Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression

Metabolomic studies suggest plasma levels of bile acids (BAs) are elevated amongst subjects with non-alcoholic fatty liver disease (NAFLD) compared to healthy controls. However, it remains unclear whether or not specific BAs are associated with the clinically relevant transition from nonalcoholic fatty liver (i.e. simple steatosis) to non-alcoholic steatohepatitis (NASH), or enhanced progression of hepatic fibrosis, or genetic determinants of NAFLD/NASH.

Source: Metabolism - Clinical and Experimental - December 1, 2020 Category: Biomedical Science Authors: Nisreen Nimer, Ibrahim Choucair, Zeneng Wang, Ina Nemet, Lin Li, Janet Gukasyan, Taylor L. Weeks, Naim Alkhouri, Nizar Zein, W.H. Wilson Tang, Michael A. Fischbach, J. Mark Brown, Hooman Allayee, Srinivasan Dasarathy, Valentin Gogonea, Stanley L. Hazen Source Type: research