Psyllium: The Gel-Forming Nonfermented Isolated Fiber That Delivers Multiple Fiber-Related Health Benefits
Psyllium is a natural, predominantly soluble isolated fiber that forms a gel when hydrated. The psyllium gel is not fermented and transits the entire gastrointestinal tract intact. In the small intestine, the psyllium gel increases chyme viscosity, which slows the degradation and absorption of nutrients, which significantly improves fasting blood glucose and hemoglobin A1c levels in individuals with metabolic syndrome and type 2 diabetes mellitus (eg, −37 mg/dL). This delay in nutrient absorption prolongs satiety/delays hunger, leading to decreased energy intake and weight loss in overweight and obese patients. In the distal small intestine (terminal ileum), psyllium becomes more concentrated as water is absorbed, and the highly viscous gel interferes with the active reuptake of bile acids, which are captured in the gel and eliminated via stool. This decrease in the bile acid pool stimulates the liver to produce more bile. As cholesterol is a component of bile, the liver expresses low-density lipoprotein (LDL) cholesterol receptors to harvest LDL-cholesterol from the blood, thereby lowering both LDL-cholesterol (up to 24%) and total cholesterol (up to 20%) levels without affecting high-density lipoprotein cholesterol level. The cholesterol-lowering benefit of psyllium is also additive to the effects of statin drugs, with an effect equivalent to doubling the statin dose. In the large intestine, the nonfermented psyllium gel has a paradoxical “stool normalizing&rdqu...
European Journal of Clinical Nutrition, Published online: 22 January 2022; doi:10.1038/s41430-021-01051-9Diets for inflammatory bowel disease: What do we know so far?
ConclusionOur data emphasize that metabolic dysfunction has a significant impact on hepatocarcinogenesis in patients with NAFLD. Moreover, coexisting multiple metabolic risk factors would dampen the risk of developing HCC in patients with NAFLD. Closely tracing HCC formation through laboratory examination or imaging is crucial in these patients.
AbstractBackgroundHorseshoe fistula is a challenging benign anorectal condition to treat. The aim of this study was to assess the utilization and success of different definitive fistula repair techniques in the treatment of horseshoe fistula.MethodsThis was a retrospective case series which included all patients who were treated for horseshoe fistula from 2006 to 2019 at a single, tertiary care center and whom had at least one follow-up visit. Patients were excluded if 80% of patients. However, repair can often require multiple surgical procedures.
FRIDAY, Jan. 21, 2022 -- Patients aged younger than 18 years with diagnosed COVID-19 have an increased risk for newly diagnosed diabetes>30 days after acute infection, according to research published in the Jan. 14 issue of the U.S. Centers for...
HIGH cholesterol is often caused by eating fatty food or being overweight. It occurs when you have too much of a fatty substance called cholesterol in your blood. Fortunately, many people can lower their cholesterol by making lifestyle changes.
Elevated blood markers for neurodegeneration can better predict risk of dementia when markers for cerebrovascular disease are also elevated. A link between vascular health and mental health has been found.First Look
Chronic inflammatory signaling is an important issue in aging, both generally throughout the body, and in localized hot spots such as atherosclerotic lesions in blood vessel walls. Macrophage cells responsible for clearing out molecular waste and repairing damage in blood vessels are made less effective by inflammatory signaling. The feedback loop of ineffective macrophages becoming incapacitated by the toxic lesion environment, while inflammation draws in more macrophages, is at the center of the progression of atherosclerosis. Ultimately these fatty lesions grow to the point of rupture, and the result is a heart attack o...
Among US patients hospitalized for diabetic ketoacidosis (DKA), those with obesity hypoventilation syndrome had a higher risk of in-hospital mortality and other adverse outcomes.First Look
About 70% of new fathers in the United States are overweight or obese, while one in five is a smoker, according to the results of a national survey published Friday by the journal PLOS One.
Bariatric surgery is often the treatment of last resort, but considering it earlier may be just what patients with fatty liver disease need.Medscape Gastroenterology
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