Lyme Disease in Humans.

Lyme Disease in Humans. Curr Issues Mol Biol. 2020 Dec 11;42:333-384 Authors: Radolf- JD, Strle K, Lemieux JE, Strle F Abstract Lyme disease (Lyme borreliosis) is a tick-borne, zoonosis of adults and children caused by genospecies of the Borrelia burgdorferi sensu lato complex. The ailment, widespread throughout the Northern Hemisphere, continues to increase globally due to multiple environmental factors, coupled with increased incursion of humans into habitats that harbor the spirochete. B. burgdorferi sensu lato is transmitted by ticks from the Ixodes ricinus complex. In North America, B. burgdorferi causes nearly all infections; in Europe, B. afzelii and B. garinii are most associated with human disease. The spirochete's unusual fragmented genome encodes a plethora of differentially expressed outer surface lipoproteins that play a seminal role in the bacterium's ability to sustain itself within its enzootic cycle and cause disease when transmitted to its incidental human host. Tissue damage and symptomatology (i.e., clinical manifestations) result from the inflammatory response elicited by the bacterium and its constituents. The deposition of spirochetes into human dermal tissue generates a local inflammatory response that manifests as erythema migrans (EM), the hallmark skin lesion. If treated appropriately and early, the prognosis is excellent. However, in untreated patients, the disease may present with a wide range of clinical manifestations, most...
Source: Current Issues in Molecular Biology - Category: Molecular Biology Authors: Tags: Curr Issues Mol Biol Source Type: research

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J. Mater. Chem. A, 2021, Accepted Manuscript DOI: 10.1039/D1TA03936A, PaperYueyan Zhang, Kun Zhou, Huaiyu Jiang, Sikun Zhang, Bingjie Zhang, Mengying Guo, Gang He Multi-functional copolymers based on NIPAM and thienoviologens with different number of thiophene units (n= 1, 2 and 3) were synthesized and their absorption/emission properties were systematically studied. The thienoviologens exhibited... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Ticks are obligate hematophagous ectoparasites. They are important vectors for many pathogens, of both medical and veterinary importance. Antibiotic residues in animal food are known, but very little is known about the effects of antibiotic residues in animals on the microbiome diversity of ticks and tick-borne pathogen transmission. We used a Haemaphysalis longicornis–infested mouse model to evaluate the effect of antibiotic usage on tick microbiome. Nymphal ticks were fed on an antibiotic cocktail-treated or water control mice. Adult ticks molted from nymphs fed on the antibiotic cocktail-treated mouse had a dysbio...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Conditions:   Widespread Body Pain;   Fibromyalgia Interventions:   Other: Electromyographic measurement:;   Other: Ultrasonographic measurement: Sponsor:   Kutahya Health Sciences University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Am J Trop Med Hyg. 2021 Aug 2:tpmd210183. doi: 10.4269/ajtmh.21-0183. Online ahead of print.ABSTRACTSevere fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV) is an emerging tick-borne infectious disease. Few studies have assessed the clinical usefulness of nested reverse-transcription polymerase chain reaction (RT-PCR) for diagnosing SFTS. We performed conventional RT-PCR targeting the M segment, nested RT-PCR targeting M and S segments, and real-time RT-PCR targeting the S segment of SFTSV for four patients with suspected SFTS. Although conventional RT-PCR results for the first two patients were neg...
Source: Am J Trop Med Hyg - Category: Infectious Diseases Authors: Source Type: research
The purpose of this study was to determine if observational therapy is noninferior to antibiotics for acute uncomplicated diverticulitis according to clinically relevant margins.
Source: Surgery - Category: Surgery Authors: Source Type: research
SummaryIn January 2019, a  30-year-old woman admitted to our inpatient department presented with undulating fever, pain in several joints, and significantly elevated liver enzymes and lactate dehydrogenase. After extended examination, infection withBrucella melitensis with liver, musculoskeletal, and pulmonary involvement was diagnosed and treated. Diagnosis was based on clinical examination, laboratory findings including seroconversion as a  proof of immune response, magnetic resonance imaging, three-phase bone scintigraphy, and F‑18 FDG-PET (F-18 Flourdeoxyglucose positron emission tomography) illustrating th...
Source: Wiener Medizinische Wochenschrift - Category: General Medicine Source Type: research
Dr. Auwaerter has consulted for DiaSorin, Adaptive Biotherapeutics and Pfizer; has done research sponsored by MicroB-Plex; has been an expert witness in malpractice cases involving Lyme disease; and is an unpaid board member of the American Lyme Disease Foundation. Dr. Kobayashi has no disclosures. Dr. Wormser reports receiving research grants from the Institute for Systems Biology and Pfizer, Inc. He has been an expert witness in malpractice cases involving Lyme disease; and is an unpaid board member of the non-profit American Lyme Disease Foundation.
Source: The American Journal of Medicine - Category: General Medicine Authors: Source Type: research
CONCLUSIONS: These results suggest that the early use of probiotics may have a potential ability to remodel the gut microbiota during recovery from antibiotic treatment. However, further study is required to fully understand the long-term effects including the clinical benefits.PMID:34331676 | DOI:10.1007/s12519-021-00443-y
Source: World Journal of Pediatrics : WJP - Category: Pediatrics Authors: Source Type: research
AbstractSummaryConsidering the lack of studies determining the real TPTD efficacy in individuals who develop MRONJ, our objective was to combine the available data on MRONJ cases treated with TPTD. The findings demonstrated that TPTD in combination with another therapy, especially antibiotic therapy, can be considered an effective protocol for MRONJ.PurposeTo integrate the data published on the effect of teriparatide (TPTD) therapy on cases of medication-related osteonecrosis of the jaws (MRONJ) into a comprehensive analysis of clinical features.MethodsAn electronic search was undertaken in six databases. Descriptive analy...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Growing up a musically-obsessed child in the 80's, Daryl Hall was one of my biggest inspirations. A masterful, inventive songwriter with an ocean of soul, he set me on the path to being an artist, to never waste a word, and to sing because I mean it. With six number ones and five additional top ten hits throughout the 70's and 80's Daryl Hall and John Oates are the number one duo in music history. Still at the top of his game at 69 years old, Daryl has won legions of new fans with his hit MTV Live show Live From Daryl's House. In February of 2015, at my very sickest from chronic Lyme and Bartonella, after it was missed b...
Source: Science - The Huffington Post - Category: Science Source Type: news
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