Laminin A Peptides

Technology Bundle IDE-246-1988-0 Laminin A PeptidesApplicationsTherapeuticsResearch MaterialsDiagnosticsLinked IDTAB-96Lead InventorsYoshihiko Yamada (NIDCR)Co-InventorsGeorge Martin (NIDCR)Hynda Kleinman (NIDCR)Makoto Sasaki (NIDCR)Therapeutic AreasOncologyICsNIDCRThis invention relates to peptides and derivatives thereof having laminin-like activity, as well as a pharmaceutical composition of the peptide. The peptides claimed include Serine-Isoleucine-Lysine-Valine-Alanine-Valine (SIKVAV). Methods for promoting increased adhesion and migration of epithelial cells is also disclosed. The peptides have wide usage in research, nerve regeneration and cancer treatment. For example, this invention may be useful as an adhesion and regeneration agent for nerve guides and as an adhesion agent for vascular prosthesis. {RefNo is 96 }Commercial Applicationsadhesion agentcancer therapeuticresearch reagentCompetitive Advantageskey extracellular matrix componentwidespread biological activityRequest More InfoLicensing Contact:Vladimir Knezevic, M.D.vlado.knezevic@nih.govPhone: 301.443.5560Intellectual PropertiesEIR ApplicationPCT Application PCT/US89/004871Filed on 1989-11-06US Application 07/530,969Filed on 1990-05-30US Application 08/411,067Filed on 1995-03-27US Pat5,211,657Issued 1993-05-18PublicationsBS Weeks, E Holloway, PE Klotman, SK Akiyama, HW Schnaper, HK Kleinman. 12-O-tetradecanoylphorbol 13-acetate stimulates human T-lymphocyte adherence to the fibronectin RGD domain and the l...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research