A prospective, randomized, double-blind trial of intravenous chlorpromazine versus intravenous prochlorperazine for the treatment of acute migraine in adults presenting to the emergency department

CONCLUSIONS: Both chlorpromazine and prochlorperazine are efficacious treatments for acute migraine in adult patients presenting to the ED. This trial found no evidence of superiority of either agent over the other. Caution should be used when prescribing these medicines in the borderline hypotensive patient; in that circumstance, prochlorperazine should be preferentially used.PMID:33797074 | DOI:10.1111/head.14091

Source: Headache - April 2, 2021 Category: Neurology Authors: Sarah E Hodgson Andrew M Harding Elyssia M Bourke David M Taylor Shaun L Greene Source Type: research