The pharmacodynamics of minocycline alone and in combination with rifampicin against Staphylococcus aureus studied in an in vitro pharmacokinetic model of infection

ConclusionsAnfAUC/MIC minocycline target of 12 –36 is appropriate forS. aureus. Addition of rifampicin decreases bacterial load but results in emergence of resistance to rifampicin. Unusually, there was no emergence of resistance to minocycline.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research