Decreased portal circulation augments fibrosis and ductular reaction in nonalcoholic fatty liver disease in mice

Nonalcoholic fatty liver disease (NAFLD) often progresses to cirrhosis and causes liver cancer, but mechanisms of its progression have not been elucidated. Although NAFLD is often associated with abnormal portal circulation, there have not been any experimental studies to test its pathogenic role. Here, we examined whether decreased portal circulation affected the pathology of nonalcoholic steatohepatitis (NASH) using congenital portosystemic shunt (PSS) in C57BL/6J mice. Whereas PSS significantly attenuated free radical-mediated CCl4 injury, it augmented pericellular fibrosis in the centrilobular area induced by a 0.1% methionine choline-deficient L-amino acid-defined high-fat diet (CDAHFD).

Source: American Journal of Pathology - June 10, 2021 Category: Pathology Authors: Lingtong Meng, Masanori Goto, Hiroki Tanaka, Yuki Kamikokura, Yumiko Fujii, Yoko Okada, Hiroyuki Furukawa, Yuji Nishikawa Source Type: research