DNMT1-mediated methylation of BEX1 regulates stemness and tumorigenicity in liver cancer

Hepatoblastoma (HB) and hepatocellular carcinoma (HCC) exhibit remarkable cancer stem cell (CSCs) features. Moreover, the development of both diseases is closely associated with the presence of CSCs. We investigated the role of brain-expressed X-linked protein 1 (BEX1) in regulating CSC properties of HB, and a subtype of HCC with high CSC features (CSC-HCC).

Source: Journal of Hepatology - July 1, 2021 Category: Gastroenterology Authors: Qian Wang, Ning Liang, Tao Yang, Yuedan Li, Jing Li, Qian Huang, Chen Wu, Ligang Sun, Xile Zhou, Xiaobin Cheng, Long Zhao, Gang Wang, Zhangqian Chen, Xianli He, Chaoxu Liu Source Type: research