clara Canellas
Cristiane B. Milito
Sérgio Romano
Daiana V. Lopes
Lisandra C. Teixeira
Elen Oliveira
Enrico Bruno-Riscarolli
Fabiana V. Mello
Patrícia F. R. Siqueira
Patrícia Moura
Francisco Nicanor Macedo
Danielle N. Forny
Luíza Simião
Ana Luíza Pureza
Marcelo Gerardin Poirot Land
Carlos Eduardo Pedreira
Jacques J. M. van van Dongen
Alberto Orfao
Elaine Sobral da da Costa
Early diagnosis of pediatric cancer is key for adequate patient management and improved outcome. Although multiparameter flow cytometry (MFC) has proven of great utility in the diagnosis and classification of hematologic malignancies, its application to non-hematopoietic pediatric tumors remains limited. Here we designed and prospectively validated a new single eight-color antibody combination—solid tumor orientation tube, STOT—for diagnostic screening of pediatric cancer by MFC. A total of 476 samples (139 tumor mass, 138 bone marrow, 86 lymph node, 58 peripheral blood, and 55 other body fluid samples) from 296 patients with diagnostic suspicion of pediatric cancer were analyzed by MFC vs. conventional diagnostic procedures. STOT was des...
Source: Cancers - Category: Cancer & Oncology Authors: Cristiane de S á de Sá Ferreira-Facio Vitor Botafogo Patr ícia Mello Ferrão Maria Clara Canellas Cristiane B. Milito S érgio Romano Daiana V. Lopes Lisandra C. Teixeira Elen Oliveira Enrico Bruno-Riscarolli Fabiana V. Mello Patr ícia F. R. Siqueira Tags: Article Source Type: research
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