Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water.

In conclusion, these data point to potential differences in absorption and disposition properties of V4+ and V5+ salts and may explain the higher sensitivity in rats following drinking water exposure to V5+ than V4+ and highlights the importance of internal dose determination in toxicology studies.
PMID: 33421504 [PubMed - as supplied by publisher]

Source: Toxicology and Applied Pharmacology - January 6, 2021 Category: Toxicology Authors: Harrington JM, Haines LG, Levine KE, Liyanapatirana C, Essader AS, Fernando RA, Robinson VG, Roberts GK, Stout MD, Hooth MJ, Waidyanatha S Tags: Toxicol Appl Pharmacol Source Type: research