New Drug Combination Shows Promise for Peritoneal Mesothelioma

Researchers at MD Anderson Cancer Center in Houston have uncovered a new, promising treatment option for patients with peritoneal mesothelioma, potentially filling a gaping void that exists today. The immunotherapy drug combination of Tecentriq and Avastin, known generically as atezolizumab and bevacizumab, respectively, showed unusual efficacy in a recent study of 20 patients with this rare cancer. Although some patients have previously found significant success and extended survival with the cytoreductive surgery and hyperthermic intraperitoneal chemotherapy combination, or HIPEC, those with unresectable disease have been left with no good options. Until now, possibly. The unique synergy between the study’s two drugs produced a safe and durable response with mesothelioma patients regardless of tumor mutational burden or biomarkers previously thought to predict effectiveness. Cancer Discovery published the study July 14. “The combination of bevacizumab and atezolizumab showed promising tumor shrinkage,” MD Anderson Cancer Center oncologist and lead study author Dr. Kanwal Raghav told The Mesothelioma Center at Asbestos.com. “This combination is a very good and reliable second-line option for patients.” Efficacy of Drug Combination Impresses Researchers According to the study, all participants started second-line treatment after experiencing disease progression following earlier standard chemotherapy, the aggressive surgic...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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ConclusionsIn this study, we showed TEW-7197 and ramucirumab considerably decreased invasiveness, thus EMTness in a panel of diffuse-type GC cell lines including GC PDCs. Taken together, we confirmed that combination of TEW-7197 and ramucirumab reduced tumor spheroid and GC PDC-induced blood vessel formation concomitantly in the spheroid-on-a-chip model.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research
Systematically mapping the mechanical properties of skin and tissue is useful for biomechanics research and disease diagnostics. For example, later stage breast cancer and lymphoma manifest themselves as hard nodes under the skin. Currently, mechanical measurements are done manually, with a sense of touch or a handheld tool. Manual measurements do not provide quantitative information and vary depending on the skill of the practitioner. Research shows that tactile sensors could be more sensitive than a hand. We propose a method that uses our previously developed skin-crawling robots to noninvasively test the mechanical prop...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
New J. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1NJ03533A, PaperLucie Melounkov á, Miriam Syková, Robert Jirásko, Roman Jambor, Radim Havelek, Eva Peterova, Jan Honzicek, Jaromír Vinklárek Two series of heterobimetallic compounds were prepared from the starting complex [cis-L2PtCl2] containing aminophosphine ligand (L = 2,6-iPr2-C6H3-NHPPh2). They cover neutral Pt-Sn complexes [cis-L2PtX(SnCl3)] (X = Cl, SnCl3) and ionic... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Analyst, 2021, Advance Article DOI: 10.1039/D1AN00938A, PaperWei Zhang, Ioannis Karagiannidis, Eliane De Santana Van Vliet, Ruoxin Yao, Ellen J. Beswick, Anhong Zhou Raman spectra acquired from a single living cell were analyzed by a machine learning based algorithm and transformed into aggressiveness score, and further paired with gene expression data for correlation analysis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Overall, cancer responsible for loss of 1.9 percent of total life years expected in the absence of cancer in transplant recipients
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Cardiology, Gastroenterology, Internal Medicine, Nephrology, Oncology, Pulmonology, Surgery, Journal, Source Type: news
Conclusion3D-CT angiography is useful for the preoperative assessment of vascular anatomical variations of the IMV and IMA for safe intraoperative navigation and prevention of complications during laparoscopy-assisted left-sided colorectal surgery.
Source: Surgery Today - Category: Surgery Source Type: research
AbstractThe aim of this study was to systematically review the feasibility and safety of non-operative management of small bowel obstruction (SBO) in virgin abdomen. A systematic review was performed through December 2019. The primary outcome was the resolution of non-operative management of SBO in virgin abdomen. Secondary outcomes were the etiology of SBO and findings of exploratory laparotomy. Six studies were included in the analysis. Of the 442 patients, 2 with metastatic cancer received palliative care, and the management in 26 was not reported, so these patients were excluded. A total of 414 patients were ultimately...
Source: Surgery Today - Category: Surgery Source Type: research
Oncologists are calling for this year's San Antonio Breast Cancer Symposium to be moved out of Texas in response to the state's new abortion law, and a boycott of in-person attendance if no move happens.Medscape Medical News
Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Hematology-Oncology News Source Type: news
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Joe Abdo1, Christopher S. Wichman2, Nicholas E. Dietz1,3, Pawel Ciborowski4, John Fleegel1, Sumeet K. Mittal1,5 and Devendra K. Agrawal1* 1Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, United States 2Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, United States 3Department of Pathology, CHI Health Creighton University Medical Center, College of Medicine, Omaha, NE, United States 4Department of Pharmacology, University of Nebraska Medical Center, Omaha, NE, United States 5Norton Thoracic Institute, St....
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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