Establishment of a murine model of acute-on-chronic liver failure with multi-organ dysfunction

ConclusionThe CCL4/APAP/LPS (CALPS) model of ACLF mimics the clinical, biochemical, and histological features of ACLF with demonstrable progressive hepatocellular necrosis, liver failure, impaired regeneration, development of portal hypertension, and organ dysfunction in an animal with chronic liver disease.Graphic abstract
Source: Hepatology International - Category: Infectious Diseases Source Type: research