Central sympathetic nerve activation in subarachnoid hemorrhage

AbstractSubarachnoid hemorrhage (SAH) is a life-threatening condition, and although its two main complications —cerebral vasospasm (CVS)/delayed cerebral ischemia (DCI) and early brain injury (EBI)—have been widely studied, prognosis has not improved over time. The sympathetic nerve (SN) system is important for regulating cardiovascular function and is closely associated with cerebral vessels and the reg ulation of cerebral blood flow and cerebrovascular function; thus, excessive SN activation leads to a rapid breakdown of homeostasis in the brain. In the hyperacute phase, patients with SAH can experience possibly lethal conditions that are thought to be associated with SN activation (catecholamine surge)-related arrhythmia, neurogenic pulmonary edema, and irreversible injury to the hypothalamus and brainstem. Although the role of the SN system in SAH has long been investigated and considerable evidence has been collected, the exact pathophysiology remains undetermined, mainly because the rela tionships between the SN system and SAH are complicated and many SN-modulating factors are involved. Thus, research concerning these relationships needs to explore novel findings that correlate with the relevant concepts based on past reliable evidence. Here, we explore the role of the central SN (C SN) system in SAH pathophysiology and provide a comprehensive review of the functional CSN network; brain injury in hyperacute phase involving the CSN system; pathophysiological overlap ...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: REVIEW Source Type: research