Metallothionein-1G suppresses pancreatic cancer cell stemness by limiting activin A secretion via NF- κ B inhibition

Conclusions: MT1G suppresses PDAC stemness by limiting activin A secretion via NF-κB inhibition. The blockade of the activin A signaling with follistatin may provide a promising therapeutic strategy for overcoming gemcitabine resistance in PDAC.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Kai Li, Zhicheng Zhang, Yu Mei, Qingzhu Yang, Shupei Qiao, Cheng Ni, Yao Yao, Xinyuan Li, Mengmeng Li, Dongdong Wei, Wangjun Fu, Xuefei Guo, Xuemei Huang, Huanjie Yang Tags: Research Paper Source Type: research