Gut-liver axis modulation of Panax notoginseng saponins in nonalcoholic fatty liver disease

ConclusionPNS exerted hepatoprotection against NAFLD in both ob/ob and HFD-induced obese mice, primarily by mediating the gut-liver axis in a TLR4-dependent manner.Graphic abstractPanax notoginseng saponins (PNS) ameliorated hepatic steatosis and fibrosis, and gut-liver axis-mediated pathogenesis of NAFLD is proposed to occur in a TLR4-dependent manner.

http://link.springer.com/10.1007/s12072-021-10138-1

Source: Hepatology International - March 3, 2021 Category: Infectious Diseases Source Type: research