Transcriptomic Changes Due to Early, Chronic Intermittent Alcohol Exposure During Forebrain Development Implicate WNT Signaling, Cell-Type Specification and Cortical Regionalization as Primary Determinants of Fetal Alcohol Syndrome

CONCLUSIONS: Thus, we find that a major effect of chronic intermittent alcohol on the developing cerebral cortex is an overall imbalance in regionalization, with enrichment of gene expression related to the production of posterodorsal progenitors and a diminution of anteroventral progenitors, a finding which parallels behavioral and morphological phenotypes observed in animal models of high-dose prenatal alcohol exposure, as well as patients with FAS.PMID:33682149 | DOI:10.1111/acer.14590
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Source Type: research