Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics

Oral Oncol. 2021 Jul 27;121:105451. doi: 10.1016/j.oraloncology.2021.105451. Online ahead of print.ABSTRACTOral cavity squamous cell carcinoma (OCSCC) is the most common malignancy of the oral cavity. The substantial risk factors for OCSCC are the consumption of tobacco products, alcohol, betel quid, areca nut, and genetic alteration. However, technological advancements have occurred in treatment, but the survival decreases with late diagnosis; therefore, new methods are continuously being investigated for treatment. In addition, the rate of secondary tumor formation is 3-7% yearly, which is incomparable to other malignancies and can lead to the disease reoccurrence. Oral cavity cancer (OCC) arises from genetic alterations, and a complete understanding of the molecular mechanism involved in OCC is essential to develop targeted treatments. This review aims to update the researcher on oral cavity cancer, risk factors, genetic alterations, molecular mechanism, classification, diagnostic approaches, and treatment.PMID:34329869 | DOI:10.1016/j.oraloncology.2021.105451

Source: Cell Research - July 30, 2021 Category: Cytology Authors: Ambika Chamoli Abhishek S Gosavi Urjita P Shirwadkar Khushal V Wangdale Santosh Kumar Behera Nawneet Kumar Kurrey Kiran Kalia Amit Mandoli Source Type: research