Increased hepatic fat content in patients with resistance to thyroid hormone beta.
CONCLUSIONS: Our findings provide evidence that impairments in intra-hepatic TRβ-signaling due to mutations of the THRB gene can lead to hepatic steatosis, which emphasizes the influence of TH in the liver metabolism of lipids and provides a rationale for the development TRβ-selective thyromimetics. Consequently, new molecules with a very high TRβ affinity and hepatic selectivity have been developed for the treatment of lipid-associated hepatic disorders, particularly non-alcoholic fatty liver disease.
PMID: 33353459 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
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